Summary of Changes Slide 36 graph Should be labeled 4mcg/ml and 2 - - PowerPoint PPT Presentation

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Mar 01, 2024 339 likes •390 views

Summary of Changes Slide 36 graph Should be labeled 4mcg/ml and 2 mcg/ml NOT 2mcg/ml and 1 mcg/ml Half-life still 7.5 hours Slide 38 Substitute 4 mcg/ml for 2mcg/ml and 2 mcg/ml for 1mcg/ml Answer is still the same

SLIDE 1

Summary of Changes

Slide 36 – graph

– Should be labeled 4mcg/ml and 2 mcg/ml NOT 2mcg/ml and 1 mcg/ml – Half-life still 7.5 hours

Slide 38

– Substitute 4 mcg/ml for 2mcg/ml and 2 mcg/ml for 1mcg/ml – Answer is still the same

SLIDE 2

GRAPH OF GENTAMICIN PLASMA CONCENTRATION vs.TIME

1.2 2.5 6.2

0.1 1.0 10.0

2 4 6 8 1 1 2 1 4 1 6 1 8 20 22 24

Time Post End of Infusion (hours) Gentamicin Plasma Conc. (mcg/ml)

4 mcg/ml 2 mcg/ml 6h 13.5h

t1/2 = 7.5 h

SLIDE 3

Elimination Rate Constant (k) Elimination Rate Constant (k)

k is the (-) slope of the “Natural Log (LN)

Concentration versus Time Plot”

(-) slope = ⇒ LN(2) – LN(4) 13.5 - 6 k = Δ Y axis Δ X axis ⇒

(LN(4) - LN(2)

⇒

(6 -13.5)

Simplifying

⇒ LN(4/2 ) 7.5hr k = k = LN(2) = 0.693 = 0.09 hr

7.5 hr