Nutrition and Mental Health: Using PureSYNAPSE Supplements to - - PowerPoint PPT Presentation

Nutrition and Mental Health: Using PureSYNAPSE™ Supplements to Optimize Outcomes in Clinical Practice*

Kelly C. Heim, Ph.D.

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Kelly Heim, Ph.D I am a paid medical advisors for Pure Encapsulations. I have no other conflicts of interest to disclose. The Company assumes no liability for presenter’s information, whether conveyed verbally or in these materials. All presentations represent the opinions of the presenter and do not represent the position or the opinion of the Company. Reference by the presenter to any specific product, process or service by trade name, trademark, or manufacturer does not constitute or imply endorsement or recommendation by the Company. Seminars, teleconferences and webinars such as this are for educational purposes only and are intended for licensed health care practitioners. These therapies are not substitutions for standard medical care. Practitioners are solely responsible for the care and treatment provided to their own patients.

Speaker Disclosure

Learning Objectives

1. Learn about the significance of neurotransmission and the various neurotransmitters that influence our mind and body. 2. Understand how key neurotransmitters are synthesized 3. Learn how implementing supplements can support the synthesis

• f neurotransmitter and promote healthy mood, memory,

behavior, cognition, sleep, stress and eating habits*

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

What is Neurotransmission?

Synapse

Neurotransmitter

The Role of Neurotransmitters

Chemical messengers that allow communication between neurons Release of these chemicals causes electrical impulses throughout the brain and nervous system, resulting in thoughts, feelings, & behavior Healthy neurotransmitter levels support:*

• Sleep
• Stress
• Eating habits
• Mood
• Memory

Key Neurotransmitters:

• Serotonin
• Dopamine
• GABA
• Glutamate
• Norepinephrine

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Neurotransmitters: Supporting Synthesis

Serotonin

• Positive mood*
• Relaxation and

calming*

• Moderate occasional

stress*

• Healthy eating behavior*

SUPPOR TS

Dopamine

• Alertness*
• Cognitive

function*

• Positive mood*
• Sense of reward*

SUPPOR TS

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

GABA

• Mood*
• Stress response*
• Sleep*
• Relaxation*

SUPPOR TS

• 1. Amino acids serve as precursors for neurotransmitters
• 2. Vitamins and minerals serve as cofactors for enzymes that

synthesize neurotransmitters

1

Neurotransmitter Amino acid

Enzyme + Cofactor

2

How Neurotransmitters are Synthesized

Neurotransmitter Precursors

Amino Acids Intake is Critical for Healthy Neurotransmitter Synthesis*

Key Amino Acids

Serotonin: Tryptophan Dopamine: Tyrosine Phenylalanine GABA: Glutamine Glutamate

• Adequate protein consumption is critical
• Available amino acids are dependent on

healthy digestion of protein*

• Protein digestion requires adequate

gastric hydrochloric acid (HCl) and various proteases

• Betaine HCl, pepsin and digestive

enzymes supports amino acid bioavailability from dietary protein*

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Digestive Enzymes Ultra

• High-potency, broad spectrum

vegetarian enzymes that support protein, carbohydrate, fat, fiber and dairy digestion and optimal nutrient bioavailability and absorption*

• Proteases provide optimal activity

across a wide pH range, facilitating the breakdown of proteins as well as di- and tri-peptides*

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Amino-NR

Provides a natural ratio of free-form amino acids to encourage healthy neurotransmitter synthesis and support cognitive function and mood* Also includes

• Alpha lipoic acid and alpha

ketoglutarate to support mitochondrial function and energy*

• Vitamin B6 to support healthy

neurotransmitter synthesis and energy metabolism*

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

• 1. Amino acids serve as precursors for neurotransmitters
• 2. Vitamins and minerals serve as cofactors for enzymes that

synthesize neurotransmitters

1

Neurotransmitter Amino acid

Enzyme + Cofactor

2

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Neurotransmitter Synthesis

Cofactors are vitamins and minerals Facilitate the function, stability and/or activity of the enzymes and receptors responsible for neurotransmitter synthesis and response* Cofactors are commonly depleted in individuals as a result of:

• Medications
• Dietary limitations
• Environmental exposures

The Importance of Cofactors

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Key Cofactors

• Zinc
• Magnesium
• Folate
• Vitamin B6
• Vitamin B12

Neurotransmitter Cofactors

The Importance of Zinc

• Maintains the structure of the AADC

enzyme involved in the synthesis of dopamine and serotonin*

• Moderates the activity of glutamate

receptors to support both emotional wellness and long-term neuroprotection* Essential for digestion:

• Increases the activity of digestive

enzymes (see table)

• Necessary for carbonic anhydrase

activity and the formation of acid salts in the gastric mucosa

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

By supporting healthy neurotransmission zinc supports:

• Mood
• Focus
• Calmness
• Healthy eating habits

Zinc Deficiency

The Standard American Diet:

• Low in zinc rich foods
• High in foods with

components that inhibit the absorption of zinc (e.g., iron ) Other causes:

• Puberty
• Stress
• Vegetarianism
• Exercise
• Environmental toxins

Zinc: Clinical Trials

Women who took a multivitamin and zinc showed significant benefit in measurements of anger-hostility and mood1* Zinc supplemented patients had significantly improved scores for mood compared to placebo2* Patients who are refractory to other approaches were recruited to a study, in which zinc provided significant support for mood, as evident in 4 different clinical scoring methods3* Zinc supported mood, relaxation, healthy weight gain and taste recovery in patients with very low BMI, compared to placebo.4*

1. Sawada and Yokol, Eur J Clin Nutr (2010) 64(3):331-3 2. Nowak et al, Pol J Pharmacol (2003) 55:1143-1147 3. Siwek et al, J Affect Disord (2009) 118(1-3):187-95 4. Katz et al., J Adolesc Health Care (1987)

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Magnesium

• Maintains cytokine homeostasis

and antioxidant protection in the brain and nervous system*

• Inverse relationship between

serum cortisol and magnesium levels*

• Supports the calming actions of

GABA*

• Binds to the NMDA receptor,

keeping glutamate/NMDA activity within healthy limits*

GABA receptor

GABA response

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Magnesium (glycinate)

• Highly bioavailable
• Less likely to cause loose stools than
• ther forms of magnesium*
• Available in capsules or a great-tasting

liquid

• 120 mg elemental Mg per capsule
• 165 mg elemental Mg in two

teaspoons

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Folate

• A collective term referring to folic acid and its

naturally occurring analogs (mainly 5-MTHF but also 125 other different forms of folate!)

• Directly utilized by the body
• Significantly more bioavailable than folic acid

Folic Acid

• Oxidized form of folate
• Not naturally found in food
• Plays no direct role in any biochemical

reaction, must be converted to an active form

• Stability makes it preferable for food

fortification

Folate

1. Biosynthesis of neurotransmitters* 2. Myelination of neurons* 3. Regulation of gene expression (epigenetics)* 4. Amino acid metabolism* 5. Division of red blood cells* 6. Prevention of neural tube defects* 7. Reduction of homocysteine* 8. DNA replication*

8 Major Roles of Folate

SAMe

Methylation

• Neurotransmitters
• DNA
• Many other compounds

5-MTHF Homocysteine Methionine B12

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Folate and Mood

Restoring healthy dietary folate is associated with:*

• Improved mood
• Improved response to traditional approaches
• Sustainable emotional health effects
• Enhanced efficacy of other psychiatric modalities

Hundreds of studies support the relationship between folate and mood*

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Causes of Folate Deficiency

• Inadequate intake: Dietary

sources are heat labile and easily oxidized (≥ 50% lost during food storage and processing)

• Malabsorption
• Medications
• Genetic variations –

MTHFR polymorphism

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

C/T Polymorphism 56% C/C 30% T/T Polymorphism 14% Kelly CB et al. J Psychopharmacol. Bottiglieri T et al. J Neurol Neurosurg Psychiatry Surtees R, Heales S, & Bowron. Clinical Science. Lanctôt KL, et al. Brain Inj. Gilbody S, et al. Am J Epidemiol. Słopien R, et al. Maturitas. Lok A, et al. Transl Psychiatry.

Patients who have MTHFR C/T genotypes have a 1.36 times greater chance of requiring medical support for mood The odds of having the T/T genotype is twice as great in depressed patients verses the normal population

MTHFR and Mood

EA: 34% EA: 71% EA: 100% EA = Enzyme Activity

Essential Fatty Acids: EPA and DHA

EPA and DHA = omega 3 fatty acids Cognition Omega-3 fatty acids are important components of neuronal cell membranes and are essential to cognitive function* By supporting vascular health, fish oils promote oxygen and nutrient delivery to the brain.* Stress Markers Studies show that fish oil maintain healthy levels of:

• ACTH*
• Cortisol*
• Norepinephrine*
• Cytokines such as TNFα and

IFNγ*

• Maintain normal NFκB activity*
• Balance prostaglandin

production* Mood Both epidemiological and double blind placebo-controlled trials indicate that fish oil supports positive mood.*

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Pure Encapsulation’s Fish Oils

Ultra-pure, molecularly distilled fish oil concentrate Rigorously tested for:

• Heavy metals
• PCBs
• Dioxins and furans
• Microbial contaminants
• Oxidation and rancidity

EPA/DHA Essential Per capsule:

• 300 mg EPA
• 200 mg DHA

EPA/DHA Liquid Per teaspoon

• 740 – 835 mg EPA
• 460 – 550 mg DHA
• Lemon flavor

Once neurotransmitters are synthesized, their activity and stability can be influenced by specific phytochemicals*

Neurotransmitter

Degradation (inactivation) Reuptake (inactivation) Enzyme modulation*

• Taurine
• Curcuminoids
• Quercetin

Reuptake balance*

• Rhodiola rosea
• Green tea

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Regulating Neurotransmitters: Enzyme Modulation and Reuptake Balance

Serotonin: Healthy Reuptake

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

• Inositol translates serotonin receptor activation into a cellular response,

enhancing healthy sensitization to serotonin and nervous system function*

Serotonin: Healthy Receptor Activity

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

1

Comprehensive Serotonin Support*

Cofactors

• L-5-MTHF
• P5P (B6)
• Vitamin C
• Magnesium

Healthy Enzyme Activity & Reuptake*

• Taurine
• Inositol

Precursor

• 5-HTP

2 3

SeroPlu s

Supports healthy serotonin production and reuptake which promotes:

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

• Positive mood*
• Relaxation and calming*
• Moderate occasional stress*
• Healthy eating behavior*

1

Comprehensive Dopamine Support*

Cofactors

• Folate
• P5P (B6)
• Zinc

Healthy enzyme activity & Reuptake*

• Green tea leaf extract
• Rhodiola rosea

extract

• Grape seed extract

Precursor

• Tyrosine
• L-DOPA

2 3

DopaPlus

Supports dopamine production and healthy reuptake to enhance daily mental function and sharpness*

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

• Alertness*
• Cognitive function*
• Positive mood*
• Sense of reward*

NeuroPur e

1 Cofactors

• Folate
• P5P (B6)
• Zinc

Healthy enzyme activity & Reuptake*

• Curcumin
• Quercetin

Precursor

• dl-Phenylalanine
• 5-HTP

2 3 Support for mental health & emotional well-being*

Offers key nutrients to support

• verall neurotransmitter function,

neuronal health and emotional balance*

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

• Supports emotional balance and mood stability*
• Promotes the production of both serotonin and dopamine*
• Enhances phenylethylamine (PEA) activity to support mood and

alertness*

• Curcumin modulates the activity of the enzymes monoamine oxidase and

indoleamine dioxygenase (IDO) to maintain healthy serotonin levels*

• Supports optimal serum levels of zinc and folate to promote positive

mood*

NeuroPure

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

DOPAMINE

SYNAPSE

Dopamine Receptor

L-Tryptophan

SEROTONIN

Quinolinic acid

5-HTP

PRESYNAPTIC NEURON

Serotonin Receptor

L-DOPA Tyrosine

Phenylalanine

Dopamine degradation

DopaPlus NeuroPure

Serotonin Reuptake

Serotonin benefits Dopamine benefits

COM T

Glutamate Receptor

Serotonin & dopamine degradation

MA O MA O

ID O

SeroPlus NeuroPure NeuroPure

Cytokines Oxidative stress

POSTSYNAPTIC NEURON

Selecting the ideal product for your patient*

Mood support* Support for alertness* Support for relaxation* Healthy eating behavior * Cognitiv e support* General support *

DopaPlus SeroPlus NeuroPure

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

PureSynapseTM: Summary

• Proper neurotransmission is essential for healthy mood, memory,

behavior, cognition, sleep, stress and eating habits*

• Neurotransmission is dependent on the release, receptor-binding

and reuptake of neurotransmitters

• The synthesis of neurotransmitters is dependent on amino acid

precursors and vitamin/mineral cofactors

• Digestive complications, medications, dietary choices and genetic

polymorphism can lead to deficiencies in the building blocks and cofactors of neurotransmitters

• Pure Encapsulations’ PureSynapseTM offers a comprehensive line of

individual and combination products to restore neurotransmitters to healthy levels and promote normal neurotransmission*

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Visit www.PureSynapse.com

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