October 18, 2017 1 / 19 converging trends Lytton UW N GR Oct 18, - - PowerPoint PPT Presentation

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October 18, 2017 1 / 19 converging trends Lytton UW N GR Oct 18, 2017 2 / 19 Climbing the omes omeomics genomes (microbiome, tumorome, virome) epigenomes (MS?) proteome (organ-specific), interactome, metabolome physiome connectome (in

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October 18, 2017 1 / 19

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converging trends

Lytton UW N GR Oct 18, 2017 2 / 19

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Climbing the omes

meomics

genomes (microbiome, tumorome, virome) epigenomes (MS?) proteome (organ-specific), interactome, metabolome physiome connectome (in neuro) etceterome

Lytton UW N GR Oct 18, 2017 3 / 19

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6 drunk blind men looking for keys

n an elephant riding on an iceberg

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Multiscale modeling

scales of investigation

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Dynamical disorders

dynamics of variability in degenerative disorders

epilepsy migraine Alzheimer? Parkinson dystonia

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River of epilepsy

modified from Lennox&Lennox

Lytton WW. Computer modelling of epilepsy Nat Rev Neurosci 2008 Lytton UW N GR Oct 18, 2017 7 / 19

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Two pathways out of M1

collaboration with Gordon WG Shepherd, Northwestern Lytton UW N GR Oct 18, 2017 8 / 19

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Detailed modeling of major cell types of Layer 5

PT==SPI

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Schematizing neocortex

NB: mouse M1 has a layer 4

Lytton UW N GR Oct 18, 2017 10 / 19

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Working out drug cocktails

motor cortex (M1) model

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Complex patterns of activity

stim lower layers

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Interpose a virtual arm

Matching carrier as well as signal?

virtual arm courtesy Xianlian Zhou & Andrzej Przekwas, CFD Research Corp, Huntsville, AL Lytton UW N GR Oct 18, 2017 14 / 19

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Robot follows virtual arm

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Reinforcement learning (RL)

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RL alters STDP effect

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Feedback from muscle lengths and forces

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