Hodgkin-Huxley model simulator Katrin Valdson Kristiina Pokk - - PowerPoint PPT Presentation

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Dec 27, 2023 594 likes •682 views

Hodgkin-Huxley model simulator Katrin Valdson Kristiina Pokk Marit Asula Tartu 2015 Introduction I = g(V E )+ gn (V E)+ g mh(V E ) Simulator Simulator Topics of the simulator exercises Part I:

SLIDE 1

Hodgkin-Huxley model simulator

Katrin Valdson Kristiina Pokk Marit Asula

Tartu 2015

SLIDE 2

Introduction

I฀ = g฀(V − E฀ )+ g฀n⁴(V − E฀)+ g฀ₐm³h(V − E฀ₐ)

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Simulator

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Simulator

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Topics of the simulator exercises

Part I: Equilibrium Potential Part II: Membrane Potential Part III: The Action Potential Part IV: The Fast Sodium Channel Part V: The Delayed Rectifier Part VI: Voltage-Gated Channel Parameters

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TTX

neurotoxin
found in pufferfish, octupuses,

marine worms, amphibians

deadly in very small amounts
blocks Na ion channels
prevents action potential from

happening

SLIDE 7

TEA

Tetraethylammonium
found in simple salts
used in pharmacological research
blocks K ion channels
prolonged action potential

SLIDE 8

Pronase

group of proteolytic enzymes
extracellular fluid of a species

bacteria in soil

blocks only the Na inactivation gate
results in prolonged action potential