Looking beyond Europe: the NIDDK renal imaging workshop When : July - - PowerPoint PPT Presentation

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Looking beyond Europe: the NIDDK renal imaging workshop When : July - - PowerPoint PPT Presentation

Dec 22, 2023 193 likes •227 views

Looking beyond Europe: the NIDDK renal imaging workshop When : July 12-13, 2018 Where : Bethesda, MD, USA Organised by : Na;onal Ins;tute of Diabetes and Diges;ve and Kidney Diseases (NIDDK), NIH Objec1ves : - cover the state of the art in renal

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When: July 12-13, 2018 Where: Bethesda, MD, USA Organised by: Na;onal Ins;tute of Diabetes and Diges;ve and Kidney Diseases (NIDDK), NIH Objec1ves:

  • cover the state of the art in renal imaging and advances from other

research communi;es

  • recommend targeted research programs to op;mize and advance

research in kidney imaging (focus: spa;al and physiologic characteriza;on, GFR evalua;on, func;oning nephron number)

Looking beyond Europe: the NIDDK renal imaging workshop

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State of the art in renal func1onal imaging

  • BOLD-MRI, DWI, func;onal imaging
  • Efforts of European Consor;um in MRI (PARENCHIMA)
  • fast MR imaging of the kidneys, MR derived RBF measurements, ASL
  • emerging techniques (CEST-MRI, MR spectroscopy, sodium MRI)

Concept to clinic – cross-cu>ng issue in transla1on

  • Development and seeking regulatory approval for new contrast agents
  • Contrast Toxicity: Contrast agent safety with focus on MRI
  • How to turn an imaging technology into a biomarker: Bioinforma;cs/machine learning
  • FDA Biomarker Qualifica;on and qualified MRI Biomarkers

Industry panel

  • New MR probes to monitor ac;ve fibrogenesis
  • Magne;za;on transfer imaging (MTI)
  • Ultrasound-based elas;city for kidney transplant measurements
  • Elas;n-based molecular MRI of fibrosis

Looking beyond Europe: the NIDDK renal imaging workshop

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Talks from outside the field

  • Therapeu;c targets and the importance of imaging
  • MR Fingerprin;ng (brain)
  • Nerve calcium uptake in the brain
  • Imaging for target engagement in oncology
  • Cardiac PET

Where are we going? Toward single-nephron func1on and molecular imaging

  • Nephron number and func;on in disease
  • Ca;onized ferri;n nanopar;cles to measure renal glomerular microstructure and

func;on with MRI (nephron endowment, glomerular volume, and single nephron filtra;on)

  • Single kidney GFR by MRI in humans
  • Quan;ta;ve suscep;bility mapping

Break-out groups

Looking beyond Europe: the NIDDK renal imaging workshop