Mapping the Global Virome Making the Unknown Known. And the World - - PowerPoint PPT Presentation

Mapping the Global Virome Making the “Unknown Known”…. And the World Safe From a Future of Viral Threats

If you know your enemies and know yourself, you will not be imperiled in a hundred battles; …..if you do not know your enemies nor yourself, you will be imperiled in every single battle.

Sun Tzu

The Problem

Each year, approx. 3 new Viral Diseases emerge Driven by

• Population expansion (1.6 billion

in 1900 to 11.5 billion people in 2100)

• Increased encroachment into

wildlife habitat accelerates the spillover of “unknown” viruses from wildlife to humans Increasing risk from accidental and/or intentional release of “laboratory enhanced” viruses

Source: Jones et al. (2008) Nature

The threat from “novel” viruses is increasing

50 100 150 200 250 300 1945 1955 1965 1975 1985 1995 2005 2015 2025 2035 2045 2055

Actual Projected

Decades Number of EVD Events

HIV Nipah Avian Influenza SARS Zika H1N1 Ebola MERS

We e ar are e not t prep epared! ared!

The Need

We need to reimagine HOW we understand and prepare for future threats

To Move From “Reactive to Proactive”

To regard old problems from a new angle requires creative imagination.

Albert Einstein

The Opportunity

• There are approximately 1.5 million viruses circulating

in wildlife that are “unknown” – a finite universe

• We can capture and characterize the vast majority of

these viruses - turning the “unknown” into the “known”

• We have the ability to use this “knowledge” convert

the sciences of viral diseases into a big data science – being transformative and disruptive

• We can use this “information” to convert our

response to viral threats from reactive to proactive – protecting the world from future viral diseases

We Know

The Solution

The e Gl Global

• bal Virome
• me Project
• ject

The Global Virome Project (GVP) is a global partnership to transform the sciences of emerging viral diseases by:

• Developing a global database of

virtually all of the planet’s naturally-

• ccurring viral threats
• Making the world of emerging

diseases a data-rich field – driving the advanced development of countermeasures, against all future threats

GVP VP Bu Builds lds a Com

• mpre

prehensiv hensive e Vi Viral al Da Database tabase

GVP viral surveillance and collection

Genomic sequence generation Sequence database Metadata on “viral ecology” – host range, geographic distribution, epidemiology

Enabling A “Transformative and Disruptive” Public Health Tool Box Viral Atlas Database A comprehensive ecologic and genetic database on all naturally-

• ccurring viruses

Turning the Sciences

• f Emerging Viral

Disease into “Big Data” sciences

Being Transformative and Disruptive

The Approach

GVP VP: : Getting Getting to th

• the So

e Sour urce ce

Mammals and water fowl are viral reservoirs

Mammalian Habitat ranges Waterfowl breeding hotspots

GVP VP: : Mammalian mmalian Vi Virome

• me

Phase 1: 10 countries, 1,562 mammals, $366.4 M Phase 2: 16 countries, 970 mammals, $258 M Phase 3 23 countries, 447 mammals, $132.9 M

Over 10 years, will target: 68.5% of global mammalian viruses, by sampling 63.5% of global mammalian diversity, to find 71% of mammalian virome

108 Global Sampling Sites

GVP VP: : Making aking th the Un e Unkn known wn Known wnGVP

Phase 2: 21% Phase 1: 41% Phase 3: 9%

85% of Global Virome

Water fowl: 14%

The Impact

Impac act t 1: Developme elopment nt of Br Broad ad Count

• untermeasures

ermeasures

GVP

will enable the comparative analysis of thousands of members of each viral family and the advanced development of next generation countermeasures that are broadly effective – rather than against individual viruses (e.g. MERS, SARS)

MERS SARS

Converting Virology into a data-rich field

Thousands of other Corona Viruses

Universal Corona Virus Vaccine

Impac act t 2: Pan Pande demic/E mic/Epidemic pidemic Prevention ention

GVP

will enable through detailed characterization of every virus's ecologic profile – spanning host range, geographic distribution, and epidemiology – the identification of viruses that pose the greatest potential threat and the targeting of measures to prevent spillover

Minimizing the Risk of Spillover

Drive Targeted, High-Impact Risk Mitigation

• An audacious but doable visionary project
• Clear metrics and goals
• Disruptive and transformative
• Can be done in phases where each phase itself generates

useful information

• The potential to change the way we do science and engage

global health

Par Paral allel lels s to th the e Huma man n Gen enome

• me Pr

Projec ject

GVP VP Or Organ ganizational izational Par Partner tners s incl clude: ude: