Trend and Challenge on Analytical Technology in Relation with Food - - PowerPoint PPT Presentation
Trend and Challenge on Analytical Technology in Relation with Food Safety PT. Angler BioChemLab Suwidji Wongso, Ph.D. March 4, 2013 Food Safety vs Food Security PT. Angler BioChemLab Food Safety: A measure of that food will not
Food Safety “ “Overlapping Aspect”
Food Security Basic Human Need : Adequate and SAFE supply of food Global Realities
Increasing Demand For Global Food Production
Today, Food must be like this . . . ?
regulation Analytical tech.
concentration mg/kg ∑ analyte in single run ~10 Analysis time hours
concentration ug/kg ∑ analyte in single run ~100 Analysis time minutes
"In recognition of the great merits of his theoretical and experimental investigations on the conduction of electricity by gases.“ 1906 Nobel Prize
1897 Early Mass Spectrometry
Joseph John Thomson
Cited from: http://masspec.scripps.edu/mshistory/
Mass spectrometry of isotopes 1922 Nobel Prize Francis William Aston Wolfgang Paul Ion Trap Technique (1913 - 1993) University of Bonn, Germany; Nobel Prize in Physics 1989 John B. Fenn ESI on Biomolecules 2002 Nobel prize Michael Karas Mechanism of MALDI & ESI University of Frankfurt, Germany MALDI Franz Hillenkamp (1936) University of Münster, Germany Fred W. McLafferty Fragmentation Mechanisms (1923) Cornell University Ithaca, New York Peptide Sequencing using MS Klaus Biemann (1926) MIT, Cambridge, Massachusetts Mechanisms and Applications
Department of Chemistry, Purdue University West Lafayette, Indiana Hans Georg Dehmelt “For the development
1989 Nobel prize Koichi Tanaka ESI on Biomolecules 2002 Nobel prize
Sensitivity ↑ Maximum Scan Speed ↑ Throughput ↑ Speed Improvement ↑
LC-‑APPI-‑MS/MS ICP-‑DRC ¡MS LC-‑ICP-‑MS LC/GC-‑Qq-‑TOF-‑HRMS GC-‑APCI-‑HR-‑Qq-‑TOF-‑MS ORBITRAP 2012 AP-‑GC ¡TOF ICP-‑ ¡MS LC-‑MS/MS GC-‑MS/MS Q ¡TRAP LC-‑NRM-‑MS APLI APPI APCI GC ¡X ¡GC-‑TOF LC-‑TOF-‑HRMS GC-‑TOF TRIPLE-‑TOF IT-‑ORBI ICP-‑MS/MS
Positive List vs
Negative List Targeted vs Non Targeted Analysis
Zero tolerance Not detected
Then…
Codex Alimentarius 0.05 mg/kg 0.05 mg/kg JP 0.1 mg/kg 0.1 mg/kg EU 0.02 mg/kg 0.05 mg/kg US 0.7 mg/kg 0.3 mg/kg ASEAN 0.1 mg/kg 0.5 mg/kg SNI 0.1 mg/kg 10 mg/kg
JP-MRL : include residues of glyphosate, glyphosate-ammonium, glyphosateisopropylamine, glyphosate-trimesium, and glyphosate sodium salts. SNI : ? EU MRL : glyphosate + trimesium US : glyphosate Codex : Soyabean and Maize : sum of glyphosate and N-acetylglyphosate, expressed as glyphosate
started by:
2006
EU 2008 0.01 South Africa 2008 0.01 Canada 2010 0.10 Malaysia 2010 0.01 Argentina 2011 0.01 New Zealand 2011 0.10
Stan Bacler, Canadian Food Inspection Agency AOAC Setting Performance Requirements, Inaugural Meeting, Rockville, MD June 25 – 26, 2008
. ¡
Japan ND (standard methods) Uniform limit (0.01ppm) MRL USA Zero tolerant MRL EU MRPL default MRL (0.01ppm) MRL
TREND REGULATION TREND REGULATION
“Biotoxins” Highly influence by geographic, natural condition (climate and wheather) and adaptation of organism
Formed from action of HCl on residual glycerides Produced naturally in foods during food manufacturing, cooking, and other processing activities such as deep frying and roasting Much of the 3-MCPD found in foods is present as 3-MCPD fatty acid esters (3-MCPD esters) and 3-MCPD esters are found in a wide range of food Forms: dichloropropanols, chloropropanediols, chloro-propanediol mono- and di- fatty acid esters, and glycidyl fatty acid esters MCPD fatty acid esters reported at high levels in refined oils (Zelinkovä et al. 2006) 3-MCPD causes infertility in rats and suppression of the immune function Genotoxic in several in-vitro assays, not genotoxic/mutagenic in-vivo (mice & rats), induced tumours in kidney, testes, mammary glands (rats)
Scientific Based
Validasi Internal Quality Control Proficiency Test Accredited
LEVEL OF QUALITY ASSURANCE ON CHEMICAL AND FOOD LABORATORY
Proficiency Test