Are synapses binary or analog? -Yes. Tea Talk Naoki Hiratani - - PowerPoint PPT Presentation

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Apr 24, 2023 284 likes •352 views

Are synapses binary or analog? -Yes. Tea Talk Naoki Hiratani 2020-01-29 Reference: Dorkenwald, Seung et al., Binary and analog variation of synapses between cortical pyramidal neurons. BioRxiv, 2019 Spine head volume is proportional to the

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Are synapses binary or analog?

Yes.

Tea Talk Naoki Hiratani 2020-01-29

Reference: Dorkenwald, Seung et al., Binary and analog variation of synapses between cortical pyramidal neurons. BioRxiv, 2019

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Spine head volume seemingly follows unimodal log-normal distribution Spine head volume is proportional to the “synaptic weight”

(Bartol et al., 2017)

Is there the second peak here?

(Matsuzaki et al., 2001)

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Spine head volume is better fitted by a bimodal distribution Precise measurement of the spine head volume distribution by EM reconstruction

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Spines belongs to a multi-synaptic connection are more likely to be in the up state Sister synapses (multi-synaptically connected synapses) have correlated binary component

Up state fraction

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Caveats

Reconstruction is limited to a small volume (~100 um)
No longer true if other type of synapses are included

(analysis is limited to Pyr-Pyr connections in L2/3 of V1) Summary

Spine head volume is given by the binary + analog components
Binary components are correlated among sister synapses