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Thyroglossal Duct Cyst: An Unusual Presentation

Article in Ear, nose, & throat journal · August 2006

DOI: 10.1177/014556130608500720 · Source: PubMed

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PRASAD, DANNANA, PRASAD

454 ENT-Ear, Nose & Throat Journal July 2006

Thyroglossal duct cyst: An unusual presentation

ORIGINAL ARTICLE

From the Department of Otolaryngology–Head and Neck Surgery, Kas- turba Medical College, Mangalore, Karnataka State, India. Reprint requests: Dr. Kishore Chandra Prasad, Kasturba Medical College, 1st Floor, Nethravathi Bldg., Balmatta, Mangalore, Karnataka State, India 575001. Phone: 91-824-244-7394; fax: 91-824-242-8379; e-mail: kishorecprasad@yahoo.com

Kishore Chandra Prasad, MS, DLO; Naveen Kumar Dannana, MBBS, MS; Sampath Chandra Prasad, MBBS

Abstract Most thyroglossal duct cysts are located at or very close to the midline. They generally manifest as painless neck swellings, and they move on protrusion of the tongue and during deglutition. We describe a case of thyroglossal duct cyst that was unusual in that the cyst was located far from the midline, it did not move on protrusion of the tongue, and it was associated with symptoms of dysphagia and extensive neck swelling that mimicked a colloid goiter. Introduction Thyroglossal duct cysts are the most common congenital neck masses, accounting for as many as 70% of all con- genital neck anomalies.1 No gender predilection has been reported, and the age

• f

afgected patients ranges from birth to 70 years; approximately 50% of patients present before the age of 20 years.2 Some 90% of thyroglossal duct cysts lie at or very close to the midline.2 These cysts generally move during tongue protrusion and deglutition. In this article, we describe a case

• f thyroglossal duct cyst that was unusual with respect to

its location and its immobility during tongue protrusion. Case report A 42-year-old woman was referred to our outpatient clinic with a 6-month history of swelling on the right side of her neck. The size of the swelling had increased markedly over the previous month, and the patient began to experience diffjculty swallowing. She did not complain of any pain

• r other symptoms.

Clinical examination revealed that a 7 × 4-cm cystic swelling was centered in the front of the neck on the right side of the midline (fjgure 1). The swelling extended supe- riorly up to the inferior border of the hyoid bone, inferiorly up to the middle of the thyroid cartilage, and laterally up to the anterior border of the sternocleidomastoid muscle. It was mobile on swallowing but did not move with protrusion of the tongue. No cervical lymphadenopathy was present. Following the clinical examination, our dif- ferential diagnoses were colloid goiter, branchial cyst, and thyroglossal duct cyst. Findings on routine laboratory tests and thyroid func- tion studies were normal. Computed tomography (CT) of the neck demonstrated a cystic structure below the strap muscles (fjgure 2). Ultrasonography showed a unilocular cystic mass and a normal-appearing thyroid gland. A ra- dionuclide thyroid scan obtained before surgery revealed that there was no ectopic thyroid tissue within the cyst or the cyst wall. After preoperative counseling, the patient was taken for surgery under general anesthesia. An incision was made along a skin crease, and fmaps were elevated on both sides for good exposure of the surgical fjeld (fjgure 3, A). The large cyst was separate from the thyroid gland, but it adhered to the thyroid cartilage. The thyroglossal duct extended from the cyst to the hyoid bone. The cyst and the duct were excised along with the body of the hyoid bone (fjgure 3, B). The cyst measured 7.5 × 3.5 cm. A suction drain was inserted, and the wound was closed. The patient’s postoperative recovery was uneventful. According to the histopathologic analysis, the cyst was lined with pseudostratifjed ciliated columnar epithelium, predominantly and focally squamous epithelium. The subepithelium showed dense lymphocytic infjltrate. On follow-up at 18 months, the patient remained free of symptoms. Discussion The thyroid gland begins to develop during the 3rd week

• f fetal life as a median outgrowth from the fmoor of the

primitive pharynx. The normal migration of the primitive thyroid from the foramen cecum to its mature position in the anterior neck results in the creation of the thyroglossal

• duct. The lumen of the duct is usually obliterated by the

9th or 10th week of gestation.3 However, endothelial ele-

Volume 85, Number 7 455

THYROGLOSSAL DUCT CYST: AN UNUSUAL PRESENTATION

ments of the ductal lining may produce mucus, resulting in the development of a cyst. Approximately 7% of the population have thyroglossal duct remnants.4 There are four general types of thyroglossal duct based on location: thyrohyoid (60.9% of cases), suprahyoid (24.1%), supra- sternal (12.9%), and intralingual (2.1%).2 Thyroglossal duct cysts are epithelium-lined cysts that can arise at any point along the duct’s course, from the foramen cecum at the base of the tongue to the lower midline of the neck. Clinical features. Patients typically present with a pain- less midline swelling below the hyoid bone. The cysts are

• ften complicated by infection and fjstulae, but rarely by
• carcinoma. When a cyst is infected, it can enlarge rapidly

and become painful. As mentioned, 90% of thyroglossal duct cysts lie at or very close to the midline.2 Of the remainder that lie on

• ne side of the midline, 95% occur on the left.2 According

to O’Hanlon et al, most cysts that are not located in the midline are either too large to occupy a particular midline location or they represent a postoperative recurrence.5 The former explanation supports the unusual location in our patient, as her cyst was quite large. Most thyroglossal duct cysts move during swallowing and during protrusion

• f

the tongue. The degree

• f

mobility depends on the size of the cyst; the mobility of larger cysts is restricted.2 Again, the large size of the cyst in our patient probably explains why the swelling did not move during protrusion of the tongue. Moreover, we found intraopera- tively that the cyst was adherent to the thyroid cartilage; to some extent, such adhesions can also contribute to the restricted mobility of the swelling. Radiologic features. On all radiologic images, a thy- roglossal duct cyst appears as a cyst-like mass either at the level of the hyoid bone or inside the strap muscles. On ultrasonography, these cysts commonly manifest as hypoechoic areas. On CT, a thyroglossal cyst usually ap- pears as a smooth, well-circumscribed mass at any point along the course of the thyroglossal duct. Peripheral rim enhancement is usually

• bserved
• n

contrast-enhanced CT.6 CT has been recommended in the preoperative assessment

• f these large cysts to rule out laryngeal invasion.
• Management. Thyroglossal duct cysts are usually

removed because they are cosmetically undesirable or because they are associated with a previous infection. The treatment of choice for removing thyroglossal duct cysts is Sistrunk’s operation.7 Sistrunk described two basic guide- lines for successful excision of a thyroglossal duct cyst. The fjrst is to remove a central portion of the hyoid bone. The second is to not attempt to locate and remove the duct proximal to the hyoid bone; instead, remove a 5- to 10-mm core of tissue at a 45° angle to lines drawn perpendicular and horizontal to the center of the hyoid bone. According to Hawkins et al, Sistrunk’s procedure is as- sociated with recurrence rates of only 2 to 8%; when the hyoid bone is not removed, the recurrence rate is 85%.8 Hawkins et al further reported that other factors associated with an increased risk of recurrence are (1) young age, (2) involvement of the skin by the cyst, (3) lobulation of the cyst, (4) rupture of the cyst, and (5) failure to adhere to Sistrunk’s second recommendation. Recurrence is also believed to be more likely in patients with draining sinus tracts or a history of surgical excision of a previous thy- roglossal duct cyst. Pathologic characteristics. Thyroglossal duct cysts usually contain a colorless, viscous fmuid. Mucous glands may also be present. The epithelial lining of the cyst wall is variable; in most cases, a pseudostratifjed ciliated columnar

Figure 1. At presentation, the swelling is centered on the right side of neck. Figure 2. On axial CT, the cystic swelling (lower arrow) is seen under the strap muscles (top arrow).

PRASAD, DANNANA, PRASAD

456 ENT-Ear, Nose & Throat Journal July 2006

BRIGANDI, LANFRANCHI, SCHEINER, BUSCH

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Continued from page 451

lining and a squamous epithelium are present. In more than 60% of cases, ectopic thyroid tissue is present in the cyst wall.2 This tissue can give rise to carcinoma. It is estimated that carcinoma—usually the papillary type—complicates thyroglossal cysts in 1% of cases.2 Detailed histologic examination is essential not only to establish the diagnosis

• f a thyroglossal cyst, but also to exclude carcinoma. No

ectopic thyroid tissue was found in our patient. In conclusion, this case illustrates that a lateral presenta- tion of a swelling and restricted movement during tongue protrusion cannot exclude a diagnosis of thyroglossal duct cyst. References

• 1. Allard RH. The thyroglossal cyst. Head Neck Surg 1982;5:134-46.
• 2. Maran AG. Benign diseases of the neck. In: Kerr AG, ed. Scott-

Brown’s Otolaryngology. 6th ed. Vol. 5. Oxford: Butterworth- Heinemann; 1997:1-4.

• 3. Weldon BC, Krafcik, JM. Breath-holding–like spells in an infant:

An unusual presentation of lingual thyroglossal duct cyst. J Pediatr Surg 2000;35:1381-4.

• 4. Tas A, Karasalihoglu AR, Yagiz R, et al. Thyroglossal duct cyst in

hyoid bone: Unusual location. J Laryngol Otol 2003;117:656-7.

• 5. O’Hanlon DM, Walsh N, Corry J, et al. Aberrant thyroglossal cyst.

J Laryngol Otol 1994;108:1105-7.

• 6. Reede DL, Bergeron RT, Som PM. CT of thyroglossal duct cysts.

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• 7. Sistrunk WE. The surgical treatment of cysts of the thyroglossal
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• duct. Laryngoscope 1982;92:1254-8.

Figure 3. The cyst is seen intraoperatively (A) and following excision with the hyoid bone (B).

A B

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