1 All digestive diseases under age 15 (2004) Ambulatory visits 1 - - PDF document

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NIDDK Support of Research in Pediatric GI, Hepatology and Nutrition Stephen P James M D Stephen P. James, M.D. Conflicts: None Director, DDDN, NIDDK jamess@extra.niddk.nih.gov Outline Burden of pediatric digestive diseases NIH

SLIDE 1

1 NIDDK Support of Research in Pediatric GI, Hepatology and Nutrition

Stephen P James M D Stephen P. James, M.D. Director, DDDN, NIDDK jamess@extra.niddk.nih.gov

Conflicts: None

Outline

Burden of pediatric digestive diseases NIH support for digestive diseases, nutrition

and obesity research

NIDDK research programs Knowledge dissemination: workshops,

education programs

Trans NIH initiatives: microbiome Future opportunities http://www2.niddk.nih.gov/AboutNIDDK/ReportsAndStrategicPlanning/

SLIDE 2

2 All digestive diseases under age 15 (2004)

Ambulatory visits 1st diagnosis

10,951,000

Ambulatory visits all diagnoses 15,170,000 Hospital discharges 1st dx

331,000

Hospital discharges all dx

2,321,000

Organization of the NIH

www.nih.gov

Research Portfolio Online Reporting Tool (RePORT)

http://report.nih.gov/rcdc/reasons/

SLIDE 3

3 NIH FY2008 Awards Budget: $29,456 million

Digestive Diseases

$1,426 million

Nutrition

1,391

Obesity

664

Diabetes

1,080

Kidney diseases

523

Urologic diseases

534

Hematologic diseases

894

Pediatrics

$2,771 million

NIDDK FY08 Budget

Training 3% R&D Contracts 9% Intramural 9% RMS 3%

RPGs 63%

SBIR/STTR 2% Centers 5% Other Research ‐ w/o Careers 2% Other Research ‐ Careers Only 4% 3%

NIDDK Grants

Research Project Grants

– R01, R03, R15, R21, R34, R37 – P01 – U01

Centers: P30, P50, U54 Small business: R41, R42, R43, R44 Other research: K’s, R13, R18, R24, R25 Training: T’s, F’s

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4 New principal investigators www.grants.nih.gov

Research consortia (U01) with pediatric relevance

Adolescent Bariatrics: Assessing Health Benefits & Risks IBD Genetics Consortium National Endoscopic Database of the Clinical Outcomes

Research Initiative

Intestinal stem cell consortium Hepatitis B Clinical Research Network Pegylated Interferon +/- Ribavirin for Children with HCV Childhood Liver Disease Research Network Nonalcoholic Steatohepatitis Clinical Research Network A Multi-Center Group to Study Acute Liver Failure in

Children

NIDDK Research Resources

NIDDK Sample repository NIDDK DNA repository NIDDK DNA repository NIDDK Data repository

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5 Clinical trial planning grant (U34)

Feng, Sandy Immunosuppression Withdrawal for Stable

Pediatric Liver Transplant Recipients

NIDDK Digestive Diseases and Obesity/Nutrition Centers

17 Digestive Diseases Centers

– Bezerra, Jorge

Di i H l h C B h B d id

– Digestive Health Center: Bench to Bedside

Research in Pediatric Digestive Disease

– Cincinnati Children’s Hospital

11 Obesity/Nutrition Centers

Training and Career Development Opportunities--NIDDK

Medical/ Grad school (Students) Postgraduate (Postdocs, fellows) Transition (Junior faculty) I ndependent I nvestigator (Faculty)

Medical students:

F30, T35, T32

Graduate students

F31, T32

Postdoctoral Research Fellows

F31, F32
T32, T35

Physician scientists

K08, K23

PhD scientists

K01, K25
K24

Research project grants

R03, R21, R01
P01, P50
U01
Contract
K99/R00

Loan Repayment Program

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6 Training and Career Development in Pediatrics

FY2008

– 10 T32 Institutional Training grants

20 K d

– 20 K awards

NIH Loan Repayment Program for Pediatric Research

http://www.lrp.nih.gov/about_the_programs/pediatric.aspx NIH FY2008: 347 awards

Loan Repayment Programs

Awards up to $35,000 per year for 2 years

towards repayment of educational loans

NIH pays the taxes on this amount directly to

the IRS

May re-compete (i.e. get 4 or even 6 years)

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7 Knowledge Dissemination

Scientific Meetings and Conferences NIH consensus conferences Education Programs Awareness Campaigns Information Clearinghouse

R13 Conference Grant Gut Microbiome, November 2008

NIH Consensus Development Conference: Management of Hepatitis B October 20-22, 2008

Chair: Michael Sorrell, MD
18 Speakers
Evaluation panel
Topics:

–

Current disease burden

–

Natural history

–

Risks/benefits of therapy

–

Who should be treated

–

How to assess therapy

–

Future research needs

NIDDK, OMAR

SLIDE 8

8 Education programs

Celiac Disease

Awareness Campaign

http://celiac.nih.gov/

National Digestive Diseases Information Clearinghouse (http://digestive.niddk.nih.gov/) Research Plans and Reports

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9 Cross cutting NIH initiatives

Human Microbiome Project (HMP) http://nihroadmap.nih.gov/hmp/

Human Microbiome Demonstration Projects involving Gut

1UH2DK083982-01 FRASER-LIGGETT, CLAIRE M (contact); SHULDINER, ALAN R. UNIVERSITY OF MARYLAND BALTIMORE The Thrifty Microbiome: The Role of the Gut Microbiota in Obesity in the Amish 1UH2DK083981-01 BUSHMAN, FREDERIC D; LEWIS, JAMES D; WU, GARY D. (contact) UNIVERSITY OF PENNSYLVANIA Diet, Genetic Factors, and the Gut Microbiome in Crohn's Disease 1UH2AI083265-01 TARR, PHILLIP I WASHINGTON UNIVERSITY The Neonatal Microbiome and Necrotizing Enterocolitis 1UH2CA140233-01 NELSON, KAREN E; PEI, ZHIHENG (contact) NEW YORK UNIVERSITY SCHOOL OF MEDICINE Foregut microbiome in development of esophageal adenocarcinoma 1UH2DK083994-01 LI, ELLEN WASHINGTON UNIVERSITY Effect of Crohn's Disease Risk Alleles on Enteric Microbiota 1UH2DK083993-01 CHANG, EUGENE B; MEYER, FOLKER ; SCHMIDT, THOMAS M.; SOGIN, MITCHELL L; TIEDJE, JAMES M.; YOUNG, VINCENT B (contact) UNIVERSITY OF MICHIGAN AT ANN ARBOR The Role of the Gut Microbiota in Ulcerative Colitis 1UH2DK083991-01 FRASER-LIGGETT, CLAIRE M UNIVERSITY OF MARYLAND BALTIMORE Metagenomic Analysis of the Structure and Function of the Human Gut Microbiota in 1UH2DK083990-01 VERSALOVIC, JAMES BAYLOR COLLEGE OF MEDICINE The Human Microbiome in Pediatric Abdominal Pain and Intestinal Inflammation

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10 American Recovery and Reinvestment Act (ARRA)

NIDDK ARRA Awards FY09

R01s, R21s Challenge Grants Revisions (competing supplements) Small business Administrative supplements

– Summer students

Examples of Challenge Grants

BUCUVALAS, JOHN C; HANCOCK, WAYNE WILLIAM (contact) CHILDREN'S HOSPITAL OF PHILADELPHIA Calcineurin Inhibitor Minimization And Foxp3+ Tregs Post-Transplant LUMENG JULIE C UNIVERSITY OF MICHIGAN AT ANN ARBOR LUMENG, JULIE C ARBOR Cortisol and Eating Behavior in Low-Income Preschool-Aged Children KATZMARZYK, PETER TODD LSU PENNINGTON BIOMEDICAL RESEARCH CTR Anthropometric Assessment of Abdominal Obesity and Health Risk in Children and Ad DEWEY, KATHRYN G UNIVERSITY OF CALIFORNIA DAVIS Prevention of Overfeeding During Infancy WHITINGTON, PETER F CHILDREN'S MEMORIAL HOSPITAL (CHICAGO) Serologic test for neonatal hemochromatosis in infants with acute liver failure KARPEN, SAUL JOSEPH BAYLOR COLLEGE OF MEDICINE Genome-Wide Analysis of RXR-alpha Binding In Mouse Liver Chromatin with ChIP-SEQ