Manil Chouhan Manil Chouhan Tesla is a measure of magnetic field - - PowerPoint PPT Presentation

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Manil Chouhan Manil Chouhan Tesla is a measure of magnetic field - - PowerPoint PPT Presentation

Nov 30, 2022 316 likes •811 views

Manil Chouhan Manil Chouhan Tesla is a measure of magnetic field strength The magnetic field of the earth is 0.00005 T The average fridge magnet is 0.001 T 1.5 T 3.0 T 3.0 T? Why? Why? High Resolution Head and Neck SCC Whole Body T2

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Manil Chouhan Manil Chouhan

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Tesla is a measure of magnetic field strength

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The magnetic field of the earth is 0.00005 T

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The average fridge magnet is 0.001 T

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1.5 T

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3.0 T

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3.0 T?

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Why? Why?

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High Resolution ‐ Head and Neck SCC

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Whole Body T2 ‐ Lymphoma

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Whole Body T1 ‐ Prostate Cancer

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Conventional Assessment ‐ Lymphoma MRI

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Conventional Assessment ‐ Lymphoma MRI

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Diffusion

Dynamic contrast enhancement (DCE)

Spectroscopy

Arterial spin labelling

Fat‐water quantitation

Equilibrium contrast imaging R2* imaging Blood-oxygen level dependent imaging

Susceptibility weighted imaging

Flow imaging

dynamic

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Thermal energy causes diffusion of water molecules Thermal energy causes Thermal energy causes diffusion diffusion of water molecules

  • f water molecules
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Cellular barriers cause restriction to water movement Cellular barriers cause Cellular barriers cause restriction restriction to water movement to water movement

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Diffusion ‐ Head and Neck SCC

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Diffusion ‐ Crohn’s Disease

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Post Tx

b0 b50 b200 b400

Pre Tx

b0 b50 b200 b400 Diffusion ‐ Acute Colitis

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Ktrans Ve

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DCE ‐ Prostate Cancer

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DCE ‐ Lymphoma Spleen

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Small Bowel Motility

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Vocal Cord Movement

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How? How?

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50% research 50% clinical

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Purchase and installation (50%) Underwriting of running costs on a tapering scale until grant income sufficient

‐ Senior Lectureships in Radiology and Medical Physics ‐ Research Radiographers ‐ Administation staff

3 years

CRBC funding

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Final approval summer 2010 Detailed scanner evaluation and tendering process Phillips scanner chosen Q4 2010 Installed Q1‐Q2 2011

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Research Applications Research Applications

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Pre clinical Pre clinical First in man First in man Initial Validation/ proof

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Initial Validation/ proof

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Clinical trials Clinical trials Clinical implementation Clinical implementation Novel sequences, tracers, computational techniques eg registration, motion correction. Novel therapies Novel sequences, tracers, computational techniques eg registration, motion correction. Novel therapies Pilot studies Pilot studies Single site clinical trials Single site clinical trials Multisite clinical trials‐health economics, advanced statistics, health psychology Multisite clinical trials‐health economics, advanced statistics, health psychology

Imaging

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Body imaging

Neurodegeneration Cardiovascular Disease Cellular and Gene Therapy Ear, Nose and Throat) Education, Training and Biostatistics Gastroenterology and Hepatology Infection and Inflammation cancer Neurodiagnostics NeuroImaging Neurotherapeutics Oral health Respiratory, Anaesthesia, Critical Care, and Exercise, Sports & Health Women’s Health Medical physics CABI CMIC

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Quantitative MRI for Crohn’s disease ‐ S Taylor, S Halligan, A Windsor, S Bloom Detection of vulnerable plaques in patients with acute coronary syndrome ‐ P Meier, R Botnar, A Indermuehle Neuroprotective effects of hypothermia and Xenon after perinatal brain injury ‐ N Robertson, E Cady Clinical relevance of microbleeds in stroke ‐ D Werring, R Jager, M Brown, H Houlden, T Yousry, J Hardy Postnatal brain growth and early infancy outcomes in very preterm children ‐ N Marlow, S Johnson, M de Haan, S Ourselin, N Robertson, X Golay Laryngeal Reinnervation versus Type I Thyroplasty in Unilateral Vocal Fold Paralysis Patients ‐ M Birchall, M Mat Baki, T Beale Multi-parametric prostate MRI (PROMIS) ‐ M Emberton, H Ahmed, A Kirkham, C Allen MRI for detection and characterisation of lung nodules ‐ S Punwani, S Janes, N Navani, P Shaw, M Taylor, N Bell

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MR assessment of liver haemodynamics in chronic liver disease

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The future... The future...

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UCH Cancer centre 3T MRI 3T MRI PET/MRI Basic Science Basic Science Clinical Translation Clinical Translation

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The UCLH 3T MRI team The UCLH 3T MRI team

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  • David Atkinson - Medical Physicist
  • Uma Kumar - MRI Radiographer
  • Nicola Stevens - MRI Radiographer
  • Shonit Punwani - Radiologist
  • Mara Balcombe – 3T Research Co-ordinator (not

shown)

3tresearchimagingrequests@uclh.nhs.uk

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Questions? Questions?