Burden and trend of Cancer in Europe: First step towards Earlier - - PowerPoint PPT Presentation

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Burden and trend of Cancer in Europe: First step towards Earlier - - PowerPoint PPT Presentation

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Burden and trend of Cancer in Europe: First step towards Earlier Detection Isabelle Soerjomataram Budapest 20 May 2019 Early Detection: Recommendation Early Detection: Recommendation Burden of Cancer in Europe Cancer incidence: European

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Burden and trend of Cancer in Europe: First step towards Earlier Detection

Isabelle Soerjomataram

Budapest – 20 May 2019

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Early Detection: Recommendation

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Early Detection: Recommendation

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Burden of Cancer in Europe

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Cancer incidence: European Regions

Source: GLOBOCAN 2018

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Source: GLOBOCAN 2018

Cancer mortality: European Regions

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Melanoma of the Skin

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Incidence & Mortality Melanoma

Source: GLOBOCAN 2018

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Melanoma of skin

Source: ECIS

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Incidence of Melanoma

Source: GLOBOCAN 2018

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Mortality of Melanoma

Source: GLOBOCAN 2018

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Incidence & Mortality Melanoma, E

Source: GLOBOCAN 2018

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Trend incidence of Melanoma

Source: CI5plus

* regional registries

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Trend mortality of Melanoma

Source: WHO mortality

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Incidence & Mortality – by age

Source: CI5plus, WHO mortality

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Success in Prevention of Melanoma

  • SunSmart since 1980
  • Secular changes
  • ‘Population dilution’

Mortality reduction

  • Better treatment

and follow-up

  • Early detection
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Oral Cavity Cancer

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Source: GLOBOCAN 2018

Incidence & Mortality from oral cavity cancer, world

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Incidence of Oral Cavity cancer

Source: GLOBOCAN 2018, incl. lip

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Mortality of Oral Cavity cancer

Source: GLOBOCAN 2018, incl. lip

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Source: GLOBOCAN 2018, incl lip

Incidence & Mortality from oral cavity cancer

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Survival from Oral cavity Cancer

Source: ECIS

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Lip, oral cavity and pharynx

Source: CI5plus

* regional registries

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Lip, oral cavity

Source: WHO mortality

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Prevention - Oral Cavity

  • Separate w Lip Cancer!
  • Primary prevention
  • Screening – visual & physical

examination for Oral Potential Malignant disorders

  • Early detection – GP and dentists
  • Smokers & alcohol drinkers
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Breast Cancer

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Breast cancer screening: status

Basu et al 2018

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Incidence, Mortality of Breast cancer

Source: GLOBOCAN 2018

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Survival from Breast cancer

Source: ECIS

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Incidence of Breast cancer

Source: GLOBOCAN 2018

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Mortality of Breast cancer

Source: GLOBOCAN 2018

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Incidence, mortality of Breast cancer

Source: GLOBOCAN 2018

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Trend incidence of Breast cancer

Source: CI5plus

* regional registries

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Source: WHO mortality

Trend mortality of Breast cancer

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Trend incidence – by age

Source: CI5plus, WHO mortality

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Breast Cancer Prevention

  • Primary prevention
  • Screening
  • Early detection
  • Clinical Breast Examination – sufficient

evidence for stage shift but not mortality reduction

  • Self Breast Examination – inadequate

evidence to reduce mortality even if done correctly

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Colorectal cancer

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Incidence, mortality of CRC

Source: GLOBOCAN 2018

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Incidence of Colorectum cancer

Source: GLOBOCAN 2018

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Mortality of Colorectum cancer

Source: GLOBOCAN 2018

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I & M of Colorectum cancer

Source: GLOBOCAN 2018

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Survival from Colorectum Cancer

Source: ECIS

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Trend incidence of Colorectum cancer

Source: CI5plus

* regional registries

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Source: WHO mortality

Trend mortality of Colorectum cancer

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Araghi et al 2019 Colon Cancer Rectal Cancer

Increasing rates in young adults

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Colorectal cancer screening: status

Basu et al 2018

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Colorectal Cancer Prevention

  • Primary prevention
  • Better screening (implementation &

quality control)

  • Early detection?
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Conclusion

  • Great variation in Europe
  • Examples based on best practice
  • Early detection
  • Determine burden
  • Scope for early detection
  • Implementation
  • Quality assurance
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Acknowledgement

  • Cancer registries – Cancer incidence
  • Jerome Vignat
  • Organisors
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Prostate cancer

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Prostate Cancer Incidence

Source: GLOBOCAN 2018

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Prostate cancer mortality

Source: GLOBOCAN 2018

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Incidence, mortality - global

Source: GLOBOCAN 2018

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Incidence, mortality – Europe

Source: GLOBOCAN 2018

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Trend incidence: Prostate cancer

Source: CI5plus

* regional registries

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Trend Mortality: Prostate cancer

Source: WHO mortality

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Prostate cancer trend – by age

Source: CI5plus, WHO mortality

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Survival from Prostate cancer

Source: ECIS