Presents Th The e Po Powe wer Of S f Syn yner ergy gy For - - PowerPoint PPT Presentation

Presents Th The e Po Powe wer Of S f Syn yner ergy gy For

• r Ac

Acti tive e Cur urcu cumi min

Low

• w Bio

io- av avai aila lability bility Of Co Conv nvent entional ional Tur urme meric ric Extr tract act

• Traditional use of turmeric –

turmeric powder in culinary applications

• Conventional turmeric extracts contain
• nly Curcuminoids
• Very low retention in blood

Turmeric, a natural immunity booster that has low bloodstream absorption Curcumin, the active ingredient in turmeric Highly bio-absorbable curcumin extract : BCM-95 8 – 12 hours retention in the bloodstream, proven by research Total 12 patents nts Pending Worldwide - 14 paten ents More than 25 publish lished ed human an clinic nical l studies dies

Story Of The World’s Only 100% Tur urme meri ric c Extr trac act t Wi With th Sup uperi erior

• r Bio

io-ac activity tivity

Ch Chemi mical cal Co Comp mposition

• sition Of Tur

urmer meric ic

Curcuminoids 2-6% Volatile oil 3-7% Carbohydrates 60-70% Moisture 6-13% Fat 5-10% Protein 6-8% Mineral matter 3-7% Fiber 2-7%

Curcuminoids

Desmethoxy curcumin Bis desmethoxy curcumin

Volatile oils

Turmerones Ar-turmerone Most active ingredient in turmeric, but very poor in oral bio availability

1 2 1 2

Enh nhanc ncin ing The he Power er Of Cu Curcu cumin in Thr hrough h Syne nerg rgism ism

AR AR-TUR URMERON ONE CURCUM UMIN 100% Turmeric Extract

PO POWE WER R OF OF SYN SYNER ERGY GY FO FOR ACT CTIV IVE E CUR CURCUM CUMIN IN

Human Crossover Study to evaluate Bio- availability of BCM–95, Indian journal of pharmaceutical sciences, July – August 2008, 445 - 449

BCM–95 is 6.93 times more bio-available than Curcumin

Oral al Bio ioav availability ailability

Mech chanism anism of

• f e

enh nhan ance ced d cu curcu cumi min n bio ioavai availability lability

Functio ction n

• Pumps xenobiotocs out of cells into intestinal lumen
• leads to reduced absorption and low bioavailability

Role e of Pgp in curcumin min absorptio ption

• Increase the outflow (efflux) of curcumin into intestinal

lumen

• Hence poor bioavailability

How w does turmer merone

• ne help
• Turmerones

erones are inhib ibitors itors of Pgp

• Prevent the efflux of curcumin back to intestine
• Thereby increase the bioavailability of curcumin in body

Conclusion clusion

• Curcumin is better bioavailable in presence of

turmerones

P glycoprotein (Pgp)- an important protein of cell membrane , widely distributed in intestine

Refere erence nce: : The Role of Turmerones on Curcumin Transportation and P-Glycoprotein Activities in Intestinal Caco-2 Cells, J Med Food 15 (3) 2012, 242–252

Cu Curcu cuminoi minoids ds Ar Ar Tur urmer merone

• ne

At the low dose, Turmerones markedly suppressed adenoma multiplicity by 73% Curcumin at both doses suppressed adenocarcinoma multiplicity by 63-69% Combination of Curcumin and Turmerone at both low/high doses abolished tumor formation

DMH : Dimethyl hydrazine; DSS: Detran sulfate sodium

Curcumin + Turmerones, abolishes inflammation in colon carcinogenesis.

Treat atment nt Incid idenc nce (%) % Inhibit itio ion n of multipl iplic icit ity y Adeno noma a Adeno noca carcin rcinoma

• ma Adeno

noma a Adeno noca carcin rcinoma

• ma

DMH/DSS 88 88

• DMH/DSS+20 ppm TUR

22 67 73 57 DMH/DSS+100 ppm TUR 50 100 45 32 DMH/DSS+1000 ppm CUR 22 50 59 69 DMH/DSS+5000 ppm CUR 50 50 59 63 DMH/DS DSS+20 +20 ppm ppm TUR & 1000 ppm ppm CUR 100 100 100 100 DMH/DS DSS+10 +100 0 ppm TUR & 5000 ppm CUR 100 100 100 100 No treatment

• Referen

ence: ce: Murakami et al, Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis. Biofactors. 2013;39(2):221-32.

Syner nergistic istic Effect ct Of

Curcuminoids and sesquiterpenoids in turmeric suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. .

Blood glucose level in KK-Ay mice fed diet alone (Cont) or diet containing curcuminoids (C), Turmerones (T) or combination of C + T

Reference: Nishiyama et al, Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. J Agric Food Chem. 2005; 53 (4): 959-63.

Results indicated that turmeric extract containing both curcuminoids and sesquiterpenoids was more strongly hypoglycemic than either curcuminoids or sesquiterpenoids.

Syner nergistic istic Effect ct Of Cu Curcu cumin minoids

• ids

Ar Ar Tur urmer merone

• ne

• Enha

hanc nced ed bioavailability and reten ention ion in blood

• High bioactivity at lower doses
• 100%

100% characterised composition

• Safet

fety proven by detailed toxicity study

Salient ent Fea eature ures

• GRAS

AS Affirmed

• Halal

al and Koshe her Certified

• GMP Certified
• ISO 22000

0 Certified

• Conforms to California’s Proposition 65 stringent

stand ndar ards ds

• Produced using only cl

clean an sol

• lar

ar energy

Contd…

• Compl

plies ies to

• BAP and PAH4 limit

it as per new EU regulation EC/1933/2015.

• Acceptable intake of residual solvents guideline set BY EU where

e Class s 3 solven vents s are used which is considered to be Solvents with low toxic ic poten ential. ial.

• Regulation (EC) No 396/200

2005 5 of the European Parliament and of the Council of 23 February 2005 on maximum residue levels of pesticides

• Regulation (EC) No 1881/200

2006 6 of 19 December 2006 setting maximum levels for certain contaminants such as Heavy Metals (lead, cadmium, mercury, tin) in food ingredients.

• Adheres

eres to EU regulation on maximum level of Aflatoxins in food ingredients.

Bio io Ava vail ilab ability ility Enh nhan ance ceme ment nt – Oth ther r Bran ands ds

Curcu cumin + P Pipe perine

• Bloodstream retention for a very short time
• Long- term health safety concerns

Curcu cumin + P Phos

• sph

phatidy atidyl l Chol

• line
• Curcumin not detected
• Only C glucuronide and sulfate

Curcu cumin + S Soy

• y Le

Leci cith thin

• Very low levels detected

Na Nanocu curcu cumin

• Long term health safety concerns

Oth thers

• Combination of curcumin with vanillin,

sustained release, etc.

• No scientific proof, unrealistic claims

Li Liqu quid d Bas ased Curcu cumin

• Low levels of curcumin and very high

levels of emulsifier

• Studies conducted on liquid product and

capsules ( powder)

Bio io Av Avai aila labil bility ity Enh nhan ance cemen ment t – Oth ther r Bran ands ds

Curcu cumin + P Pol

• lyv

yvinyl yl py pyrrol

• lidon

done e (P (PVP) )

• Contains upto 75% PVP - a synthetic

binder allowed only 10% in supplement by FDA

• Measured only C metabolite

In Indic ications ations Fo For Us Use

CANCE CER DEPRES PRESSIO SION ALZHEMER’S DISEASE INFLAM LAMMAT ATION ON DIABE ABETES ES AUTOIM OIMMUN UNE E DISE SEASE SES ARTHRI HRITIS NEUROLOGI UROLOGICA CAL L DISE SEASE SES PULMONARY RY & GIT DIES ESEAS ASE

Benefits efits :

• Synergism with modern drugs
• Works as adjuvant
• Effective as single agent
• Reduces side effects

General ral Dos

• sag

age e 500 mg twice daily

Depression –

• 2 human studies published, 1 ongoing in Australia
• Dosage : 500 mg twice daily

Clinically Documented Indications

Rheumatoid arthritis -

• 1 human study published, 1 ongoing in India
• Dosage : 500 mg twice daily

Osteoarthritis -

• 1 human study published, 1 human study completed
• Dosage : 700 – 1000 mg/day

Othe her r scientif ntific ically ally documente mented d areas : Alzheimers disease, Prostate cancer, Sub mucous fibrosis, Leukoplakia, Adjunct to radiotherapy Ongoing

• ing human

n studies dies : 3 studies in US, 1 in EU, 2 in Australia, 1 in India

Produc

• duct

t Ava vail ilab ability ility Gr Grad ades es

• BCM-95 CG : Capsule Grade
• BCM-95 SG : Soft Gel Grade
• BCM-95 DC : Direct Compressible
• BCM-95 : Water Dispersible

Soft t Gels Efferv rvescent scent Tablets ets Cand ndy y Capsule ules Tablets ets

App pplic lications ations

Ready y to drink powder r mix

Spe pecif cifications ications

Contd…

Contd…

• BCM-95 Curcumin was selected as a finalist at the Nutr

tra a Ingredi dien ents s Awards s , 2015 ( In association with Vitafoods Europe 2015 & organized by NutraIngredient.com ) under the " Readers’ of the Year " and " Unive versit sity Resear arch ch of the Year " category

Awards ards an and recogn cognitions itions

Shortlisted for Most Innovative Ingredient at Nutraingr ingredi edients ents Award, 2015- Europe

Aw Awards ards an and reco cogni gniti tions

• ns

Maj ajor

• r

Glo loba bal l Cli lien ente tele le

Contd…

Contd…

Contd…

Trus usted ted by by Bran ands s Wo Worldw ldwide ide

Tha hank nk you

• u