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Are synapses binary or analog? -Yes. Tea Talk Naoki Hiratani - PowerPoint PPT Presentation

Apr 24, 2023 •284 likes •350 views

Are synapses binary or analog? -Yes. Tea Talk Naoki Hiratani 2020-01-29 Reference: Dorkenwald, Seung et al., Binary and analog variation of synapses between cortical pyramidal neurons. BioRxiv, 2019 Spine head volume is proportional to the

  1. Are synapses binary or analog? -Yes. Tea Talk Naoki Hiratani 2020-01-29 Reference: Dorkenwald, Seung et al., Binary and analog variation of synapses between cortical pyramidal neurons. BioRxiv, 2019

  2. Spine head volume is proportional to the “synaptic weight” (Matsuzaki et al., 2001) Spine head volume seemingly follows unimodal log-normal distribution (Bartol et al., 2017) Is there the second peak here?

  3. Precise measurement of the spine head volume distribution by EM reconstruction Spine head volume is better fitted by a bimodal distribution

  4. Spines belongs to a multi-synaptic connection are more likely to be in the up state Up state fraction Sister synapses (multi-synaptically connected synapses) have correlated binary component

  5. Summary • Spine head volume is given by the binary + analog components • Binary components are correlated among sister synapses Caveats • Reconstruction is limited to a small volume (~100 um) • No longer true if other type of synapses are included (analysis is limited to Pyr-Pyr connections in L2/3 of V1)

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