Nanomeshing Adds Multifunctionality to Conventional Neuroelectrodes - - PowerPoint PPT Presentation

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Nanomeshing Adds Multifunctionality to Conventional Neuroelectrodes - - PowerPoint PPT Presentation

Jan 08, 2023 894 likes •982 views

The 16 th U.S.-Korea Forum on Nanotechnology Nanomeshing Adds Multifunctionality to Conventional Neuroelectrodes Hui Fang, Ph.D. Assistant Professor, Electrical and Computer Engineering, Affiliated Faculty, Bioengineering, Mechanical &

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Nanomeshing Adds Multifunctionality to Conventional Neuroelectrodes

Hui Fang, Ph.D.

Assistant Professor, Electrical and Computer Engineering, Affiliated Faculty, Bioengineering, Mechanical & Industrial Engineering, https://www.northeastern.edu/fang/

The 16th U.S.-Korea Forum on Nanotechnology

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Biotic/abiotic interface challenges limit the scaling of microelectrode arrays (MEAs)

9/24/2019 Fang Research Group 2

1970 1980 1990 2000 2010 2020 1011 109 107 105 103 101

IEEE Trans Bio-Med Eng, 1970 IEEE Trans Rehabil Eng, 1999 Neuralink, 2019

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Correspondence problems limit the accurate decoding of brain activity

9/24/2019 Fang Research Group 3

Spatial scale (mm) Temporal scale

100 101 102 10-3 10-2 10-1 10-4 Brain Lobe Map Nucleus Layer Neuron Dendrite Synapse fMRI/PET EEG/MEG Implantable microelectrodes Patch clamp Calcium imaging Light microscopy

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Effectively bridging electrical and optical brain mapping requires transparent MEAs

9/24/2019 Fang Research Group 4

1 mm μm μm

Seo, Fang* et al., Advanced Biosystems, 2019 Qiang, Fang* et al., Science Advances, 2018

Non-penetrating

100 µm

Penetrating

Unpublished

On-µPrism

Prism

500 µm

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5 µm Nanomeshing adds transparency to conventional neuroelectrodes

9/24/2019 Fang Research Group 5

Qiang, Fang* et al, Advanced Functional Materials, 2017 Seo, Fang* et al, ACS Nano 2017

Au PEDOT:PSS

Bilayer nanomesh

nm 80 40

  • 40
  • 80

Bilayer Nanomesh Template electroplating

500nm Au NM Au/PEDOT:PSS NM 500nm

NeuroNexus 10×10 Site area (µm2) Impedance (kΩ) 10 100 1000 100×100

Performance benchmark

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Moving towards stretchable nanomesh to enable ultra- softness

9/24/2019 Fang Research Group 6

1 µm 1 3 2 4 1 3 4 2 1 µm 1 µm 1 µm

Nanomesh Ultrathin support

Seo, Fang* et al, Appl. Phys. Lett. 2018

‘There is plenty of room at the bottom’

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Technology roadmap for nanomesh µbioelectronics

9/24/2019 Fang Research Group 7

Nanomesh µBioelectronics

1 mm 500 µm 10 mm

2017 2018 2019 2020 Intelligent Multifunctional Application specific High resolution & large throughput Future

1st nanomesh microelectrode 1st bilayer nanomesh 1st wafer-scale stretchable nanomesh 1st nanomesh MEA & concurrent Ca2+ imaging 1st penetrating nanomesh MEA ACS Nano 2017

  • Adv. Fun. Mater. 2017

Applied Physics Letters 2018 Science Advances 2018 Advanced Biosystems 2019

Now

npj Flexible Electronics 2019

1 µm

1st Si nanomesh

Materials design Advanced manufacturing System integration Data handling

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9/24/2019 Fang Research Group 8

Collaborators

  • Prof. Michela Fagiolini (BCH)
  • Prof. Wentai Liu (UCLA)
  • Prof. Ralph Weissleder (MGH)
  • Prof. Claudio Vinegoni (MGH)
  • Prof. Chris Dulla (Tufts)
  • Prof. Dong Feng Chen (MEEI)
  • Prof. Shuodao Wang (OKState)
  • Prof. Ross Walker (Utah)
  • Prof. Heather Clark (NU)
  • Prof. Swastik Kar (NU)
  • Prof. Katherine Ziemer (NU)

Fang Group Members

  • Dr. Wen Gu
  • Dr. Hassan Hafeez (PhD

from Hanyang U.)

  • Dr. Zeinab Ramezani
  • Kyung Jin (KJ) Seo (from

UIUC)

  • Yi Qiang
  • Jae Hyeon Ryu (from

KIST)

  • Zhan Shi
  • Nicholas Zhang

Funding

  • NSF CAREER 1847215 (Fang)
  • NSF 1905575 (Fang, Wang)
  • NIH 1R21EY030710-01 (Fang, Walker)
  • Samsung GRO (Fang)
  • DoD W81XWH-18-1-0699 (Dulla, Fang)

Acknowledgements