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Recap Alife 2008 Walter de Back Collegium Budapest Institute for - PowerPoint PPT Presentation

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Recap Alife 2008 Walter de Back Collegium Budapest Institute for Advanced Study Prebiology: Error threshold Eigen, 1971 Hypercycles on a surface Boerlijst, Hogeweg 1991 Metabolic model Czaran, Szathmary 2000 Hypercycles vs. Metabolic model

  1. Recap Alife 2008 Walter de Back Collegium Budapest Institute for Advanced Study

  2. Prebiology: Error threshold Eigen, 1971

  3. Hypercycles on a surface Boerlijst, Hogeweg 1991

  4. Metabolic model Czaran, Szathmary 2000

  5. Hypercycles vs. Metabolic model 1 / n   = ∏ n ( )   M x x i   = i i

  7. Genotype - Phenotype RNA folding

  8. Neutral networks

  9. RNA evolution

  10. RNA evolution

  11. Cellular Potts model aka Glazier-Graner-Hogeweg model ● Two-scale cellular automata model ● Cell movement / Tissue development by Differential Adhesion – Free energy bond J ij where i and j are the types of the cells – Sites changes state as to minimize free energy

  13. Gene regulation (Boolean) network Nodes have state 0 or 1 NK-network: Nodes have logical rules (gates): ● N nodes e.g. ● K connections

  14. Gene regulation (Boolean) network Sample network Activation pattern (here: periodic)

  15. Evolution of reproductive restraint Spatial self-structuring => Multi-level selection => Natural selection for less fit individuals

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