SLIDE 1 Eating the right foods to prevent disease
How your diet impacts DNA and gene functioning, and the link to long-term health outcomes
Assistant Professor Faculty of Land and Food Systems
LFS
Research Café
SLIDE 2 Today’s Presentation
- Chronic disease and modifiable risk factors
- Epigenetic alterations as a contributor to chronic
disease
- Impact of diet on the epigenome
- Diet as a factor shaping our health and health of
next generations
SLIDE 3
Food insecurity Chronic disease in Canada
SLIDE 4
Food insecurity Chronic disease in Canada
Direct health care costs:
$70 billion a year
+ Indirect cost:
$55 billion a year
from loss of productivity and foregone income
SLIDE 5
Food insecurity Chronic disease risk factors
SLIDE 6
Food insecurity Chronic disease modifiable risk factors Epigenetics!
SLIDE 7 Altered epigenetic patterns in chronic disease
Liver
Blue – Normal Red - Cancer
Color key and histogram
genes
SLIDE 8
Twins
SLIDE 9
Lamarck got it right
SLIDE 10 Epigenetics & gene functioning
Me Me Me Me
AcAc AcAc AcAc AcAc AcAc AcAc Condensed chromatin Open chromatin Gene silenced Gene expressed
SLIDE 11 Dynamics of epigenetic modifications
Me Me Me Me
Ac Ac Ac Ac Ac Ac Ac Ac Ac Ac Ac Ac
Viral infections Social-Economic Status Maternal care Chemicals Abusive behaviour Temperature Radiation
Diet
SLIDE 12 Recruitment
Recruitment
Nutrition & the epigenome
SAM, the methyl donor
SLIDE 13
Ctrl SAM
SAM reshapes the epigenome and protects from bone metastasis
SLIDE 14
Bioactive compounds
Disease prevention
Anthocyanins Lycopene Resveratrol Sulforaphane Organosulfides Curcumin (turmeric) Epigallocatechin Gallate Genistein Pterostilbene Quercetin Vitamin D (D3: Calcitriol) Vitamin A (ATRA)
SLIDE 15
Bioactive compounds
Disease prevention
Resveratrol Pterostilbene
SLIDE 16
Grapes and blueberries: Disease Prevention through epigenetics
SLIDE 17
Grapes and blueberries: DNA-interacting proteins responsible for epigenetic activity
SLIDE 18
Healthy cells respond to foods through changes in the epigenetic patterns
SLIDE 19
Diet and health of future generations
Epigenetics
Diet Environment Lifestyle
SLIDE 20 Predisposition of the
Epigenetic silencing of Leptin Diabetes type 2 in the offspring Gestational diabetes
SLIDE 21
Leptin as a guardian of body weight
SLIDE 22 Gestational diabetes and epigenetics
Decrease in expression through hypermethylation Inappropriately low leptin secretion for a given fat mass
SLIDE 23
Project Ice Storm Quebec 1998
SLIDE 24
Project Ice Storm Quebec 1998
SLIDE 25
Animal models to track epigenetic effects
SLIDE 26
Woah, it’s the end already. Questions? Comments?
barbara.stefanska@ubc.ca
