CEPir Cell Enrichment Process for Isolation of Rare Cells w - - PowerPoint PPT Presentation

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CEPir Cell Enrichment Process for Isolation of Rare Cells w - - PowerPoint PPT Presentation

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CEPir Cell Enrichment Process for Isolation of Rare Cells w w w . t o p b i o x . c o m s a l e s @ t o p b i o x . c o m BioCEPs Vision Lead the next generation of

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SLIDE 1

CEPir

Cell Enrichment Process for Isolation of Rare Cells

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SLIDE 2

BioCEP’s Vision

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Lead the next generation of cell isolation devices which enable novel therapeutics and diagnostics by offering an advanced rare cell isolation technology which can be integrated with front and downstream technologies

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SLIDE 3

The CEPir – Cell Enrichment Process for Isolation of Rare Cells

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CEPir is a research use only device and may not be used for commercial applications

The CEPir is designed to overcome:

 Cells aggregates  Membranes abrasions  Cell clusters  Harmful aridity and plunging  Limited magnetic fields

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SLIDE 4

The Cell Enrichment Process

A Novel Design for Effective Isolation

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BioCEP’s patent protects the unique design which creates a closed magnetic field in which target cells are held in stasis, while non-target cells flow out of the system.

BioCEP’s CEPir

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SLIDE 5

Unique Design

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  • 4 Isolation Areas for rare cell isolation
  • High Recovery
  • Positive Isolations and Depletion

Closed Magnetic Field

  • High Purity
  • High Viability
  • No Cell Abrasion or Clusters

Target Cells Held in Stasis

  • Short Separation Time
  • Allows Separation in Dialysis Method
  • Gentle On the Cells

Flow Through

  • Scenario Creation
  • Controlled Field Intensities, Concentrations and

Volumes Flexible Software

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SLIDE 6

CEPir Electromagnets

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 Specimen flows through 4 separation areas

 Cell held in stasis  Controlled fields intensities Isolated Cells Held in Stasis within Buffer Fluid  Variety of reagents and beads  Up to 109 tagged cells  Gradient

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SLIDE 7

CEPir Flow Through Technology

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 Gentle passage  Quick Isolations  High volumes  Option to work in batches  Dialysis option 3 peristaltic pumps control the flow

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SLIDE 8

Flexible Software

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Touchscreen Editor PC Editor  Parameter control  Simple customization

  • f loaded

scenarios  Endless scenario creations  Off-screen editing ease

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SLIDE 9

Cell Friendly Environment

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Gentle flow through Buffer prevents aridity Contact free - cells held in stasis Gentle degaussing Plunge free cell capture

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SLIDE 10

Viability ! Purity ! Recovery !

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Cell Viability (%) Purity (%) Contam-ination (%)

  • vs. Competitor (%)

CD 4 99.5 98.2 7.9 15 6 CD 8 99 95.5 2.7 6 6 CD 19 98.9 86.5 1.1 33 18 CD 15 99 91.2 3.9 10 19 CD 14 99.1 93.5 2.2 16 8

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SLIDE 11

The CEPir Advantage

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 0.5-50 ml per batch

up to 109th tagged cells

 Software controlled  Fits under a hood for sterile

isolations

 High recovery, purity, viability  Rare cell isolation (1 in 109th cells)  No cell abrasions, aggregates  Flow through, short process

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SLIDE 12

Technical Spec

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56 cm 55 cm

Fits under a hood for sterile isolations

 Power: AC100v-240v 600w  Operating Temp: 5-40℃  Operating Humidity: 0-85%  Environmental: RoHS Compliant  Safety: EN60950-1/2006  EMI: EN55022/2006 Class A  Interface: USB, TCP/IP, RS-232, WiFi

22 in 21.7 in

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SLIDE 13

Simple Kit Installation

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SLIDE 14

For More Information on the CEPir www.biocep.com

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