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University Entrepreneurship & Regional Economic Development David B. Audretsch The Traditional University The Humboldt Model (Wilhelm von Humboldt, 1767-1835) Freedom & independence of research & teaching knowledge


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University Entrepreneurship & Regional Economic Development

David B. Audretsch

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The Traditional University

  • The Humboldt Model

(Wilhelm von Humboldt, 1767-1835)

  • Freedom & independence of research &

teaching

  • “knowledge for its own sake”
  • Little valuation for engagement & societal impact
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Role of University in the Solow Economy

  • Limited contribution for investment in physical

capital

  • Limited link to (exogenous) knowledge
  • Contribution in terms of social and political

values

  • Limited contribution to economic development
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Role of University in the Romer Economy

  • Competitiveness Crisis of 1970s
  • Comparative advantages shifts from physical

capital of knowledge

  • University is source of knowledge
  • University financial shortfall
  • Demand oriented
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The Knowledge Filter

“A wealth of scientific talent at American colleges and

universities – talent responsible for the development of numerous innovative scientific breakthroughs each year – is going to waste as a result of bureaucratic red tape and illogical government regulations…What sense does it make to spend billions of dollars each year on government-supported research and then prevent new developments from benefiting the American people because of dumb bureaucratic red tape?”

U.S. Senator Birch Bayh, 1980

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The Bayh-Dole Act of 1980

  • Penetrate the Knowledge Filter
  • Creation of the Technology Transfer Office (TTO)
  • Most studies analyzing commercialization of

university research limited to measures of what the TTO does

  • Intellectual property disclosed to and registered

by TTO may lead to systematic underestimation

  • f commercialization and innovation emantating

from university research (Thursby & Thursby, 2005; Shane, 2004)

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SLIDE 7

Emergence of Entrepreneurial University

  • Facilitate knowledge spillovers from university
  • University as solution provider – user oriented

fields and programs (i.e. biochemistry, informatics)

  • Demand orientation rather than “knowledge for

its own sake”

  • Provision of conduits for knowledge spillovers –

technology transfer offices, incubators, science parks, sponsored research

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SLIDE 8

En trepren eu rial Un iversity

X X X X

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University Patents as a Share of All Patents with Domestic Assignees

0.005 0.01 0.015 0.02 0.025 0.03 0.035 0.04 1948 1950 1952 1954 1956 1958 1960 1962 1964 1966 1968 1970 1972 1974 1976 1978 1980 1982 1984 1986 1988 1990 1992 1994 1996

University Patent Issue Year (Mowery 2005)

Share %

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Distribution of University Patents

500 1 000 1 500 2 000 2 500 3 000 3 500 4 000 4 500 5 000 University of California University of Texas University of Wisconsin Cornell University Harvard University State University of New York Michigan State University Duke University University of Maryland System University of Southern California University of Utah Iowa State University Yale University University of Massachusetts University of Kentucky Emory University University of Arkansas University of Nebraska Thomas Jefferson University University of Connecticut University of Tennessee University of Missouri Brown University University of Oklahoma Rensselaer Polytechnic Institute University of Medicine and Dentistry… University of Cincinnati Auburn University Washington State University University of Hawaii Colorado State University University of Houston New Jersey Institute of Technology Tulane University

Number of patents issued from 1998 to 2008

Number of patents

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Disappointing Assessment of Technology Transfer

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Paucity of University Entrepreneurship?

  • AUTM reports annual mean of 426 startups from

U.S. Universities

  • MIT TTO reported 29 startups
  • Stanford TTO reported 6 startups
  • Based on AUTM data, one startup generated per

$368 million of R&D

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Has University Entrepreneurship been Underestimated?

  • Most studies analyzing commercialization of

university research limited to measures of what the TTO does

  • Intellectual property disclosed to and registered

by TTO may lead to systematic underestimation

  • f commercialization and innovation emantating

from university research (Thursby & Thursby, 2002, “Who Is Selling the Ivory Tower?” Management Science; Shane, 2004, “Technological Opportunities and New Firm Creation,” Management Science)

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Technology Transfer Office Mission Statements

Primary objectives of the UTTO Percentage of times appeared in mission statement (%) Licensing for royalties 78.72 IP protection/management 75.18 Facilitate disclosure process 71.63 Sponsored research and assisting inventors 56.74 Public good (disseminate information/technology 54.61 Industry relationships 42.55 Economic development (region, state) 26.95 Entrepreneurship and new venture creation 20.57 N = 128 TTOs.

Source: G. Markman, P. Phan, D. Balkin & P. Gianiodis, “Entrepreneurship and University-Based Technology Transfer, “ Journal of Business Venturing, 2005

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“Making the switch from science to business” Nature

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Asking What Scientists Do Not What the University Does

  • 16,693 scientists awarded National Cancer

Institute (NCI) grant, 1998-2002 (top 20%)

  • $5,350 million NCI grant awards
  • NCI awards matched to patents
  • 398 distinct patentees, (1,204 patents), 1998-

2004

  • 1 in 4 scientists started new business

Aldridge & Audretsch, “The Bayh-Dole Act and Scientist Entrepreneurship”, Research Policy, 2011.

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Scientist Entrepreneurship

  • Measurement of scientist entrepreneurship by

AUTM & university TTO’s may underestimate extent of scientist entrepreneurship

  • Based on AUTM data, one startup generated per

$368 million of R&D

  • Aldridge & Audretsch (Research Policy, 2011)

implies one startup generated per $12 million of R&D

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Limitations of Previous Research

  • n Scientist Entrepreneurship
  • Limited to a single field of science – cancer research
  • Limited to the highest performing scientists
  • Unanswered questions

– “To what extent is the high rate of entrepreneurial activity exhibited by the high performing cancer research scientists prevalent across different types of scientific fields for different types of scientists?”

  • - “To what extent do the main determinants of scientist

entrepreneurship hold across different scientific fields & heterogeneous types of scientists?

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“Scientist Entrepreneurship: Does the Scientific Field Make a Difference?” Taylor Aldridge, David B. Audretsch &Venkata Nadella

  • Ask What Scientists Do & Not What the TTO

Does to Commercialize Research

  • Move Beyond Traditional Individual-Specific

Characteristics in Explaining Propensity for Scientist to Engage in Entrepreneurship

  • Move Beyond University Characteristics in

Explaining Scientist Commercialization

  • Why & How Do Scientists Become

Entrepreneurs?

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Creating a Scientist Entrepreneurship Database

  • Web of knowledge database contained email addresses of

9361 scientists that received NSF funding between 2005 and 2012-Q2.

  • Online survey questionnaire directed to the entire population
  • f 9361 scientists in the first round of survey administration
  • 30 scientists were on sabbatical, 9 scientists were inactive, and

email addresses of 172 scientists were returned since they were incorrect/incomplete.

  • Survey sample of 9150 scientists (97.75 percent of the

population

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Creating a Scientist Entrepreneurship Database

  • Scientists spanned 6 different fields of

research,

  • 1899 scientist responses (response

rate of 20.75%) from three rounds of administering questionnaire

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Hypothesis 1: Age is positively related to the propensity for scientists to become an entrepreneur

  • For general entrepreneurship literature, age has negative

impact on entrepreneurship (Parker, 2010, The Economics of Entrepreneurship, Oxford University Press; Reynolds, Carter, Gartner & Greene (2004) “The Prevalence of Nascent Entrepreneurs in the United States: Evidence from the Panel Study of Entrepreneurial Dynamics,” Small Business Economics)

  • Levin and Stephan, (1991), “Research Productivity Over the

Life Cycle; Evidence for Academic Scientists,” American Economic Review; Stephan, Paula., & Levin, Sharon (1992), Striking the Mother Lode in Science: the Importance of Age, Place, and Time, Oxford University Press

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Hypothesis 2: Female scientists less likely to be an entrepreneur

  • Studies from general population find likelihood
  • f female entrepreneurship lower than male

entrepreneurship (Minniti & Nardone (2007) “Being in Someone Else’s Shoes: The Role of Gender in Nascent Entrepreneurship,” Small Business Economics)

  • Aldridge & Audretsch (2011) find no difference

for gender for cancer scientists

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Hypothesis 3: The propensity for a scientist to become an entrepreneur is positively related to human capital

  • Positive relationship found between human

capital and entrepreneurship for general population (Davidsson & Honig (2003) “The role

  • f Social and Human Capital among Nascent

Entrepreneurs,” Journal of Business Venturing)

  • Aldridge & Audretsch (2011) find human capital

to have no impact on scientist entrepreneurship for cancer researchers

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Hypothesis 4: Social capital is positively related to the propensity for a scientist to become an entrepreneur

  • Positive relationship found between social capital and

entrepreneurship for general population (Aldrich & Martinez (2010), “Entrepreneurship as Social Construction,” in Handbook of Entrepreneurship)

  • Mosey & Wright, Michael (2007) “From Human Capital to

Social Capital: A Longitudinal Study of Technology Based Academic Entrepreneurs,” Entrepreneurship Theory and Practice and Aldridge & Audretsch (2011) find social capital to be most important determinant of scientist entrepreneurship for cancer researchers

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Hypothesis 5: Scientist entrepreneurship is positively related to the resources available to the technology transfer office

  • Clarysse, Wright, Lockett, Van de Velde, &

Vohora (2005) “Spinning Out New Ventures: A Typology of Incubation Strategies from European Research Institutions,” Journal of Business Venturing

  • Di Gregorio & Shane (2003), “Why Some

Universities Generate More TLO Start-Ups than Others?”, Research Policy

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Hypothesis 6 Access to financial resources is positively related to scientist entrepreneurship

  • For general population, access to financial

resources found to have positive impact on entrepreneurship (Gompers &Lerner (2010), “Equity Financing,” in Handbook of Entrepreneurship Research)

  • Access to financial resources positively

influences entrepreneurship for high-tech & knowledge industries (Kerr & Nanda (2009) “Financing Constraints and Entrepreneurship,” National Bureau of Economic Research Working Paper

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SLIDE 28

Creating a Scientist Entrepreneurship Database

  • Web of knowledge database contained email addresses
  • f 9361 scientists that received NSF funding between

2005 and 2012-Q2.

  • Online survey questionnaire directed to the entire

population of 9361 scientists in the first round of survey administration

  • 30 scientists were on sabbatical, 9 scientists were

inactive, and email addresses of 172 scientists were returned since they were incorrect/incomplete.

  • Survey sample of 9150 scientists (97.75 percent of the

population

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SLIDE 29

Creating a Scientist Entrepreneurship Database

  • Scientists spanned 6 different fields of

research,

  • 1899 scientist responses (response rate of

20.75%) from three rounds of administering questionnaire

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12,8% 20,1% 4,6% 23,8% 9,2% 6,2% 8,2% 0% 5% 10% 15% 20% 25% 30% All Fields of Research Civil, Mechanical, and Manufacturing Innovation Environmental Biology Computer and Network Systems Physical Oceanography Particle and Nuclear Astrophysics Biological Infrastructure

Percent Scientist Startups

Scientist Startups by Field of Research

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43,8 43,0 45,1 42,5 46,0 47,3 44,4 40 41 42 43 44 45 46 47 48 49 50 All Fields of Research Civil, Mechanical, and Manufacturing Innovation Environmental Biology Computer and Network Systems Physical Oceanography Particle and Nuclear Astrophysics Biological Infrastructure

Age of Scientists who Started Up

Scientist Age and Startup Commercialization

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SLIDE 32

13% 19% 5% 25% 8% 7% 9% 5% 9% 0% 7% 4% 10% 6% All Fields of Research Civil, Mechanical, and Manufacturing Innovation Environmental Biology Computer and Network Systems Physical Oceanography Particle and Nuclear Astrophysics Biological Infrastructure 0% 5% 10% 15% 20% 25% 30%

Percent Startups by Gender

Scientist Startups and Gender

Male Scientists Female Scientists

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Scientist Characteristics, Years in Tenured Status Total Sample Started Up Non- Tenured Scientists 156 17 10.9% Tenure Scientists 0-5 Years 67 6 9.0% 6-10 Years 200 31 15.5% 11-15 Years 184 20 10.9% 16-20 Years 170 33 19.4% 21-25 Years 101 13 12.9% 26-30 Years 59 6 10.2% 31-35 42 7 16.7% More than 35 Years 32 2 6.3% Total 1011 135

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64% 62% 59% 71% 58% 75% 59% 31% 20% 39% 26% 38% 25% 32% All Fields of Research Civil, Mechanical, and Manufacturing Innovation Environmental Biology Computer and Network Systems Physical Oceanography Particle and Nuclear Astrophysics Biological Infrastructure 0% 10% 20% 30% 40% 50% 60% 70% 80%

Percent Scientists on a Board

Scientists on Board of Directors of other firms

Started Up Did Not Startup

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28,9% 9,2% 8,4% 27,6% 11,3% 23,8% 4,6% 19,7% 5,0% 4,6% 0% 5% 10% 15% 20% 25% 30% 35% Percent Scientist Startups by Region

Share of Scientist Startups by Region

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Table 8: Probit regression results estimating likelihood of scientist startups, all fields of research

Independent variables (1) (2) (3) (4)

Grant Amount (in millions) - Fin Res. 0.01 0.011 0.011 0.011 (1.85)* (2.07)** (2.04)** (2.13)** Other Funding (>750K) - Fin Res. 0.343 0.282 0.297 0.316 (2.69)*** (2.27)** (2.36)** (2.46)** # of Students - Human Res.

  • 0.001
  • 0.001
  • 0.001
  • 0.001

(-1.95)* (-1.88)* (-1.89)* (-2.03)** Years in Tenure - Human Capital

  • 0.017
  • 0.011
  • 0.01
  • 0.009

(-1.46) (-1.45) (-1.32) (-1.27) Full Professor - Human Capital

  • 0.209
  • 0.196
  • 0.201

(-1.33) (-1.23) (-1.26) Board Membership - Social Capital 0.702 0.66 0.636 0.662 (5.30)*** (5.26)*** (5.06)*** (5.19)***

  • Dept. Encourages Commercialization
  • 0.167
  • 0.161
  • 0.17
  • 0.191

(-4.14)*** (-4.07)*** (-4.24)*** (-4.47)***

  • Dept. Head Entrepreneurial Orientation

0.525 0.512 0.521 0.523 (4.02)*** (4.04)*** (4.04)*** (3.97)***

  • Univ. TTO Success

0.048 (1.15) Male 0.445 0.469 0.458 0.466 (2.33)** (2.51)** (2.43)** (2.46)** Age of Scientist 0.015 (1.2) Asia - Country of Origin

  • 0.122
  • 0.115

(-0.59) (-0.54) Midwest Region

  • 0.194
  • 0.034
  • 0.037
  • 0.026

(-1.03) (-0.19) (-0.20) (-0.14) South Region 0.048 0.054 0.05 0.057 (0.28) (0.32) (0.3) (0.33) West Region

  • 0.064
  • 0.019
  • 0.043
  • 0.027

(-0.37) (-0.11) (-0.25) (-0.16) Constant

  • 1.476
  • 0.613
  • 0.57
  • 0.753

(-2.38)** (-1.66)* (-1.53) (-1.84)* Number of Observations 758 786 777 758 Wald Chi-sq. 76.32 76.1 74.86 78.2

Notes: Absolute z values in parenthesis * Denotes significant at the 10% level; ** significant at the 5% level; *** significant at the 1% level

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Table 15: Summary of Key Determinants of Scientist Entrepreneurship by Field of Research

All Fields CMMI DEB CNS OCE PHY DBI Financial Resources + + +

  • +

Grant Amount +

  • +

Other Funding (>750K) + + + + Human Resources

  • # of Students
  • Human Capital

+

  • Years in Tenure

+

  • Full Professor
  • Social Capital

+ + + + + Board Membership + + + + + Institutional Factors + + +

  • Dept. Encourages Commercialization
  • Dept. Head Entrepreneurial Orientation

+ +

  • Univ. TTO Success

+ Scientist Demographics Male + + Asia - Country of Origin

  • Midwest Region

+ + South Region + West Region

  • Notes: CMMI is Civil, Mechanical, and Manufacturing Innovation; DEB is Environmental Biology; CNS is Computer and Network Systems; OCE is Physical Oceanography; PHY is Particle and Nuclear

Astrophysics; and DBI is Biological Infrastructure

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Conclusions

  • Scientist entrepreneurship is more prevalent and

robust than had been previously measured

  • Scientist entrepreneurship varies considerably

across scientific fields

  • Determinants of scientific entrepreneurship do

not mirror determinants for more general population

  • Determinants of scientific entrepreneurship vary

considerably across scientific fields