COSTIS Installation COmpact Solid Target Irradiation System - - PowerPoint PPT Presentation

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COSTIS Installation COmpact Solid Target Irradiation System - - PowerPoint PPT Presentation

IBA COSTIS Installation COmpact Solid Target Irradiation System (COSTIS) delivered with flange for IBA 18/9 installation Custom flange designed / fabricated for PETtrace installation at IBA-MI site at Virginia Commonwealth


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SLIDE 1

COSTIS Installation

  • COmpact Solid Target

Irradiation System (COSTIS) delivered with flange for IBA 18/9 installation

  • Custom flange designed /

fabricated for PETtrace installation at IBA-MI site at Virginia Commonwealth University, Richmond, VA

IBA

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SLIDE 2

Target Control System

  • Programmable Logic

Controller (PLC) with touchscreen buttons and target status display

  • Automates loading and

unloading of target disk

  • Provides controls for

remote closure of target disk pig IBA

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SLIDE 3

Target Control Terminal Box

  • Cable penetration into

vault/shield required

  • Distributes control

signals to target pneumatic cylinders, air dry valve, and solenoid cooling system valves IBA

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SLIDE 4

Cooling System

  • TeO2 exhibits low

thermal conductivity (~30 mW/K-cm)

  • Vapor pressure is

significant prior to melting

  • Target oxide cooling

becomes paramount

  • Water cooling for both

target disk and graphite collimator

  • Helium cooling for

disk cavity w/venting prior to unloading

  • Cooling drain/air

drying for disk IBA

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SLIDE 5

Solid Target Preparation

  • Platinum disk 24mm diameter w/ circular

12mm cavity—high thermal conductivity

  • Isotopically enriched TeO2 melted into

cavity

  • Typically 200 mg w/5% Al2O3
  • Annealed to convert TeO3 to TeO2

IBA

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SLIDE 6

Irradiation Parameters

  • Optimal energy range 9-13 MeV
  • Higher energies (~15 MeV) require thick

target (~1 mm) to fully stop beam (SRIM2000 transport code)

  • Nominal power dissipated by target ~300W

given sufficient cooling reserves and necessary beam quality

IBA

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SLIDE 7

Optimizing Production Yield

Typical Production Yields

10 20 30 40 50 60 70 80 90 100 50 100 150 200 250 uA-h mCi
  • 124Te enrichment

extremely high

  • Thick target
  • Cooling reserves!
  • Favorable beam

profile

  • Optimal energy

IBA

Agreement with predicted 0.54 mCi (20 MBq)/uA-h

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SLIDE 8

Target Degradation

  • Chemical—volatile organic compounds

break down oxide matrix to elemental Te

  • Corrosion—disk alloy; de-ionized cooling
  • Mechanical—scratch results in He leak
  • Irradiation—194Au (39.5h), 196 Au (6.18d)

from Pt isotopes

  • Thermal—reannealing during bombardment
  • r migration of matrix during recovery

IBA

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SLIDE 9

Radioiodine Recovery

  • Thermochromatographic separation

associated with high yields

  • Diffusion/transport/trapping regimes
  • ptimized
  • Quartz tube furnace did not disappoint!
  • Nominally 90-95% trapping yield using

0.02M NaOH

IBA

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SLIDE 10

Radionuclidic Purity

  • HPGe gamma spectrometry per ANSI

N42.14, calibrated with 152Eu standard

  • 18F and 123I impurities minimized at EOS
  • 125I, 126I, 130I, 131I below detection limit of

0.1%

IBA

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SLIDE 11

Quality Control

  • Radiochemical purity

by HPLC to determine

  • xidation species
  • Chemical purity by

UV spectrophotometry for Te

  • pH
  • LAL
  • Sterility
  • Visible impurities

IBA

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SLIDE 12

Next Steps

  • COSTIS proved reliable and well

engineered for commercial 124I production

  • Adaptable to any internal beam cyclotron in

the IBA fleet

  • 124I production ramping up
  • 64Cu, 76Br targets in pipeline

IBA