Visualizing Model Architecture john.sekar@mssm.edu SASB `17 - - PowerPoint PPT Presentation

Visualizing Model Architecture

john.sekar@mssm.edu

SASB `17

Kinetics ~ Reaction Rules

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BioNetGen Kappa Simmune SBML-multi

Causality Analysis

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Story Influence Diagram

RINF of FceRI model with 24 rules

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Goals

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Structure Graph Representation

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Correspondence Map

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Procedure

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Rule consumes a pattern

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Rule produces a pattern

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Rule requires a pattern

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Atom-Rule Graph

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AR of FceRI model with 24 rules

Compression Pipeline

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18 System-specific complexity Universal principles Atom-Rule Graph Prioritization Grouping Structures Grouping Rules Compression

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Full AR Graph

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Prioritized Nodes

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Grouping Structures

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Grouping Rules

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Compression

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Larger Model

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Relative Compactness

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Future Tools

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Future Tools

Summary

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Ac Acknow

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ledgements ents Ref efer erences ences

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