COSTIS Installation COmpact Solid Target Irradiation System - - PowerPoint PPT Presentation

COSTIS Installation

• COmpact Solid Target

Irradiation System (COSTIS) delivered with flange for IBA 18/9 installation

• Custom flange designed /

fabricated for PETtrace installation at IBA-MI site at Virginia Commonwealth University, Richmond, VA

IBA

Target Control System

• Programmable Logic

Controller (PLC) with touchscreen buttons and target status display

• Automates loading and

unloading of target disk

• Provides controls for

remote closure of target disk pig IBA

Target Control Terminal Box

• Cable penetration into

vault/shield required

• Distributes control

signals to target pneumatic cylinders, air dry valve, and solenoid cooling system valves IBA

Cooling System

• TeO2 exhibits low

thermal conductivity (~30 mW/K-cm)

• Vapor pressure is

significant prior to melting

• Target oxide cooling

becomes paramount

• Water cooling for both

target disk and graphite collimator

• Helium cooling for

disk cavity w/venting prior to unloading

• Cooling drain/air

drying for disk IBA

Solid Target Preparation

• Platinum disk 24mm diameter w/ circular

12mm cavity—high thermal conductivity

• Isotopically enriched TeO2 melted into

cavity

• Typically 200 mg w/5% Al2O3
• Annealed to convert TeO3 to TeO2

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Irradiation Parameters

• Optimal energy range 9-13 MeV
• Higher energies (~15 MeV) require thick

target (~1 mm) to fully stop beam (SRIM2000 transport code)

• Nominal power dissipated by target ~300W

given sufficient cooling reserves and necessary beam quality

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Optimizing Production Yield

Typical Production Yields

• 124Te enrichment

extremely high

• Thick target
• Cooling reserves!
• Favorable beam

profile

• Optimal energy

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Agreement with predicted 0.54 mCi (20 MBq)/uA-h

Target Degradation

• Chemical—volatile organic compounds

break down oxide matrix to elemental Te

• Corrosion—disk alloy; de-ionized cooling
• Mechanical—scratch results in He leak
• Irradiation—194Au (39.5h), 196 Au (6.18d)

from Pt isotopes

• Thermal—reannealing during bombardment
• r migration of matrix during recovery

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Radioiodine Recovery

• Thermochromatographic separation

associated with high yields

• Diffusion/transport/trapping regimes
• ptimized
• Quartz tube furnace did not disappoint!
• Nominally 90-95% trapping yield using

0.02M NaOH

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Radionuclidic Purity

• HPGe gamma spectrometry per ANSI

N42.14, calibrated with 152Eu standard

• 18F and 123I impurities minimized at EOS
• 125I, 126I, 130I, 131I below detection limit of

0.1%

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Quality Control

• Radiochemical purity

by HPLC to determine

• xidation species
• Chemical purity by

UV spectrophotometry for Te

• pH
• LAL
• Sterility
• Visible impurities

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Next Steps

• COSTIS proved reliable and well

engineered for commercial 124I production

• Adaptable to any internal beam cyclotron in

the IBA fleet

• 124I production ramping up
• 64Cu, 76Br targets in pipeline

IBA