Thinking Through The Case: Choosing a GI Therapeutic Diet Plan Liz - - PDF document

thinking through the case choosing a gi therapeutic diet
SMART_READER_LITE
LIVE PREVIEW

Thinking Through The Case: Choosing a GI Therapeutic Diet Plan Liz - - PDF document

1/11/2019 Thinking Through The Case: Choosing a GI Therapeutic Diet Plan Liz Lipski, PhD, CNS, FACN, IFMCP, BCHN, LDN Director of Academic Development/Nutrition Programs Maryland University of Integrative Health www.muih.edu Innovative


slide-1
SLIDE 1

1/11/2019 1 Thinking Through The Case: Choosing a GI Therapeutic Diet Plan

Liz Lipski, PhD, CNS, FACN, IFMCP, BCHN, LDN Director of Academic Development/Nutrition Programs Maryland University of Integrative Health www.muih.edu Innovative Healing/Mentoring Groups www.innovativehealing.com Whole Foods Diet Whole Foods Diet Gluten Free/Dairy Free Diet Gluten Free/Dairy Free Diet Specific Carbohydrate Diet Specific Carbohydrate Diet GAPS Diet GAPS Diet Anti- Candida Diet Anti- Candida Diet Elemental Diet/Poly- meric Diet Elemental Diet/Poly- meric Diet Rotation Diet Rotation Diet Low Histamine or Oxylate Low Histamine or Oxylate Restorative Diet Restorative Diet FODMAP Diet FODMAP Diet

DIGIN MODEL

  • Digestion/Absorption
  • Intestinal Permeability
  • Gut Microbiota/Dysbiosis
  • Inflammation/Immune
  • Nervous System

Thinking Through the Case: What is the Priority?

  • Enzyme Insufficiencies
  • Dysbiosis
  • Food Allergies or Sensitivities
  • Other food reactions:

histamines, MSG, sulfates

Main GI Therapeutic Dietary Plans

Digestion/Absorption: Enzyme Insufficiencies

  • Lactose intolerance
  • Fructose Intolerance

Microbiome: Dysbiosis Diets: Restrict Prebiotics and Carbohydrates

  • FODMAP
  • Specific Carbohydrate Diet
  • Gut & Psychology Syndrome Diet
  • Anti-Fungal Diets

Immune/Inflammation/Increased Permeability: Food Allergy and Sensitivity: Low-Antigenic Diet

  • Gluten Free/Casein Free/Egg Free
  • Comprehensive Elimination Diet
  • Celiac Disease: Gluten Free
  • Rotation Diet
  • Low Histamine Diet
  • Renew / Paleo Immune

1 3 4 5 6 7

slide-2
SLIDE 2

1/11/2019 2

Digestion/Absorption: Enzyme Insufficiencies Lactose/Fructose Dysbiosis: Restrict Carbohydrates FODMAP/SCD/GAPS Immune/Inflammation: Food Allergy Low Antigenic Diet

Enzyme Insufficiencies

  • Lactose Intolerance
  • Fructose Intolerance
  • Sucrose Intolerance
  • Celiac?
  • Non-Celiac Gluten Intolerance??

Fructose Malabsorption

  • Hereditary fructose intolerance: affects 1 in 20,000-30,000 people. Genetic.
  • Up to 1/3 of us not very tolerant of fructose
  • Americans: 38.9 pounds per year in 2017 (+ 60.2 pounds of sucrose)
  • More common in women than men
  • 83% of people with fructose malabsorption have IBS Dx

˃ Looks just like IBS:

  • Constipation
  • Diarrhea
  • Abdominal spasms
  • Flatulence
  • Nausea

1. Ebert K, Witt H. Fructose malabsorption. Molecular and Cellular Pediatrics. 2016;3:10. doi:10.1186/s40348-016-0035-9. 2. Beyer PL, Caviar EM, McCallum RW. Fructose intake at current levels in the United States may cause gastrointestinal distress in normal adults. J Am Diet Assoc. 2005 Oct;105(10):1559-66. 3. Szilagyi A et al. Fructose malabsorption may be gender dependent and fails to show compensation by colonic adaptation. Dig Dis Sci. 2007 Nov;52(11):2999-3004. 4. USDA Food Tables: Consumption of Sweeteners 2018.

Fructose Malabsorption (FM) & Lactose Malabsorption (LM) in GI Disorders

  • Crohn’s Dx: 61% FM, 42% LM, 29% both
  • Ulcerative Colitis: 40% LM
  • Celiac Disease: 10% LM

Barrett JS, Irving PM, Shepherd SJ, Muir JG, Gibson PR. Comparison of the prevalence of fructose and lactose malabsorption across chronic intestinal disorders. Aliment Pharmacol Ther. 2009 Jul 1;30(2):165-74. doi: 10.1111/j.1365-2036.2009.04018.x.

Acceptable Fructose

  • 1 serving per day of low fructose fruits such

as: banana, orange, grapefruit, papaya, kiwi, tangerine, pineapple, cantaloupe, honeydew, ¼ cup of berries or grapes

  • Moderate amount of sucrose: sugar,

maple syrup, brown sugar, molasses

Shepherd S, Gibson, P. The Low-Fodmap Diet. New York, NY. The Experiment, LLC. 2013.

Digestion/Absorption: Enzyme Insufficiencies Lactose/Fructose Dysbiosis: Restrict Carbohydrates FODMAP/SCD/GAPS Immune/Inflammation: Food Allergy Low Antigenic Diet

8 9 10 11 12 13

slide-3
SLIDE 3

1/11/2019 3

Low FODMAP Diet

www.fodmap.com

FODMAPs = PREBIOTICS

  • Fermentable
  • Oligosaccharides (fructans, and galactooligo-

saccharides)

  • Disaccharides (lactose)
  • Monosaccharides (fructose)
  • Polyols (Sugar Alcohols: sorbitol, mannitol, malitol,

xylitol, polydestrose, isomalt)

Who Benefits from a low FODMAP diet?

  • Symptoms that may respond to the FODMAP approach include Functional

Gut Disorders such as IBS, gas, bloating, and diarrhea.

  • Should be undertaken for a minimum of 2 months.
  • Often used when someone suspects a problem with wheat/gluten but a

gluten-free diet doesn’t help as much as we would want (they are still eating FODMAPs and having symptoms).

FODMAPs alter symptoms and the metabolome of patients with IBS: a randomized controlled trial

What are the new findings?

  • Metabolic profiling of urine showed diets caused significant separation of metabolome.
  • There was an eightfold reduction in urinary histamine in the low FODMAP group.
  • Low FODMAP diet increased Actinobacteria richness and diversity and high FODMAP diet

decreased the relative abundance of bacteria involved in gas consumption, likely contributing to symptoms.

  • Reductions in Bifidobacterium after 4 weeks on diet.
  • Changes in gut microbiota may play a role in symptom generation in a subset of patients with

IBS; however, a low FODMAP diet might induce potential ‘unhealthy’ changes at the microbial level but requires long-term studies.

McIntosh K, Reed DE, Schneider T, Dang F, Keshteli AH, De Palma G, Madsen K, Bercik P, Vanner S. FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial. Gut. 2017 Jul;66(7):1241-1251. doi: 10.1136/gutjnl-2015-311339. Staudacher HM et al. Fermentable carbohydrate restriction reduces luminal bifidobacteria and gastrointestinal symptoms in patients with irritable bowel syndrome. J Nutr. 2012 Aug;142(8):1510-8. doi: 10.3945/jn.112.159285.

The Specific Carbohydrate Diet (SCD)

www.Breakingthevisciouscycle.info

Specific Carbohydrate Diet: Children with Crohn’s Disease

  • 7 children eating an SCD diet 5-30 months

(average 4.6 +/- 10.8 months)

  • No medications
  • All symptoms “notably resolved” in 3 months
  • Labs: albumin, CRP, HCT, calprotectin normalized or significantly

improved

Suskind DL, Wahbeh G, Gregory N, Vendettuoli H, Christie D. Nutritional therapy in pediatric Crohn disease: the specific carbohydrate diet. J Pediatr Gastroenterol Nutr. 2014 Jan;58(1):87-91. doi: 10.1097/MPG.0000000000000103.

14 15 16 17 18 19

slide-4
SLIDE 4

1/11/2019 4

SCD and Pediatric Crohn’s Disease

  • 10 children enrolled, 9 completed
  • 12 week SCD diet at least 85% of calories
  • All indexes improved significantly: Harvey-Bradshaw, Lewis, PCDAI,

blinded capsule endoscopy

  • “Clinical and mucosal improvements seen in children who used

SCD for 12 and 52 weeks.”

Cohen SA, Gold BD, Oliva S, Lewis J et al. Clinical and mucosal improvement with specific carbohydrate diet in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2014 Oct;59(4):516-21. doi: 10.1097/MPG.0000000000000449.

IBD: Crohn’s Disease and Ulcerative Colitis

  • 40 patients with Crohn’s Disease and Ulcerative Colitis
  • 27 went on diet:

˃ 24 had significant changes in HBI and CDAI ˃ 3 had ambivalent or negative response

  • Used a 4-phase dietary

approach

Olendzki BC et al. An anti-inflammatory diet as treatment for inflammatory bowel disease: A case series report. Nutrition Journal. 2014;13(1):5. doi:10.1186/1475-2891-13-5.

Digestion/Absorption: Enzyme Insufficiencies Lactose/Fructose Dysbiosis: Restrict Carbohydrates FODMAP/SCD/GAPS Immune/Inflammation: Food Allergy Low Antigenic Diet

Whole Foods/Mediterranean Diet Gluten Free / Casein Free 6 Food Elimination Diet Comprehensive Elimination Diet Paleo- Immune Elemental Diet

Six-Food Elimination Diet

AVOID

  • Cows milk
  • Soy
  • Wheat
  • Egg
  • Peanut/Tree Nuts
  • Shellfish

Gonsalves N, Yang G, Doerfler B et al. A prospective trial of six food elimination diet and reintroduction of causative agents in adults with eosinophilic esophagitis (EE). Gastroenterology. 2008;134(4):S1A104-105. Empiric 6-food elimination diet induced and maintained prolonged remission in patients with adult eosinophilic esophagitis: a Prospective study on the food cause of the disease Lucendo A, Arias Á, González-Cervera J, et al. Empiric 6-food elimination diet induced and maintained prolonged remission in patients with adult eosinophilic esophagitis: A prospective study on the food cause of the disease. The Journal of allergy and clinical immunology. 2013;131(3):797–804.

6 Food Elimination Diet for EoE

  • Forty-nine (73.1%) patients exhibited significant reduced eosinophil

counts (< 15 eos/hpf) ˃ A single offending food was identified in 35.71% of patients ˃ 2 triggers…in 30.95% and 3 or more triggers in 30.95%

  • Cow’s milk was the most common food antigen (61.9%), followed by

wheat (28.6%), eggs ( 26.2%) and legumes 23.8%)

  • Prior allergy testing showed NO CONCORDANCE with food reintroduction

challenge results.

20 21 22 23 24 25

slide-5
SLIDE 5

1/11/2019 5

Remission of EoE

  • Demonstrates for the first time that continued

avoidance of offending foods from the diets of patients with quiescent EoE can lead to a maintained disease remission in terms of symptoms and eosinophilia inflammation up to 3 years.

  • Food allergy tests based on demonstrating an IgE-

driven hypersensitivity showed limited usefulness in identifying EoE triggers.

Gonsalves N, Yang G, Doerfler B et al. A prospective trial of six food elimination diet and reintroduction of causative agents in adults with eosinophilic esophagitis (EE). Gastroenterology. 2008;134(4):S1A104-105.

Low Histamine Diet for EoE?

  • Histamine Intolerance
  • No diet research yet, but histamine-

producing cells (including mast cells & basophils) have been implicated in EoE & evidence of altered histamine receptor expression has been found

  • Research on eczema, hives, diarrhea, headache, asthma, pruritic, flushing
  • Main foods to avoid: Leftovers, any cultured or fermented food, fish

unless really fresh, alcohol, mature cheese, smoked meats, sausages, nuts, chocolate

Merves J, Chandramouleeswaran PM, Benitez AJ, et al. Altered Esophageal Histamine Receptor Expression in Eosinophilic Esophagitis (EoE): Implications on Disease Pathogenesis. Andl CD, ed. PLoS

  • ONE. 2015;10(2):e0114831. doi:10.1371/journal.pone.0114831.

Paleo Immune: Allowed foods

Protein

  • Animal protein
  • Eggs
  • Protein Powders
  • Beans/Pulses
  • Hemp protein

Vegetables

  • All non-starchy vegetables

Fruit

  • Berries, cranberries,

cherries, kiwi, pomegranate

Nuts and Seeds: All Oils and Fats:

  • Avocado
  • Coconut oil and milk
  • Ghee (clarified butter)
  • Butter
  • Olives and olive oil
  • Sesame

Dairy Alternatives

(unsweetened)

  • Coconut kefir
  • Coconut yogurt
  • Nut or seed milk

Konijeti, G. G., Kim, N., Lewis, J. D., Groven, S., Chandrasekaran, A., Grandhe. S., … & Torkamani, A. Efficacy of the autoimmune protocol diet for inflammatory bowel disease. Inflammatory Bowel Disease, 23(11), 2054-2060.

Paleo Immune: Allowed foods

Beverages

  • Water
  • Broth/Stock
  • Seltzer
  • Tea: decaffeinated green

tea, herbal teas

  • Coconut water kefir
  • Freshly made vegetable

juice Herbs and Spices Condiments

  • Coconut amino acids
  • Lemon & Lime juice
  • Miso
  • Mustard (stone ground)
  • Tamari
  • Vinegars (apple cider,

balsamic, etc.)

Restoration Diet: Someone who has malabsorption, maldigestion

  • Medical Foods
  • Bone broths
  • Pureed foods
  • Poi
  • Soups
  • Animal protein: Stews, soups, slow cooked,

pureed, marrow, eggs

  • Vegetables: juiced, well-cooked, pureed
  • Fruits: Really ripe fruit, cooked fruit, puree
  • Fats: Coconut oil, ghee, olive oil, avocado
  • Grains: Congee (Rice porridge)
  • Fermented: Goat or sheep kefir, coconut kefir, kraut juice,

sauerkraut, umeboshi plums

Restoration Diet, continued 26 27 28 29 30 31

slide-6
SLIDE 6

1/11/2019 6

Elemental Diet

  • Used for people with malabsorption, for rest and healing
  • Hypoallergenic, predigested, easily absorbed and assimilated
  • Free amino acids, MCT, glucose or maltodextrin, vitamins, minerals
  • Utilized for Eosinophilic Esophagitis, IBD,

refractory celiac, pancreatitis, SIBO, Short Bowel Syndrome, aspiration pneumonia, pouchitis, radiation induced mucosal damage

  • TREATMENT FOR DYSBIOSIS

Elemental Diet: Barriers

  • No food for 2-3 weeks
  • Taste
  • Weight loss potential

Elemental Diet

for treating SIBO

Elemental Formulas

Flavored:

  • Peptamen
  • Neocate Jr. /Splash
  • Integrative Therapeutics /

Physicians Elemental Diet Unflavored:

  • Vivonex Plus
  • Vivonex RTF

Alison Siebecker’s Homemade Recipe:

  • Amino Acid powder 45-55

gm/day

  • Carbohydrate: honey, dextrose

(glucose) glucose flavored liquid, grape syrup

  • Fat: MCT or coconut oil
  • Multi-vitamin with minerals

without fiber or additions

Siebecker, A. Elemental Formula: Options for homemaking (n.d.) http://www.siboinfo.com/elemental-formula.html

Main GI Therapeutic Dietary Plans

Digestion/Absorption: Enzyme Insufficiencies

  • Lactose intolerance
  • Fructose Intolerance

Microbiome: Dysbiosis Diets: Restrict Prebiotics and Carbohydrates

  • FODMAP
  • Specific Carbohydrate Diet
  • Gut & Psychology Syndrome Diet
  • Anti-Fungal Diets

Immune/Inflammation/Increased Permeability: Food Allergy and Sensitivity: Low-Antigenic Diet

  • Gluten Free/Casein Free/Egg Free
  • Comprehensive Elimination Diet
  • Celiac Disease: Gluten Free
  • Rotation Diet
  • Low Histamine Diet
  • Renew / Paleo Immune

Specialized Diets for GI Healing: Allowed Foods & Forbidden Foods

Comprehensive Elimination Diet Gluten Free/ Casein Free Specific Carbohydrate Diet Gut & Psychology Syndrome Diet Anti-Fungal Diet FODMAP Diet Restoration Diet Protein ALL unprocessed meats: chicken, turkey, duck, goose, quail, ostrich, fish, shellfish, lamb, venison, rabbit, eggs. Wild game. ALL unprocessed meats ALL unprocessed meats: beef, pork, chicken, turkey, duck, goose, quail, ostrich, fish, shellfish, lamb, venison, rabbit, eggs. Processed meats that do not have any SCD forbidden ingredients Eggs, fresh (if tolerated) Fresh meats (not preserved), fish, shellfish Broths with every meal. Canned fish in oil or water only ALL unprocessed meats: beef, pork, chicken, turkey, duck, goose, quail, ostrich, fish, shellfish, lamb, venison, rabbit, eggs. Tofu, tempeh, Texturized vegetable protein All unprocessed meats Eggs All unprocessed meats in small amounts: Pureed, well-cooked, stews, soups. Dairy Products & Dairy Alternatives NONE Dairy alternatives are allowed: coconut, hemp, rice, soy NONE Dairy alternatives are allowed: nut, coconut, hemp, rice, soy . All natural cheeses except for: ricotta, mozzarella, cottage cheese, cream cheese, feta, processed cheeses and spreads. Homemade yogurt cultured 24 hours. All natural cheeses Yogurt-homemade Eggs, plain yogurt (cow, sheep, goat) with live cultures,

  • rganic soy milk, soy

cheese, coconut milk, unaged goat cheese Lactose-free dairy products: milk, cottage cheese Rice milk, almond milk, hemp milk Goat milk or sheep milk kefir. Dairy alternatives as coconut kefir Fats & Oils Sunflower, olive, flax, ghee, coconut, avocado, nut oils. ALL Avocados, olive oil, coconut oil, corn oil, avocado oil, etc. Butter, ghee, coconut, avocado oil, olive ALL ALL Ghee, coconut, olive, Sam Queen’s restorative ghee Nuts & Seeds Coconut, pine nuts, chia seeds, flaxseeds, almonds, Brazil nuts, walnuts, chestnuts, filberts, pecans, nut flours, and meals ALL that are non-processed with dairy or gluten. Almonds, Brazil nuts, walnuts, chestnuts, filberts, pecans, nut flours and meals Almonds, avocado, Brazil nuts, coconut, filberts, walnuts, chestnuts, pecans, nut flours and meals, peanuts, nut butters ALL Nuts & Seeds in moderation Nut butters in moderation, Psyllium Butters

Low-FODMAP Diet Specific Carbohydrate Diet Renew Food Plan

Level of restriction High High High Eliminates Foods that are fermentable and high in

  • ligosaccharides, disaccharides,

monosaccharides, and polyols Cereal grains, processed meats, fruit juices, most dairy, tubers/starchy vegetables, refined sugar All sweeteners (refined sugars, natural & artificial sweeteners), processed foods, dairy, gluten, grains, alcohol, caffeine, saturated animal fats, most legumes, shellfish/tuna, soy Emphasizes Low-FODMAP vegetables (ex: carrots, cucumber), fruit (cantaloupe, strawberry), dairy (hard cheeses, feta), protein (eggs, poultry), grains (oats, quinoa), nuts/seeds (pepitas, walnuts) Non-starchy vegetables, fruit, honey, some dairy, meat, nuts/seeds, oils, broths, yogurt and possible legumes Non-starchy vegetables, eggs, fish, some fruits, healthy fat, lean meat, nuts/seeds, and dairy alternatives Clinical Indications (Who benefits?) IBS, gas, bloating, diarrhea, those who have suspected gluten sensitivity but don’t improve with GF diet Crohn’s disease (particularly in children), IBD, dysbiosis, disaccharidase deficiency, those for whom the elimination diet has failed A “reboot” for patients with autoimmune, GI, neurological, and

  • ther chronic health conditions

Timeframe Minimum 2 months elimination, with at least 5 additional weeks of re-

  • introduction. Some foods may need to

be removed indefinitely if symptoms are provoked with re-introduction. Some foods removed for up to 6 months, while others can be re-introduced following improvement of GI symptoms Usually short term for 2-3 weeks

Summary: GI Specific Food Plans 32 33 34 35 36 37

slide-7
SLIDE 7

1/11/2019 7

Restoration Diet Elemental Diet Anti-Fungal Diet

Level of restriction Low High Moderate-High Eliminates Raw veggies, under-ripe fruit, dairy, processed foods, nightshade vegetables (tomatoes, eggplant, peppers, potato) Most solid food All sweeteners, processed meats, peas, peanuts, cashews, pistachios, cow and goat milk, high sugar fruits, grains (esp. yeasted breads), starchy vegetables, mushrooms, fermented foods, caffeine Emphasizes Medical foods, bone broths, pureed foods, poi, vegetables, fruits, quality fat, grain (congee), fermented foods, animal proteins (stews, soups, slow cooked, marrow, eggs) Elemental formulas contain amino acids, carbohydrate, fat, multivitamins and

  • minerals. Possible additions include plain

broiled chicken breast, weak herbal tea, magnesium, small amounts of stevia. Lean protein, unsweetened dairy, nuts/seeds, cold-pressed oils, non- starchy vegetables, low-sugar fruits Clinical Indications (Who benefits?) Malabsorption, maldigestion Malabsorption, eosinophilic esophagitis, IBD, refractory celiac, pancreatitis, SIBO, short bowel syndrome, aspiration, pneumonia, pouchitis, radiation induced mucosal damage History of chronic antibiotic use, immune suppression, hx of fungal infections, sugar cravings Timeframe 12 months - Indefinite Elemental formulas for 2-3 weeks, plus 4 days

  • f re-introducing foods

Generally 1-6 months, or until symptoms resolve

Summary: GI Specific Food Plans

Liz Lipski, PhD, CNS, FACN, IFMCP, BCHN, LDN Maryland Univ. of Integrative Health Director of Academic Development & Professor in MS and DCN Programs

www.muih.edu llipski@muih.edu www.innovativehealing.com

38 39 40 41