Think,then Move! Rochelle D. Schwartz-Bloom, PhD Professor of - - PowerPoint PPT Presentation

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Think,then Move! Rochelle D. Schwartz-Bloom, PhD Professor of - - PowerPoint PPT Presentation

Think,then Move! Rochelle D. Schwartz-Bloom, PhD Professor of Pharmacology Professor of Education Duke University Medical Center RD Schwartz-Bloom Duke University Sensory Motor From: Neuroscience, Sinauer Press RD Schwartz-Bloom


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Duke University RD Schwartz-Bloom

Think,then Move!

Rochelle D. Schwartz-Bloom, PhD Professor of Pharmacology Professor of Education Duke University Medical Center

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Duke University RD Schwartz-Bloom

Motor ¡ Sensory ¡

From: Neuroscience, Sinauer Press

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Duke University RD Schwartz-Bloom

Think,then Move!

From: Backyardbrains.com

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Duke University RD Schwartz-Bloom

Biology: Neurons do the work

From: Understanding FASD: A Comprehensive Guide http://sites.duke.edu/rise/resources/teaching-material/

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Duke University RD Schwartz-Bloom From: Animated Neuroscience & the Actions of Nicotine, Cocaine, & Marijuana in the Brain

Biology: Acetylcholine is the key

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Duke University RD Schwartz-Bloom

Na+ K+ Cl-

  • 70 mv
  • utside

inside = other anions

  • - - - - - - - - - - - - - -

+++++++

Chemistry & physics: It’s the ions!

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Duke University RD Schwartz-Bloom

Biology, chemistry & physics: Currents flow

Adapted from: Neuroscience, Sinauer Press

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Duke University RD Schwartz-Bloom

mv

Physics: Currents lead to Action Potentials!

Adapted from: Neuroscience, Sinauer Press

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Duke University RD Schwartz-Bloom

How about some real Action Potentials! Let’s “grip and squeeze”

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Duke University RD Schwartz-Bloom

Real Action Potentials: grip and squeeze

Weak: 1 motor unit

AP

Moderate: > frequency more motor units Strong: high frequency random firing

From: RA Mezzarine et al., (2013) DOI: 10.5772/54870

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Duke University RD Schwartz-Bloom

Let’s do it! Muscle fatigue: What happens to the APs?

From: Backyardbrains.com

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Duke University RD Schwartz-Bloom

Let’s quantitate what happens: Use your iphone, iPad, computer!

Measurement ¡ Rest ¡ Grip ¡2me-­‑1 ¡ Grip ¡2me-­‑2 ¡ Grip ¡2me-­‑3 ¡ Amplitude ¡(mm) ¡ Frequency ¡(Hz) ¡