The selective RNA-binding protein QKI: a key player in glia - PowerPoint PPT Presentation

Mar 18, 2024 •110 likes •147 views

The selective RNA-binding protein QKI: a key player in glia development and myelination Proliferation Differentiation Myelination QKI QKI Diseases relevant to QKI function: Myelin repair in multiple sclerosis White matter impairment in

The selective RNA-binding protein QKI: a key player in glia development and myelination Proliferation Differentiation Myelination QKI QKI Diseases relevant to QKI function: Myelin repair in multiple sclerosis White matter impairment in schizophrenia Glioma tumorigenesis
QKI transgene (tg) rescues impaired myelinogenesis and axonal degeneration in the qk v mutant Axonal degeneration control q/q q/q failure of myelinotion q/q tg q/q tg Zhao ¡et ¡al., ¡J ¡Neurosci ¡26:11278 ¡, ¡Zhao ¡et ¡al., ¡PNAS ¡107:19061;Ϳ Mandler ¡et ¡al., ¡Nucleic ¡Acids ¡Res ¡42:7319
Posttranscriptional dysregulation in neuronal and oligodendroglia in psychiatric disorders Alternative splicing alternative splicing QKI-dependent mRNA homeostasis and translation in oligodendroglia governs expression of schizophrenia risk factors and myelin formation Long non-coding RNA (lncRNA) governs nuclear function of neuronal splicing factors, which in turn controls alternative splicing of schizophrenia risk factors key for neuronal network development

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