Improved dose determination for Molecular Radiotherapy Andrew - - PowerPoint PPT Presentation

▶

Sep 10, 2023 113 likes •325 views

Improved dose determination for Molecular Radiotherapy Andrew Robinson Dave Cullen Nuclear Physics Group, The University of Manchester Jill Tipping David Hamilton The Christie NHS Foundation Trust Christie Research Huddle 07/04/14

SLIDE 1

Improved dose determination for Molecular Radiotherapy

Andrew Robinson Dave Cullen Nuclear Physics Group, The University of Manchester Jill Tipping David Hamilton The Christie NHS Foundation Trust

SLIDE 2

Christie Research Huddle – 07/04/14

SLIDE 3

Christie Research Huddle – 07/04/14

SLIDE 4

Christie Research Huddle – 07/04/14

Scatter Correction Triple Energy Window Sensitivity Factor

SLIDE 5

TRT with 177Lu-DOTATATE

EM SC RAW TEW

177Lu: t1/2

= 6.647 days bbeta (177Lu) = 100% bgamma (177Hf) = 18%

5000 MBq 300 MBq Day 0 Day 6

Christie Research Huddle – 07/04/14

SLIDE 6

Christie Research Huddle – 07/04/14

Collimator and touch plate
Crystal
PMT array
Back compartment
Shielding
Bed and mattress

Simulation - Camera

SLIDE 7

Simulation - Phantom

Christie Research Huddle – 07/04/14

SLIDE 8

Simulation - Sources

99mTc

T1/2 = 6.0 hrs Bgamma = 0.999963 (140 keV) Bbeta = 0.000037 (112 keV mean energy)

177Lu

T1/2 = 6.647 days Bgamma = 0.236 (113, 208 keV daughter nucleus) Bbeta = 1.000 (134.2 keV mean energy)

90Y

T1/2 = 64.053 hrs Bgamma = 0.000115 (1.76 MeV daughter nucleus) Bbeta = 1.000 (933 keV mean energy) Bpositron = 0.000032 (daughter nucleus)

SLIDE 9

Simulation - Sources

99mTc

T1/2 = 6.0 hrs Bgamma = 0.999963 (140 keV) Bbeta = 0.000037 (112 keV mean energy)

177Lu

T1/2 = 6.647 days Bgamma = 0.236 (113, 208 keV daughter nucleus) Bbeta = 1.000 (134.2 keV mean energy)

90Y

T1/2 = 64.053 hrs Bgamma = 0.000115 (1.76 MeV daughter nucleus) Bbeta = 1.000 (933 keV mean energy) Bpositron = 0.000032 (daughter nucleus)

SLIDE 10

Christie Research Huddle – 07/04/14

 Gate 6.1  Gate 6.2  Gate 7.0(beta)  Geant 4.9.4  Geant 4.9.5  Geant 4.9.6  Geant 4.10 (MT)

Cluster

SLIDE 11

Cluster

nucpc76.ph.man.ac.uk FASTPC2 nucpc90.ph.man.ac.uk FASTPC3 nucpc91.ph.man.ac.uk FASTPC4 nucpc96.ph.man.ac.uk FASTPC5 nucpc97.ph.man.ac.uk FASTPC6 nucpc108.ph.man.ac.uk FASTPC8 nucpc115.ph.man.ac.uk FASTPC9 x2 Xeon E5520 @ 2.27GHz 8 Cores (16 with Hyper Threading) x2 Xeon E5620 @ 2.4GHz 8 Cores (16 with Hyper Threading) x2 Xeon E5620 @ 2.4GHz 8 Cores (16 with Hyper Threading) x2 Xeon E5620 @ 2.4GHz 8 Cores (16 with Hyper Threading) x4 AMD Opteron 6176 @ 2.3GHz 48 Cores x4 AMD Opteron 6274 @ 2.2GHz 64 Cores x4 AMD Opteron 6274 @ 2.2GHz 64 Cores nucpc116.ph.man.ac.uk FASTPC10 x4 AMD Opteron 6274 @ 2.2GHz 64 Cores

264 cores 76 TB storage

SLIDE 12

Improved Scatter Correction

“Is it possible to have a scatter correction method which provides accurate quantification and improved image quality which is applicable in ALL conditions? Quantification Image Quality

SLIDE 13

Triple Energy Window Correction

ICMP 2013 – Brighton (4th September)

Infinia Hawkeye Simulation (all events) Unscattered events

SLIDE 14

Triple Energy Window Correction

K. Ogawa et al, IEEE Trans. Med.

Imaging, 10, 408-412 (1991)

Scat

EM1 EM2 Infinia Hawkeye Simulation (all events) Unscattered events

SLIDE 15

Pre reconstruction TEW Whole Image

Christie Research Huddle – 07/04/14

SLIDE 16

Pre reconstruction TEW Whole Image

Christie Research Huddle – 07/04/14

SLIDE 17

3D Printing

Use 3D printing to produce phantom inserts based on CT images.

Sensitivity Factor
Partial Volume effects
Patient specific measurements

Christie Research Huddle – 07/04/14

SLIDE 18

3D Printing

Christie Research Huddle – 07/04/14

SLIDE 19

3D Printing

Christie Research Huddle – 07/04/14

SLIDE 20