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Radiobiology Research at MedAustron – Ion Therapy and Research Centre
Sylvia Gruber, PhD Medical University of Vienna High Energy Physics Seminars Imperial College London
MedAustron Ion Therapy and Research Centre Sylvia Gruber, PhD - - PowerPoint PPT Presentation
MedAustron Ion Therapy and Research Centre Sylvia Gruber, PhD - - PowerPoint PPT Presentation
Radiobiology Research at MedAustron Ion Therapy and Research Centre Sylvia Gruber, PhD Medical University of Vienna High Energy Physics Seminars Imperial College London Contents The MedAustron Centre A Brief History
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The MedAustron Centre
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A Brief History
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Tumour Therapy Options
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Ion Beam Therapy: Physical Motivation
- Superior dose distribution
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Ion Beam Therapy: Biological Motivation
-
- Increased Effectiveness
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Ion Beam Therapy: Indications
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Facility Layout
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Pencil Beam Scanning
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Irradiation Rooms
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Irradiation Rooms – Patient Treatment
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Current Treamtents at MedAustron
Skull Base CNS Prostate Pediatric Tumours Head & Neck Sarcoma Re-Irradiation
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Irradiation Rooms - Research
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Irradiation Room 1
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Non Clinical Research Groups
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Applied and Translational Radiobiology Team
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Timeline of ATRAB at MedAustron
53BP1
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Mission
Broadening of the therapeutic index
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Focus of Radiobiological Research at MedAustron
- Challenging the RBE
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RBE Dependencies: Tissue Characteristics
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RBE Dependencies: LET
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RBE Dependencies: LET
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RBE Dependencies: Target Coverage Energy
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RBE Dependencies: Target Coverage Energy and LET
- 66.5 – 135.6 MeV
137.2 – 180.1 MeV
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Dosimetry Aspects
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Dosimetry Aspects
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Squamous Cell Carcinoma Cells
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Normal Skin Keratinocytes
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Prostate Carcinoma Cells
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A 3D World
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Advances Cell Culture Models: Multicellular Tumor Spheroids
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Advances Cell Culture Models: Multicellular Tumor Spheroids
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Therapy-relevant Factor: Hypoxia
- Indirect vs. direct DNA damage
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Spheroid Size determines Oxygen Gradient
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DNA Damage: Influence of 3D Tissue Architecture
Squamous Cell Carcinoma Spheroids
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Tumor Spheroids: Irradiation Setup
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Tumor Spheroids: Irradiation Setup
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Résumé and Workaround
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Advances Cell Culture Models: Biomimetic Epithelium
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Radiobiology of Normal Tissue Reactions
functional layer germinal layer submucosa tongue muscle
(nth gen)
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The Oral Mucositis Mouse Model
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Normal Tissue Protection: Dermatan Sulfate for OM Mitigation
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DS-mediated radioprotection: not stimulation of proliferation but junctions
2 4 6 8 10 12 14 2 4 6 8 10 12 14
days after onset of irradiation Fraction of BrdU positive cells (%) / germinal epithelial layer 2 4 6 8 10 12 14 40 60 80 100 120 140
*** ** *** * **
days after onset of irradiation Epithelial cell numbers (%)
2 4 6 8 10 12 14 50 100 150 200
days after onset of irradiation Epithelial thickness (µm)
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DS-mediated radioprotection: reduced hypoxia
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DS-mediated radioprotection: reduced inflammation
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MedAustron - Outlook
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Research Outlook– 2019-2021
- Correlation of LET and signalling events
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http://www.meduniwien.ac.at/hp/radonc/
The financial support by the Federal Ministry for Digital and Economic Affairs and the National Foundation for Research, Technology and Development is gratefully acknowledged.
Acknowledgement
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Supplementary
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Accelerator Components – Ion Sources
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Accelerator components – Low Energy Beam Transfer Line
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Accelerator components – Linear Accelerator
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Accelerator components – Synchotron
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