The selective RNA-binding protein QKI: a key player in glia - - PowerPoint PPT Presentation

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Mar 18, 2024 110 likes •148 views

The selective RNA-binding protein QKI: a key player in glia development and myelination Proliferation Differentiation Myelination QKI QKI Diseases relevant to QKI function: Myelin repair in multiple sclerosis White matter impairment in

SLIDE 1

The selective RNA-binding protein QKI: a key player in glia development and myelination

QKI

Myelination

QKI

Diseases relevant to QKI function: Myelin repair in multiple sclerosis White matter impairment in schizophrenia Glioma tumorigenesis

Differentiation Proliferation

SLIDE 2

QKI transgene (tg) rescues impaired myelinogenesis and axonal degeneration in the qkv mutant

control q/q q/q tg

failure of myelinotion Axonal degeneration

q/q

q/q tg

Zhao ¡et ¡al., ¡J ¡Neurosci ¡26:11278 ¡, ¡Zhao ¡et ¡al., ¡PNAS ¡107:19061;Ϳ Mandler ¡et ¡al., ¡Nucleic ¡Acids ¡Res ¡42:7319

SLIDE 3

Posttranscriptional dysregulation in neuronal and oligodendroglia in psychiatric disorders

Long non-coding RNA (lncRNA) governs nuclear function of neuronal splicing factors, which in turn controls alternative splicing of schizophrenia risk factors key for neuronal network development

alternative splicing

Alternative splicing QKI-dependent mRNA homeostasis and translation in oligodendroglia governs expression of schizophrenia risk factors and myelin formation