Pharma Packaging Through Single Parcel Shipments A STM D10 Workshop: - - PowerPoint PPT Presentation

Pharma Packaging Through Single Parcel Shipments ASTM D10 Workshop: Optimizing Packaging Performance

Mahesh Khurana & Sam Upadhyaya 11th October 2017

Content:

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• Project Goals
• Planning Phase
• Project Setup
• Test Setup
• e-value
• Shipping Routes
• Drop Results
• Orientation Results

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Project Goals:

• Gather data for Roche temperature controlled single parcel

shipments across the global distribution network:

• 1. Shocks and drops.
• 2. Package orientation during transit.

Planning Phase:

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• Planning phase included selection of:
• Field data collection instrument
• Representative shipping lanes
• Test samples
• Performing pilot shipments
• Review published literature
• Supply chain information included – dispatch volumes and sales

volumes, size and weight ranges for single parcel shipments

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Test setup

• We used Lansmont SAVER devices to monitor the shock (3X90 and

3M30+) and the orientation of package (3D15).

• Two representative packaging configurations representing high and

low end of commercial shipments’ weight & dimensions were made.

• Small Package: 14 x 10 x 10 in @ 11 lb (5kg)
• Large Package: 24 x 24 x 20 in @ 40 lb (18kg)

6 Small

Large

e-value calculation

• The coefficient of restitution (e) is the ratio of final velocity to initial

velocity after an object undergoes a collision. Therefore it is possible to calculate the drop height of the package if e is known.

• EDH is effective drop height, g is acceleration due to gravity, ΔVR is change in

velocity.

• We performed in-lab drop tests at 6 known heights, across multiple
• rientations with 3 repetitions each in order to reverse calculate e for our

package configuration.

• RESULTS: The e value for both package is calculated to be 0.6.

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Shipping Routes

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• Shipping routes were selected in six countries within North

America (N A), Europe (EU), Latin America (LATAM) and Asia.

• Six round-trips shipments were done in each country.
• Sending sites were Roche distribution center.
• Receiving sites were selected based:
• high dispatch volume,
• mode of transport (air, truck, ferry),
• geographical location within country
• Shipments were done using the same method as for commercial

Roche shipments – Courier service (like Fedex, DHL), dedicated truck etc.

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Drop data results (drops >7in only)

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Drop Data Average number of drops for

• ne-way trip globally

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• Max. drop height, in

54.6 48.2 Drop height at 99% occurrence 40.7 36.0 Drop height at 95% occurrence 24.3 28.5 Mean drop height, in 12.3 14.0 Large Package Small Package

Drop data for Large and Small package

Max 54.6 Mean 14.3 Mean 12.3 95% Occurrence 24.3 95% Occurrence 28.5 Max 48.2 10 20 30 40 50 60 70 7 9 11 13 15 17 19 21 23 25 27 29 31 33 35 37 39 41 43 45 47 49 51 53

Number of Drops Drop Heights, inch

• Avg. No.
• f drops

per one- way trip

Small Large

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Top 5 drop heights

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Drop Data Small Package Large Package

Highest drop, in 54.6 Asia 48.2 Asia 2nd highest drop, in 48.0 Asia 39.6 EU 3rd highest drop, in 42.4 Asia 33.7 N A 4th highest drop, in 40.8 Asia 31.9 NA 5th highest drop, in 40.7 Asia 31.3 Asia

Drop Impact orientation results (drops >7in only)

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Impact Orientation Face - Top 2 1 Face - Bottom 11 14 Face - Sides 5 2 Edge - Top 9 9 Edge - Bottom 23 31 Edge - Side 9 11 Corner - Top 15 12 Corner - Bottom 26 20 Large Package

Small Package

Conclusions from drop data

• Majority of drops were bottom oriented for both packages

(60% for small and 65% for large).

• Average number of drops per one-way trip were 6 for small

package and 3 for large package – (ASTM D7386 has 18 drops and D4169 has 12 drops).

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• SAVER 3D15 was mounted on the Large package to record the
• rientation of package during the transit.
• SAVER 3D15 include MEMS technology accelerometers with

DC response measurement capability.

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Set-up: Orientation data for Large package

3D15 3X90 3M30+

Orientation data for Large package

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ASIA LATAM N A EU Average

Average one-way trip duration (hours) 71 141 85 60 89

41 96 71 97 50 1 27 3 8 1 1 20 40 60 80 100

ASIA LATAM NA EU % Time on Orientation

Top Side Bottom

Orientation detail: North America

This graph shows the orientation as factor of time for North America. This graph displays the number of time the orientation changed and duration spent on certain orientation. Each color represents one round trip shipment.

Bottom Side Top

Conclusions from orientation data

• Orientation information is important to evaluate the performance of

passive temperature controlled packages. – Examples:

• Thermal packages may experience temperature excursions when
• rientation is changed.
• Understand time to failure in different orientation and compare to

normal shipping orientation (bottom).

• 2-8°C is maintained only for 24 hours when package is oriented
• n side vs. 56 hours when oriented on bottom.

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