Nutrition and Mental Health: Using PureSYNAPSE Supplements to - PowerPoint PPT Presentation

Nutrition and Mental Health: Using PureSYNAPSE ™ Supplements to Optimize Outcomes in Clinical Practice* Kelly C. Heim, Ph.D. *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Speaker Disclosure Kelly Heim, Ph.D I am a paid medical advisors for Pure Encapsulations. I have no other conflicts of interest to disclose. The Company assumes no liability for presenter’s information, whether conveyed verbally or in these materials. All presentations represent the opinions of the presenter and do not represent the position or the opinion of the Company. Reference by the presenter to any specific product, process or service by trade name, trademark, or manufacturer does not constitute or imply endorsement or recommendation by the Company. Seminars, teleconferences and webinars such as this are for educational purposes only and are intended for licensed health care practitioners. These therapies are not substitutions for standard medical care. Practitioners are solely responsible for the care and treatment provided to their own patients.

Learning Objectives 1. Learn about the significance of neurotransmission and the various neurotransmitters that influence our mind and body. 2. Understand how key neurotransmitters are synthesized 3. Learn how implementing supplements can support the synthesis of neurotransmitter and promote healthy mood, memory, behavior, cognition, sleep, stress and eating habits* *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

What is Neurotransmission? Synapse Neurotransmitter

The Role of Neurotransmitters Chemical messengers that allow communication between neurons Release of these chemicals causes electrical impulses throughout the brain and nervous system, resulting in thoughts, feelings, & behavior Key Neurotransmitters: Healthy neurotransmitter levels support:* • Serotonin • Sleep • Dopamine • Stress • GABA • Eating habits • Glutamate • Mood • Norepinephrine • Memory *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Neurotransmitters: Supporting Synthesis - Positive mood* - Moderate occasional Serotonin stress* - Relaxation and SUPPOR TS - Healthy eating behavior* calming* - Alertness* - Positive mood* Dopamine - Cognitive - Sense of reward* SUPPOR TS function* - Mood* - Sleep* GABA - Stress response* - Relaxation* SUPPOR TS *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

How Neurotransmitters are Synthesized 1. Amino acids serve as precursors for neurotransmitters 2. Vitamins and minerals serve as cofactors for enzymes that synthesize neurotransmitters Amino acid Neurotransmitter Enzyme 1 + Cofactor 2

Neurotransmitter Precursors

Amino Acids Intake is Critical for Healthy Neurotransmitter Synthesis* • Adequate protein consumption is critical Key Amino Acids • Available amino acids are dependent on Serotonin: Tryptophan healthy digestion of protein* • Protein digestion requires adequate Dopamine : Tyrosine gastric hydrochloric acid (HCl) and various proteases Phenylalanine • Betaine HCl, pepsin and digestive enzymes supports amino acid GABA : Glutamine bioavailability from dietary protein* Glutamate *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Digestive Enzymes Ultra • High-potency, broad spectrum vegetarian enzymes that support protein, carbohydrate, fat, fiber and dairy digestion and optimal nutrient bioavailability and absorption* • Proteases provide optimal activity across a wide pH range, facilitating the breakdown of proteins as well as di- and tri-peptides* *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Amino-NR Provides a natural ratio of free-form amino acids to encourage healthy neurotransmitter synthesis and support cognitive function and mood* Also includes - Alpha lipoic acid and alpha ketoglutarate to support mitochondrial function and energy* - Vitamin B6 to support healthy neurotransmitter synthesis and energy metabolism* *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Neurotransmitter Synthesis 1. Amino acids serve as precursors for neurotransmitters 2. Vitamins and minerals serve as cofactors for enzymes that synthesize neurotransmitters Amino acid Neurotransmitter Enzyme 1 + Cofactor 2 *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

The Importance of Cofactors Cofactors are vitamins and minerals Key Cofactors - Zinc Facilitate the function, stability and/or - Magnesium activity of the enzymes and receptors responsible for neurotransmitter synthesis - Folate and response* - Vitamin B6 - Vitamin B12 Cofactors are commonly depleted in individuals as a result of: • Medications • Dietary limitations • Environmental exposures *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Neurotransmitter Cofactors

The Importance of Zinc • Maintains the structure of the AADC By supporting healthy enzyme involved in the synthesis of neurotransmission zinc dopamine and serotonin* supports: • • Moderates the activity of glutamate Mood receptors to support both emotional • Focus wellness and long-term • neuroprotection* Calmness Essential for digestion: • Healthy eating habits • Increases the activity of digestive enzymes (see table) • Necessary for carbonic anhydrase activity and the formation of acid salts in the gastric mucosa *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Zinc Deficiency The Standard American Diet: - Low in zinc rich foods - High in foods with components that inhibit the absorption of zinc (e.g., iron ) Other causes: - Puberty - Stress - Vegetarianism - Exercise - Environmental toxins

Zinc: Clinical Trials Women who took a multivitamin and zinc showed significant benefit in measurements of anger-hostility and mood 1* Zinc supplemented patients had significantly improved scores for mood compared to placebo 2* Patients who are refractory to other approaches were recruited to a study, in which zinc provided significant support for mood, as evident in 4 different clinical scoring methods 3* Zinc supported mood, relaxation, healthy weight gain and taste recovery in patients with very low BMI, compared to placebo. 4* 1. Sawada and Yokol, Eur J Clin Nutr (2010) 64(3):331-3 2. Nowak et al, Pol J Pharmacol (2003) 55:1143-1147 3. Siwek et al, J Affect Disord (2009) 118(1-3):187-95 4. Katz et al., J Adolesc Health Care (1987) *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Magnesium • Maintains cytokine homeostasis and antioxidant protection in the brain and nervous system* • Inverse relationship between serum cortisol and magnesium levels* • Supports the calming actions of GABA* • Binds to the NMDA receptor, keeping glutamate/NMDA activity GABA response within healthy limits* GABA receptor *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Magnesium (glycinate) • Highly bioavailable • Less likely to cause loose stools than other forms of magnesium* • Available in capsules or a great-tasting liquid o 120 mg elemental Mg per capsule o 165 mg elemental Mg in two teaspoons *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Folate Folate • A collective term referring to folic acid and its naturally occurring analogs (mainly 5-MTHF but also 125 other different forms of folate!) • Directly utilized by the body • Significantly more bioavailable than folic acid Folic Acid • Oxidized form of folate • Not naturally found in food • Plays no direct role in any biochemical reaction, must be converted to an active form • Stability makes it preferable for food fortification

8 Major Roles of Folate Homocysteine 1. Biosynthesis of neurotransmitters* 5-MTHF 2. Myelination of neurons* B 12 3. Regulation of gene expression (epigenetics)* Methionine 4. Amino acid metabolism* 5. Division of red blood cells* SAMe 6. Prevention of neural tube defects* 7. Reduction of homocysteine* Methylation 8. DNA replication* - Neurotransmitters - DNA - Many other compounds *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.