Powering Implantable Medical Devices Dr. Sujeet Kumar - - PowerPoint PPT Presentation

Powering Implantable Medical Devices

• Dr. Sujeet Kumar

MIT•Stanford•UC Berkeley Nanotechnology Forum October 6, 2005

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About Us

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Highlights

Founded by Wilson Greatbatch in 1970; IPO in 2000 (NYSE: GB) Leading component supplier to the Cardiac Rhythm Management (CRM) industry High growth medical technology market Proven product portfolio of technology leadership products Pipeline of emerging technology opportunities

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Critical Component Supplier

Batteries Capacitors Commercial Batteries Feedthroughs Enclosures Coated Electrodes EMI Filters Engineered Components Value Add Assembly

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Corporate Strategy

Maintain a strong new product pipeline with advanced proprietary technology Leverage manufacturing and assembly capabilities to provide best value solution Drive quality improvements throughout product life cycle Broaden traditional customer interface

Technology Manufacturing Quality Customer Commercialization

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Facility Locations

Tijuana, MX Fremont, CA Carson City, NV Minneapolis, MN Western NY Canton, MA Columbia, MD

• 1. Advanced Power Source Plant
• 2. Battery Plant / R&D Center
• 3. Capacitors Plant
• 4. Machined and Molded Components Plant
• 5. Destructive Analysis Facility
• 6. Sales & Marketing Facility
• 7. Headquarters Facility
• 9. Feedthrough and Coatings Plant
• 12. Advanced Research Lab (Nanomaterials)
• 11. Filtered Feedthrough Plant
• 8. Commercial Battery Plant
• 13. Assembly Plant
• 10. Enclosure Plant

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Sales

83.8 14.0 27.9 25.4 26.1 27.4 190.2 172.7 141.9 107.7

50 100 150 200 250 2000 2001 2002 2003 2004

Full Year Guidance Electrochem Commercial Power Implantable Medical Components

$ Millions

* Represents midpoint of Management’s guidance dated May 3, 2005

$200.1M $97.8M $135.6M $167.3M $216.3M

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Market & Products

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CRM Market

Market that deals with electrical problems of the heart

Bradycardia/Tachycardia Congestive Heart Failure Sudden Cardiac Death

Estimated $11 billion market in 2006

80% of Greatbatch revenues driven by CRM

Customer concentration

Medtronic Guidant

• St. Jude Medical

Biotronik ELA

30% 10% 36% 24%

Guidant

• St. Jude Medical

Medtronic Others

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Detects abnormally slow heart beat (bradycardia) Resynchronize ventricular contraction; now combined with ICD + pacing in one device Detects abnormally fast heart beat (tachycardia); shocks the heart to restore normal function

Function

0 – 4% 35% 10 – 15%

Unit Growth – 2005E

Cardiac Resynchronisation Therapy

Device

Pacemakers Implantable Cardioverter Defibrillators

CRM Devices – Function & Growth

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How It Works

ICD SVO Battery

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ICD Selection Criteria Closely Tied to Power Source Characteristics

Feature Set Device Lifetime Charge Times Programmer & Interface Shape Size

Role of Power Source Criterion

Source: Morgan Stanley CRM Conference 09/03

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Technology Leadership

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Silver Vanadium Oxide: Background

Battery chemistry originally developed at Greatbatch, Inc. 98% of ICDs use SVO as the high rate battery due to its combination of: High rate capability enabling faster charge times High capacity enabling longer device lifetimes Stepped discharge profile enabling easier end-of-life detection Battery function in ICD Monitor circuitry on continuous basis Charge high voltage capacitors in less than 15 seconds

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QSeries Battery Technology

Our next generation of battery that combines the advantages of two distinct cathode materials via an innovative electrode design

SVO: Low energy density but high rate capability CFx: High energy density but low rate capability

Qseries battery technology is the best implantable battery technology available today.

Technology protected by IP 5 years of real-time data

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Innovation in Nanotechnology

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NanoGram Devices Corporation

Spun out of NanoGram Corporation in August 2002 Leader in nanomaterials enhanced power sources; developed NanoSVO for implantable medical devices Raised $9.2MM in Series A financing led by Venrock, Bay Partners, and Nth Power (January 2003) Acquired by Greatbatch in March 2004 for $45MM; currently Advanced Research Laboratories

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Nanoparticle Manufacturing Technology (NPM™)

• Unique Features

Auto nucleation due to abrupt

temperature change

Size growth control due to quenching Wall free reaction zone reduces

contamination

Uniform laser reaction zone chamber

• Engineering Benefits

Flexible design of reactor by optics

Programmable control of process

• Capability

Control of grain growth

Uniform size High chemical purity

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Technology Benefits

Nozzle Length (mm) Throughput (kg/hr)

Complex compositions Highly reproducible Controlled properties Scaleable

• --VOX 702 ---VOX 709 ---VOX 716
• --VOX 703 ---VOX 710 ---VOX 717
• --VOX 704 ---VOX 711 ---VOX 718
• --VOX 705 ---VOX 712 ---VOX 719
• --VOX 706 ---VOX 713 ---VOX 720
• --VOX 707 ---VOX 714 ---VOX 722
• --VOX 708 ---VOX 715

VO2

• --VOX 702 ---VOX 709 ---VOX 716
• --VOX 703 ---VOX 710 ---VOX 717
• --VOX 704 ---VOX 711 ---VOX 718
• --VOX 705 ---VOX 712 ---VOX 719
• --VOX 706 ---VOX 713 ---VOX 720
• --VOX 707 ---VOX 714 ---VOX 722
• --VOX 708 ---VOX 715

VO2

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NanoSVO Technology

Nanoscale version of bulk SVO Precisely tailored nanocrystalline structure yielding low impedance and high power capability

High power capability Low impedance Greater stability Smaller size Improved design flexibility

Technology Benefits

Anode Current Collector LOAD Li + Li + Li + Bulk Cathode Electrolyte +

• Anode

LOAD Li + Li + Li + Nano Cathode Current Collector Electrolyte +

• Bulk

Nano

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Higher Current or “Rate” Capability Low Impedance Shorter Charge Times Greater Capacity per Volume Longer Lifetimes

Nanotechnology Benefits Dramatic in Medical Implantable Power Source Market

“Fast Lithium Transport”

Nano-enhanced Cathode Has Better Accessibility for Lithium Ions

Contact:

• Dr. Sujeet Kumar

Ph: 510-825-0798 Email: skumar@greatbatch.com www.greatbatch.com