Kingston, Canada Queens_Canada iGEM 2011 Americas Jamboree content - - PowerPoint PPT Presentation
Kingston, Canada Queens_Canada iGEM 2011 Americas Jamboree content the problem The Challenge Our solution Approach & Methods Future Applications Accomplishments one organism. one solution. degrade report toxins target chemical
*Teng et al., 2006; UCSF 2010
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Faculty Advisors: Dr. Chin-Sang, Dr. Greer, Dr. Ko, Dr. Bendena, Dr. Ramsay, & Dr. Young. Lab Support: Tony Papanicolaou, Jeff Boudreau and rest of Chin-Sang lab. Past QGEM Team Members: Steve Goldie, Chris Palmer, Geoff Halliday, Harry Zhou and James MacLeod. QGEM 2011: Adrian McNeely, Tony He, Stephanie Zhou, Olivia Margie, Alex Campbell, Allister Smith, David Dai, Sophie Gong, Kevin Chen, Kristina Collavino, Eni Rukaj, Faisal Bakhteyar, Eszter Gereb, Gary Wu, Wei Liu, Anujan Poologaindran. QGEM 2010/2011 Executive Team
1.(Ahmed(S,(Hodgkin(J.((2000)(MRT22(checkpoint(protein(is(required(for(germline(immortality(and(telomere(replica1on(in(C.*elegans.(Nature,(403:1592164(( ( 2.(Smelick(C,(Ahmed(S.((2005)(Achieving(immortality(in(the(C.*elegans(germline.(Ageing(Research(Reviews,(4(1):67282(( ( 3.(Telomere(Shortening(and(Damage((2009)((h?p://www.immortalhumans.com/telomere2shortening2and2damage/)( ( 4.(Fire(A,(Xu(S,(Montgomery(MK,(Kostas(SA,(Driver(SE,(Mello(CC.((1998)(Potent(and(specific(gene1c(interference(by(double2stranded(RNA(in(Caenorhabdi1s( elegans.(Nature,(391(6669):806211( ( 5.(Tabara(H,(Grishok(A,(Mello(CC.((1998)(RNAi(in(C.*elegans:(soaking(in(the(genome(sequence.(Science,(282(5388):43021( ( 6.(Timmons(L,(Fire(A.((1998)(Specific(interference(by(ingested(dsRNA.(Nature,(395(6705):854( ( 7.(Timmons(L.((2006)(Construc1on(of(Plasmids(for(RNA(Interference(and(In(Vitro(Transcrip1on(of(Double2Stranded(RNA.(Methods(Mol(Biol.(351:109217.( ( 8.(Simmer(F,(Tijsterman(M,(Parrish(S,(Koushika(SP,(Nonet(ML,(Fire(A,(Ahringer(J,(Plasterk(RHA.((2002)(Loss(of(the(Puta1ve(RNA2Directed(RNA(Polymerase( RRF23(Makes(C.(elegans(Hypersensi1ve(to(RNAi.(Current(Biology,(12(15):(131721319.( ( 9.(Kiyohara(H,(Torigoe(S,(Kaida(N,(Asaki(T,(Iida,(T,(Hayashi(H(and(Takizawa(N.((1994)(Cloning(and(Characteriza1on(of(a(Chromosomal(Gene(Cluster,(pah,(That( Encodes(the(Upper(Pathway(for(Phenanthrene(and(Naphthalene(U1liza1on(by(Pseudomonas(pu1da(OUS82.(Journal(of(Bacteriology,(176:243922443.(( ( Graphics'(order(of(appearance)( h?p://s.ngm.com/2009/03/canadian2oil2sands/img/candian2oil2sands2615.jpg(( h?p://en.wikipedia.org/wiki/GPCR(( h?p://ginkgobioworks.com/support/BioBrick_Assembly_Manual.pdf( h?p://www.ncbi.nlm.nih.gov/pmc/ar1cles/PMC205370/((( h?p://www2fgg.eur.nl/ch1/cellbiology/images/jansen1.jpg((