NIDDK Support of Research in Pediatric GI, Hepatology and Nutrition Stephen P James M D Stephen P. James, M.D. Conflicts: None Director, DDDN, NIDDK jamess@extra.niddk.nih.gov Outline � Burden of pediatric digestive diseases � NIH support for digestive diseases, nutrition and obesity research � NIDDK research programs � Knowledge dissemination: workshops, education programs � Trans NIH initiatives: microbiome � Future opportunities http://www2.niddk.nih.gov/AboutNIDDK/ReportsAndStrategicPlanning/ 1
All digestive diseases under age 15 (2004) � Ambulatory visits 1 st diagnosis 10,951,000 � Ambulatory visits all diagnoses 15,170,000 � Hospital discharges 1 st dx 331,000 � Hospital discharges all dx 2,321,000 Organization of the NIH www.nih.gov Research Portfolio Online Reporting Tool (RePORT) http://report.nih.gov/rcdc/reasons/ 2
NIH FY2008 Awards Budget: $29,456 million � Digestive Diseases $1,426 million � Nutrition 1,391 � Obesity 664 � Diabetes 1,080 � Kidney diseases 523 � Urologic diseases 534 � Hematologic diseases 894 � Pediatrics $2,771 million NIDDK FY08 Budget RMS Intramural 3% 9% R&D Contracts 9% Training 3% 3% Other Research ‐ Careers Only 4% Other Research ‐ RPGs w/o Careers 2% Centers 63% 5% SBIR/STTR 2% NIDDK Grants � Research Project Grants – R01, R03, R15, R21, R34, R37 – P01 – U01 � Centers: P30, P50, U54 � Small business: R41, R42, R43, R44 � Other research: K’s, R13, R18, R24, R25 � Training: T’s, F’s 3
New principal investigators www.grants.nih.gov Research consortia (U01) with pediatric relevance � Adolescent Bariatrics: Assessing Health Benefits & Risks � IBD Genetics Consortium � National Endoscopic Database of the Clinical Outcomes Research Initiative � Intestinal stem cell consortium � Hepatitis B Clinical Research Network � Pegylated Interferon +/- Ribavirin for Children with HCV � Childhood Liver Disease Research Network � Nonalcoholic Steatohepatitis Clinical Research Network � A Multi-Center Group to Study Acute Liver Failure in Children NIDDK Research Resources � NIDDK Sample repository � NIDDK DNA repository � NIDDK DNA repository � NIDDK Data repository 4
Clinical trial planning grant (U34) � Feng, Sandy � Immunosuppression Withdrawal for Stable Pediatric Liver Transplant Recipients NIDDK Digestive Diseases and Obesity/Nutrition Centers � 17 Digestive Diseases Centers – Bezerra, Jorge – Digestive Health Center: Bench to Bedside Di i H l h C B h B d id Research in Pediatric Digestive Disease – Cincinnati Children’s Hospital � 11 Obesity/Nutrition Centers Training and Career Development Opportunities--NIDDK Medical/ Grad Postgraduate Transition I ndependent school I nvestigator (Postdocs, (Junior (Students) fellows) faculty) (Faculty) Medical students: Postdoctoral Physician •K24 Research scientists Research •F30, T35, T32 Fellows project grants •K08, K23 Graduate students •R03, R21, R01 •F31, F32 PhD scientists •P01, P50 •F31, T32 •T32, T35 •U01 •K01, K25 •Contract •K99/R00 Loan Repayment Program 5
Training and Career Development in Pediatrics � FY2008 – 10 T32 Institutional Training grants – 20 K awards 20 K d NIH Loan Repayment Program for Pediatric Research NIH FY2008: 347 awards http://www.lrp.nih.gov/about_the_programs/pediatric.aspx Loan Repayment Programs � Awards up to $35,000 per year for 2 years towards repayment of educational loans � NIH pays the taxes on this amount directly to the IRS � May re-compete (i.e. get 4 or even 6 years) 6
Knowledge Dissemination � Scientific Meetings and Conferences � NIH consensus conferences � Education Programs � Awareness Campaigns � Information Clearinghouse R13 Conference Grant Gut Microbiome, November 2008 NIH Consensus Development Conference: Management of Hepatitis B October 20-22, 2008 Chair: Michael Sorrell, MD � 18 Speakers � Evaluation panel � Topics: � Current disease burden – Natural history – Risks/benefits of therapy – Who should be treated – How to assess therapy – Future research needs – NIDDK, OMAR � 7
Education programs � Celiac Disease Awareness Campaign � http://celiac.nih.gov/ National Digestive Diseases Information Clearinghouse (http://digestive.niddk.nih.gov/) Research Plans and Reports 8
Cross cutting NIH initiatives Human Microbiome Project (HMP) http://nihroadmap.nih.gov/hmp/ Human Microbiome Demonstration Projects involving Gut UNIVERSITY OF MARYLAND 1UH2DK083982-01 FRASER-LIGGETT, CLAIRE M (contact); SHULDINER, ALAN R. BALTIMORE The Thrifty Microbiome: The Role of the Gut Microbiota in Obesity in the Amish 1UH2DK083981-01 BUSHMAN, FREDERIC D; LEWIS, JAMES D; WU, GARY D. (contact) UNIVERSITY OF PENNSYLVANIA Diet, Genetic Factors, and the Gut Microbiome in Crohn's Disease 1UH2AI083265-01 TARR, PHILLIP I WASHINGTON UNIVERSITY The Neonatal Microbiome and Necrotizing Enterocolitis NEW YORK UNIVERSITY SCHOOL OF 1UH2CA140233-01 NELSON, KAREN E; PEI, ZHIHENG (contact) MEDICINE Foregut microbiome in development of esophageal adenocarcinoma 1UH2DK083994-01 LI, ELLEN WASHINGTON UNIVERSITY Effect of Crohn's Disease Risk Alleles on Enteric Microbiota CHANG, EUGENE B; MEYER, FOLKER ; SCHMIDT, THOMAS M.; SOGIN, MITCHELL L; TIEDJE, UNIVERSITY OF MICHIGAN AT ANN 1UH2DK083993-01 JAMES M.; YOUNG, VINCENT B (contact) ARBOR The Role of the Gut Microbiota in Ulcerative Colitis UNIVERSITY OF MARYLAND 1UH2DK083991-01 FRASER-LIGGETT, CLAIRE M BALTIMORE Metagenomic Analysis of the Structure and Function of the Human Gut Microbiota in 1UH2DK083990-01 VERSALOVIC, JAMES BAYLOR COLLEGE OF MEDICINE The Human Microbiome in Pediatric Abdominal Pain and Intestinal Inflammation 9
American Recovery and Reinvestment Act (ARRA) NIDDK ARRA Awards FY09 � R01s, R21s � Challenge Grants � Revisions (competing supplements) � Small business � Administrative supplements – Summer students Examples of Challenge Grants CHILDREN'S HOSPITAL OF BUCUVALAS, JOHN C; HANCOCK, WAYNE WILLIAM (contact) PHILADELPHIA Calcineurin Inhibitor Minimization And Foxp3+ Tregs Post-Transplant UNIVERSITY OF MICHIGAN AT ANN LUMENG, JULIE C LUMENG JULIE C ARBOR ARBOR Cortisol and Eating Behavior in Low-Income Preschool-Aged Children LSU PENNINGTON BIOMEDICAL KATZMARZYK, PETER TODD RESEARCH CTR Anthropometric Assessment of Abdominal Obesity and Health Risk in Children and Ad DEWEY, KATHRYN G UNIVERSITY OF CALIFORNIA DAVIS Prevention of Overfeeding During Infancy CHILDREN'S MEMORIAL HOSPITAL WHITINGTON, PETER F (CHICAGO) Serologic test for neonatal hemochromatosis in infants with acute liver failure KARPEN, SAUL JOSEPH BAYLOR COLLEGE OF MEDICINE Genome-Wide Analysis of RXR-alpha Binding In Mouse Liver Chromatin with ChIP-SEQ 10
Future NIH opportunities � Technologies � Translation T l ti � Health Care Reform � Global Health � Reinvigorate research: funding/workforce 11
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