Objective Study participants To evaluate the association of - - PowerPoint PPT Presentation

9/20/2018 1

Dietary soy intake and mortality

• utcome in Chinese breast cancer

survivors

Professor Suzanne C Ho JC School of Public Health and Primary Care Chinese University of Hong Kong

Increasing BC incidence and improved outcome growing population

• f BC survivors

Breast cancer incidence and mortality in HK

Annual age‐standardized female breast cancer incidence and mortality rates in Hong Kong from 1976 to 2010 (Br J Cancer 112:167‐70, 2015) sAPC = segmented annual % change

Objective

• To evaluate the association of pre‐diagnose soy food intake with

total mortality in Chinese breast cancer (BC) survivors

• Hypothesis – high soy intake is not associated with adverse

mortality outcome

Study participants

• 1,497 BC survivors recruited since 2010 from two regional

hospitals in Hong Kong

• Inclusion criteria
• Chinese women aged 24 to 77 years
• Histologically confirmed primary breast cancer within 12 months
• f study entry
• no prior history of breast or other cancers
• Cancer stage below III

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Methods

• Interviewer‐based questionnaire
• Soy food and overall diet intake based
• n109‐item food frequency questionnaire

during the year prior to diagnosis

• Socio‐demographic, medical, reproductive

and lifestyle factors

• Prognostic characteristics (clinical records)
• Anthropometric measurements
• Data collection repeated at 18‐, 36‐, and 60‐

month followup

• Study still on‐going

2811 Incident cases of breast cancer diagnosed between 2010 and 2013 1497 Completed baseline survey 1349 Cases excluded 580 Refusals 769 Excluded for health or communication problems 18-mo Post-diagnosis follow-up 36-mo Post-diagnosis follow-up 60-mo Post-diagnosis follow-up (Ongoing)

Flow chart on subject recruitment

The Hong Kong Breast Cancer Survival Study (HKBCSS)

Outcome Measure

• All‐mortality during followup till November 2017 (mean

50.9±9.916.8 months) (78% retention rate)

• Mortality obtained from active follow‐up and computerized

clinical management system

• Adjustment made for potential confounders: age, body mass

index, education, radiotherapy, chemotherapy, ER/PR status, HER2 status, menopausal status, cancer stage and dietary energy intake

Findings

• 96 deaths (5.9% premenopausal and 7% postmenopausal)
• ccurred during followup

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Findings Summary

Our prospective study showed that

• Pre‐diagnosis soy intake did not increase the risk of all‐cause

mortality in BC survivors

• A linear dose‐response pattern till quartile 3 (6 ‐12 mag/d), while

no additional benefit beyond was observed

• Study is still ongoing longer followup will provide further

evidence on the effect of pre‐ and post‐diagnosis soy intake on BC

• utcomes

Conclusion

• No evidence to show pre‐diagnosis soy food intake increases

mortality risk among Chinese BC survivors

• Moderate soy food intake might be associated with better survival

Acknowledgements

• Team members

Winnie Yeo, Ashley Cheng, Carol Kwok, Roselle Lee, Yuan yuan Lei, Yiqian He, CK Iris Lee, KL Cheung , YM Aggie Ip

• Participants of the study
• Study supported by the World Cancer Research Fund International Grant No.

2010/249 and 2014/1197