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Multiple Chronic Conditions: Including people with representative comorbidities: Treating an Illness Is One Thing. What About a Patient With Many? Cynthia M. Boyd, MD MPH Associate Professor Department of Medicine and Department of


  1. Multiple Chronic Conditions: Including people with representative comorbidities: “Treating an Illness Is One Thing. What About a Patient With Many?” Cynthia M. Boyd, MD MPH Associate Professor Department of Medicine and Department of Health Policy and Management Johns Hopkins University December 2, 2015

  2. Disclosure of Interests (last 5 years) Cynthia M. Boyd, MD MPH Dr. Boyd is a co-author of a chapter on multimorbidity for UptoDate, for which she receives a royalty. She has received funding from the National Institutes of Health, Agency for Healthcare Research and Quality, the National Quality Forum and the Patient-Centered Outcomes Research Institute (PCORI) for work related to trials, systematic reviews, guidelines and people living with multiple chronic conditions.

  3. “Treating an Illness Is One Thing. What About a Patient With Many?” http://hab.hrsa.gov/livinghistory/iss ues/aging_6.htm Image: Brendan Smialowski for the New York Times, March 31, 2009

  4. It’s Not Easy Living with Multiple Chronic Conditions Time Medications Non-pharmacologic All Day Periodic Therapy 7 AM Ipratropium MDI Check feet Joint protection Pneumonia vaccine, Yearly influenza vaccine Alendronate 70mg weekly Sit upright 30 min. Energy conservation Check blood sugar All provider visits:Evaluate Self- Exercise (non-weight monitoring blood glucose, foot 8 AM Eat Breakfast 2.4gm Na, 90mm K, bearing if severe foot exam and BP Adequate Mg, ↓ cholesterol HCTZ 12.5 mg Lisinopril 40mg disease, weight & saturated fat, medical Glyburide 10 mg ECASA 81 mg bearing for Quarterly HbA1c, biannual nutrition therapy for osteoporosis) Muscle LFTs Metformin 850mg diabetes, DASH strengthening Naproxen 250mg Yearly creatinine, electrolytes, exercises, Aerobic microalbuminuria, cholesterol Omeprazole 20mg Exercise ROM Calcium + Vit D 500mg exercises Referrals: Pulmonary rehabilitation 12 PM Eat Lunch Diet as above Avoid environmental Ipratropium MDI exposures that might Physical Therapy exacerbate COPD Calcium+ Vit D 500 mg DEXA scan every 2 years Wear appropriate Yearly eye exam footwear 5 PM Eat Dinner Diet as above Medical nutrition therapy Albuterol MDI prn 7 PM Ipratropium MDI Patient Education: High-risk foot Metformin 850mg Limit Alcohol conditions, foot care, foot wear Naproxen 250mg Maintain normal Osteoarthritis Calcium 500mg body weight COPD medication and delivery Lovastatin 40mg system training Diabetes Mellitus 11 PM Ipratropium MDI Boyd et al. JAMA 2005;294:716-724

  5. How Applicable are Clinical Practice Guidelines (CPGs) for People with MCCs? • Reviewed 9 CPGs for chronic conditions • Most single disease CPGs fail to give adequate guidance for older patients with MCCs 5 Boyd et al. JAMA 2005;294:716-724

  6. Multiple Chronic Conditions is Common Percentage of Major Chronic Disease in Isolation Among Women Aged 65 or Older: NHANES, 1999-2004 Arthritis Coronary Chronic Diabetes Stroke Heart Lower Disease Respiratory Tract Disease % with only 47% 17% 19% 17% 15% 1 disease of 5 possible diseases Weiss CO et al. JAMA 2007;298:1160-1162

  7. Prevalence of Comorbidities in Adults with Coronary Heart Disease Aged ≥ 45 in NHANES, 1999 -2004 60.0 50.0 40.0 30.0 % 20.0 10.0 0.0 Diseases Clinical Factors Health Status Factors Boyd et al JAGS 2011 May;59(5):797-805

  8. Disparities in Multiple Chronic Conditions White, non Hispanic 70% 72% Black, non Hispanic 21% 14% Hispanic 6% 5% Other 2% 2% ≥ 3 77% 26% ≥ 5 41% 7% Zulman DM et al. BMJ Open 2015

  9. What Do Clinicians Need to Best Care for the People with MCCs? • Maximize use of therapies likely to benefit • Minimize use of therapies unlikely to benefit or likely to harm • An understanding of what outcomes matter most • Incorporate patient preferences and values regarding burdens, risks, and benefits

  10. Individualized Decisions Don’t Screen/treat Do Screen/treat Likelihood Likelihood of Benefit of Harm Patient Preferences (moveable fulcrum) Slide Courtesy of Louise Walter, UCSF

  11. How can we better address people with MCCs across translational path? Clinical Decision- Making Clinical Study Systematic Design and Review Practice Integrated Guideline Analysis and Meta- Care Development Analysis Performance Measurement AHRQ R21, EPC Methods, NIH CTSA, NQF via HHS, NIA JGIM Supplement, 2014. Boyd and Kent, Uhlig et al, Trikalinos et al, and Weiss et al.

  12. What comorbidities matter? • Prevalence • Important interactions – condition-condition – condition-treatment – treatment-treatment Uhlig et al JGIM April 2014

  13. Choosing Topics: Focus Comorbid Condition Morbidity/Risk Index Index Condition Condition/Risk Comorbid Comorbid Condition Condition Condition MCCs Condition Condition Uhlig et al JGIM April 2014

  14. Outcomes • Evaluating interventions requires meaningful outcomes • No standard quality metrics or outcomes to guide care for the MCC population • Minimal evidence associating recommended MCC care processes with outcomes • New interest in outcomes that reflect patient- centered constructs Slide courtesy of Elizabeth Bayliss

  15. Measuring Outcomes in People with MCCs • Deciding what outcomes matter to people – More likely to be less disease-specific • Surrogates may have a different relationship to patient-important outcomes in people with MCCs • Risks of outcomes may be different in people with MCCs • A hard look at exclusion criteria may point to what outcomes should be measured

  16. Measuring Outcomes in People with MCCs • Deciding what outcomes matter to people – More likely to be less disease-specific • Surrogates may have a different relationship to patient-important outcomes in people with MCCs • Risks of outcomes may be different in people with MCCs • A hard look at exclusion criteria may point to what outcomes should be measured

  17. In addition…. Outcomes relevant to MCCs should be: • Relevant to patients • Relevant to health care systems • Relevant to clinicians • Easy to collect, store, and extract • “Validated” – Associated with other meaningful constructs – Sensitive to change over time • Likely to be a function of the intervention

  18. Two commonly used outcomes for studies of multimorbidity • Disease-specific outcomes • Utilization – Hospital – Emergency services – Primary care – Specialty care

  19. Informing Patient-Centered Care of People with Multiple Chronic Conditions: PCORI Methods Project With our stakeholder team of investigators, - identify high-priority clinical questions and outcomes for people with MCCs, and - synthesize the evidence base to support the development of clinical practice guidelines that can better inform patient-centered care for people with multiple chronic conditions. - develop methods guidance http://www.pcori.org/research-results/2014/informing-patient-centered-care-people-multiple-chronic- conditions

  20. Example outcome domains important to complex patients • Pain • Function • Energy • Mortality • Treatment burden – Medication side effects – Lifestyle modification • Others…. C. Boyd. PCORI ME-13-0-07619

  21. Patient-reported outcomes (PROs) • Assess function and well-being (and others) • Relevant across conditions • Collection is labor intensive • Limited evidence associating PROs with clinical interventions • Systematic collection for pragmatic trials requires substantial organization and infrastructure Slide courtesy of Elizabeth Bayliss

  22. Measuring Outcomes in People with MCCs • Deciding what outcomes matter to people – More likely to be less disease-specific • Surrogates may have a different relationship to patient-important outcomes in people with MCCs • Risks of outcomes may be different in people with MCCs • A hard look at exclusion criteria may point to what outcomes should be measured

  23. Addressing Comorbidities in PICO Questions Population: Define conditions of interest Intervention and Comparators: effect modification Outcomes: choice & ranking of relevant outcomes harms, burdens, benefits non-disease specific and disease specific linkage between surrogate and clinical outcomes “ Effect of treatment on the final outcome may be small even if there are strong associations between treatment and the surrogate and between the surrogate and the patient-important outcome ” Walter SD et al 2012 Sep;65(9):940-5 Timeframe for considering outcomes : risk prediction Trikalinos et al JGIM April 2014, Uhlig et al JGIM April 2014 tradeoffs

  24. Measuring Outcomes in People with MCCs • Deciding what outcomes matter to people – More likely to be less disease-specific • Surrogates may have a different relationship to patient-important outcomes in people with MCCs • Risks of outcomes may be different in people with MCCs • A hard look at exclusion criteria may point to what outcomes should be measured

  25. Sample 1: centered, but fails to reflect the diversity of the population Sample 2: individuals who much more net benefit from the treatment than does average member of population Sample 3: broadly representative of the population in terms of risk, responsiveness, and vulnerability Kravitz RL et al. Milbank Quarterly

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