Spring 2016 Principles of Neurophysiology (BIONB/BME/ECE 4910) - - PowerPoint PPT Presentation

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Spring 2016 Principles of Neurophysiology (BIONB/BME/ECE 4910) - - PowerPoint PPT Presentation

Jan 20, 2023 33 likes •173 views

Spring 2016 Principles of Neurophysiology (BIONB/BME/ECE 4910) Lecture: 106 Comstock Hall; Lab: B150 Comstock Hall Web Site: http://courses.cit.cornell.edu/bionb4910/index.html *Blackboard * Instructors: Dr. Bruce Johnson, Yi-Yun Ho, Joannalyn

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Spring 2016 Principles of Neurophysiology (BIONB/BME/ECE 4910) Lecture: 106 Comstock Hall; Lab: B150 Comstock Hall Web Site: http://courses.cit.cornell.edu/bionb4910/index.html *Blackboard * Instructors: Dr. Bruce Johnson, Yi-Yun Ho, Joannalyn Delacruz Teaching Assistant: Irwin Tendler

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  • 1. Gain an intuitive understanding for important concepts in Cellular Neurobiology.
  • 2. Gain experience and competence in electrophysiological techniques (Job Skills!)
  • 3. Understand and appreciate the experimental paradigms of the field.
  • 4. Polish your scientific thinking and writing.
  • 5. Appreciate the personal excitement of a research physiologist interacting with a

living system. What’s a Model System? What are the main research model systems?

4910 Course Objectives

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Fab 4 Research Model Systems (not to scale!) Why are invertebrate animals used as model systems to teach signal transmission in human nervous systems?

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Reasons to use invertebrates for teaching neuroscience

  • 1. Evolutionary conservation of excitability and synaptic transmission
  • 2. Inexpensive to buy and maintain
  • 3. No animal protocols (no IAUCUC)
  • 4. Hardy nervous systems
  • 5. Often cultured for food
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500 million

Neuronal excitability and synaptic trans- mission changed little in a half-billion years

Hille, 2001

"Never the less, all living things are about the same" C. Darwin

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Spring 2016 Schedule

0.0 0.4 0.2

  • 0.2
  • 0.4
  • 0.6
  • 0.8

100 200 300 400 500

Time (ms) Amplitude (mV) Telson stimulated

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4910 Schedule (cont)

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Required “Texts”

Wyttenbach, R.A., Johnson, B.R. and R.R. Hoy (2014) Crawdad: An Online Lab Manual for Neurophysiology. Sinauer Associates, Inc. Sunderland, MA. http://www.sinauer.com/crawdad-an-online-lab-manual-for-neurophysiology.html Moore, J.W. and A.E. Stuart (2007) Neurons in Action, Vers. 2, Sinauer Associates, Inc., Sunderland, MA (http://www.sinauer.com/catalog/neuroscience/neurons- in-action-2-tutorials-and-simulations-using-neuron.html ) “Order from the website for a 15% discount from the suggested list price as reflected in “price to individuals” and free standard shipping to US addresses on orders over $40.00.*

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  • A. ¡ 35%- Lab Reports
  • B. ¡ 15%- Problem Sets and Other Assignments
  • C. ¡ 20%- Midterm Paper
  • D. ¡ 30%- Final Paper (25%) and Presentation (5%)

Submit to BLACKBOARD!

4910 Grading

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Lab exercise Results Due Report Due

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  • A. ¡35%- Lab Reports
  • B. ¡ 15%- Problem Sets and Other Assignments
  • C. ¡20%- Midterm Paper
  • D. ¡ 30%- Final Paper (25%) and Presentation (5%)

4910 Grading

Blackboard; Neuronal Simulation Assignments

Tutorial Assignment Page Due Date Assignment 1: Introduction to NIA 1 January 30 The Membrane Tutorial 9

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  • A. ¡35%- Lab Reports
  • B. ¡15%- Problem Sets and Other Assignments
  • C. ¡20%- Midterm Paper
  • D. 30%- Final Paper (25%) and Presentation (5%)

4910 Grading

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  • A. ¡35%- Lab Reports
  • B. ¡15%- Problem Sets and Other Assignments
  • C. ¡20%- Midterm Paper
  • D. ¡30%- Final Paper (25%) and Presentation (5%)

4910 Grading

Extra ¡credit ¡for ¡helping ¡lead ¡lab ¡exercises ¡for ¡an ¡Engineering ¡class!

10 s 20 mV

Snail neuron

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Next week First Lab: Model Neuron membrane resistance, time constant, oscilloscope. LabChartsoftware tutorial