Imaging in the Era of COVID-19: Maintaining Safety Above All Dr. - - PowerPoint PPT Presentation

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Imaging in the Era of COVID-19: Maintaining Safety Above All Dr. - - PowerPoint PPT Presentation

Jan 01, 2024 567 likes •828 views

Imaging in the Era of COVID-19: Maintaining Safety Above All Dr. Rajarshi Banerjee Perspectum Ltd. Your speaker: Dr. Rajarshi Banerjee Dr. Rajarshi Banerjee is the CEO of Perspectum, he graduated in medicine from the University of Oxford

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Perspectum Ltd.

  • Dr. Rajarshi Banerjee

Imaging in the Era

  • f COVID-19:

Maintaining Safety Above All

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Perspectum Ltd.

Your speaker:

  • Dr. Rajarshi Banerjee
  • Dr. Rajarshi Banerjee is the CEO of Perspectum, he

graduated in medicine from the University of Oxford and went on to complete a Masters in Public Health at the London School of Hygiene and Tropical Medicine, before returning to Oxford, for his doctorate. He developed multiparametric liver MRI techniques at the University of Oxford, which led to the creation of

  • Perspectum. He is an expert on liver imaging and a

consultant physician for Oxford University Hospitals NHS Foundation Trust. Rajarshi has many years of experience in running clinical trials and working in multidisciplinary scientific teams to develop applications for cutting-edge imaging technology, and is a keen advocate of adaptive trial design.

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Perspectum Ltd.

Key topics to cover

Attendees are encouraged to ask questions throughout the webinar!

How the global pandemic is impacting medical research.

Prioritising safety for

  • utpatient

imaging. The impact of COVID-19 on societal well- being and healthcare. The growing importance of imaging biomarkers.

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How the global pandemic is impacting medical research

Sponsors who are actively running trials

March April May/ June

Minimize the impact on quality data collected Non-covid clinical research has been suspended in most academic settings Most large pharma companies have suspended recruitment for non-covid research This coincides with lockdown in most geographies Lock down restrictions are likely to ease in Europe When will trials resume?

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How the global pandemic is impacting medical research

Sponsors who are starting up studies

  • Find ways to work quickly. Patients

need treatments.

  • Expect increased enrolment

competition when trials resume.

  • "H

"Hey, , we do

  • what we do
  • best.

. We im improvis ise, all all rig ight?" - Brian O'Connor | Fast and Furious 6 (2013)

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Setting up a study quickly & safely.

A case study from COVERSCAN

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Study set up

30 days from initiation to first patient in

Start of study protocol drafting S u b m i t t e d t

  • t

h e R E C R E C M e e t i n g R E C I n i t i a l F e e d b a c k R e s p

  • n

s e t

  • R

E C R E C A p p r

  • v

a l F i r s t S t u d y D a y

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First Study Day

28 April 2020

AM AM AM AM

05:00 08:30 10:30 11:00 Arrival of Alliance Medical truck(s) Study Team on site at Gemini ITV Meridian First Participant

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Study Visit Flow

Maintaining safety above all Step 1 Step 2

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The Alliance Medical “Kit” Maintaining safety above all

Mobile Clinical Suite and CT Scanner Mobile MRI Scanner

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Mobile Clinical Suite & CT Scanner

Video cred Vadim Belenov

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Mobile MRI Scanner

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40 minutes scan

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Prioritising safety for outpatient imaging

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Prioritising safety for outpatient imaging

PPE: The Mask

FFP3 (European standard) respirators filter 99% of particles. FFP2 respirators are specified to filter 94% of particles

The N99 (American standard) respirator is an alternative to the FFP3 and filters

99% of particles

An N95 respirator is specified to filter 95% of particles and is a close equivalent to the FFP2 Other equivalents:

  • KN95 (China)
  • P2 (Australia/New Zealand)
  • DF FFR (Japan)

The Type IIR (European Standard) fluid resistant surgical mask is the “regular” surgical mask often used in clinical settings The Level 2 (American standard) fluid resistant surgical mask is equivalent to the Type IIR

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Participant Operator

Prioritising safety for outpatient imaging

PPE: The Mask

Type IIR/Level 2 Fluid Resistant Mask Respirator(N95 non-valved &FFP3 valved)

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Prioritising safety for outpatient imaging

Ultrasound / echocardiography

  • Ultrasound transducers and cables

should be cleaned and disinfected between patients.

  • Use only single-use gel packets.
  • Technicians should wear full PPE.
  • Clinicians who are at in

increas ased healt alth ri risk sk should not perform ultrasound procedures

  • Comordities: Over 60, obesity, hypertension,

and diabetes (Richardson et. al., 2020)

  • Cardiovasuclar disease and respiratory

system disease (Yang J et. Al., 2020)

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Prioritising safety for outpatient imaging

Ultrasound / echocardiography

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Prioritising safety for outpatient imaging

MRI/CT guidelines

2 3 4 5

Virtual patient check-in Patient in waiting room MRI/ CT Scan Deep clean the suite 15 minutes Between patients

  • Social Distancing
  • Low Patient Volume
  • Masks Provided
  • Replace fabric chairs
  • Patient and

technologist in separate rooms

  • Remote activations

available

  • Sanitize the

scanner

  • Clean coils & table
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Fatty Liver Disease is fundamental to COVID-19

The underdiagnosed, asymptomatic health condition

  • NAFLD is recognized as the most

prevalent chronic liver disease globally, with a well documented association with

  • besity and metabolic syndrome.
  • Obesity is the biggest single chronic risk

factor for hospital admission for COVID- 19 in patients under 60, in increas asin ing the ri risk sk 2-3-fo fold.

  • Identifying high-risk patients and

assessing multi-organ involvement is vital.

  • NASH awareness may increase as a result

"Understanding the impact of COVID-19 on specific patient populations such as those with obesity, diabetes, fatty liver disease and NASH is essential to providing actionable advice to clinicians and patients to provide optimal care and avoid needless deaths.”

  • Donna Cryer, President of the Global Liver Institute
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The impact of COVID-19 on societal well-being and healthcare

  • Best time to invest in healthcare tech is now!
  • Second chance at missed opportunities.
  • Eli Lilly’s CEO David Ricks said the biopharma industry has

a “o “once in a generation opportunity to reset" its reputation.

  • Gilead CEO Daniel O’Day believes the pandemic will help

for “innovative, research-based companies,”

  • The public will recognize the industry’s “ability to solve a human

crisis like this, because of the decades of investment,” he said. “T “The tone is different in Washington."

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How will COVID-19 affect future endpoints?

The growing importance of imaging biomarkers

COVID-19 has highlighted the importance of non-contact, non-invasive testing Prior authorization for NASH will be imaging and bloods Biopsy is inherently more invasive

Now more than ever, it’s important to have a way to diagnose NAFLD/NASH patients due to the underlying comorbidities associated with COVID-19.

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Questions & Answers

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Thank you

To find out more visit: Perspectum.com To find out more information:

Thank you

Perspectum.com @PerspectumGroup @perspectum.diagnostics