Healthy Aims Overview Healthy Aims Project IST-2002-1-001837 . - - PowerPoint PPT Presentation

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Oct 18, 2022 344 likes •657 views

Healthy Aims Overview Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk The Healthy Aims IST Project 25 EU partners will develop a range of medical implants

SLIDE 1

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Healthy Aims Overview

SLIDE 2

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

The Healthy Aims IST Project

25 EU partners will develop a range of medical

implants including: Retina implant Cochlear implant FES system for lower and upper limbs Sphincter sensor Glaucoma sensor Pressure sensor for brain cavity and aorta

SLIDE 3

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Glaucoma Sensor Retina Implant Cochlear Implant Sphincter sensor Intracranial Pressure Sensor IMU for Human Body Motion Functional Electrical Stimulation Gyro Accelerometer

SLIDE 4

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

The medical devices will utilise these technologies

Implantable energy source (conventional and fuel cell). Body Area Network to communicate from in or on the body to base station up to 3m away. Micro-electrodes on non Silicon substrates. Micro-assembly methods for true 3D systems. Biomaterials suitable for interfacing devices in the body.

SLIDE 5

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

RF Comms Biomaterials Biofuel Cells

RF PCB

RF Data Link 403 MHz

Base station

3 meters max.

Application Chip

Battery

Base Station Data Interface Wake-Up RF Circuit RF Chip MACMICS RF Wake-Up

Sensor or control with MICS & antenna

MICS RF MAC

Wake-Up Link

Fouling on electrode surface blocking conductivity to nerves Neurite growth on surfaces

Micro-connectors Micro-electrodes and nano- electronics

Encrustation forming on foreign bodies

SLIDE 6

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

The exploitation requires

Medical devices manufacturers Medical Systems suppliers Medical Approvals bodies Surgeons and clinical teams from hospitals Medical Service providers e.g Social Services Local medical practices Purchasing teams, e.g NHS in the UK Medical Insurance groups

SLIDE 7

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

The Healthy Aims Team

Research Groups in micro and nano technology
Biomaterials experts
RF communications experts
Power sources experts
Design teams
Medical Device manufacturers
Surgeons and clinical teams, including ethics

These all came from the NEXUS Medical Devices USC and includes 6 SMEs from across the EU.

SLIDE 8

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Wireless communications

Specifically to meet the following specification MICS compatible (402 – 405 MHz / 433MHz) Downlink 250 Kbit/s, Uplink 500Kbit/s Power output limited to 25µW EIRP Range 1.5 – 3.0 metres Housekeeping software

SLIDE 9

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

System Overview

SLIDE 10

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Micro scale electrodes

Processes can provide both high density electrodes and “first level” interconnections. Electrode tips can be formed in 3D. Interaction with the biomaterials work package will define electrode shapes for improved electrode–tissue interaction

SLIDE 11

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Packaging & Assembly

Materials Materials Micromachining Micromachining I nterconnect I nterconnect Encapsulation and Encapsulation and Protection Protection Assembly and Verification Assembly and Verification

SLIDE 12

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Cochlear implant, CTC Overall connector design

microTEC dummy connector attached to electrode by CTC

SLIDE 13

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Biomolecular surface modification can be used to

rganise cell growth.
Micro contact printing of collagen on glass substrate.

Cells

PDMS Silicon

Scale bar 100 µm

SLIDE 14

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Battery Cell Design

R.Gardette/CEA

SLIDE 15

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

WHAT I S A BI OFUEL CELL

SLIDE 16

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

IMIT 3-axis Gyro Progress

Evaluation of the ASIC for high integration level

Evaluation board Single axis sensor Detail of the MEMS structure

In cooperation with Melexis (B) and XFab (D)

SLIDE 17

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Accelerometer Progress

SLIDE 18

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Human body motion - Salford

SLIDE 19

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Application of IMU in the project

The primary application area in HA is in

Advanced Functional Stimulation

All current systems are controlled using

basic switches or FSRs, which severely limit their usability

HA will demonstrate the use of the IMU

as the sensor system in the control of an advanced implantable Functional Stimulation System.

SLIDE 20

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Cochlear Implant

Present commercial product

SLIDE 21

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Glaucoma Sensor - Wired sensor

SLIDE 22

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Glaucoma sensor - Trials with first version

Trials with first version of wired lens:

Trials at Fribourg Cantonal Hospital
Only sane patients tested
Protocol did not allow to modify the IOP during trials

Protocol:

Lens traceability & patient information
Anesthesia with oxybuprocain
IOP measurement on both eyes with Goldman and TonoPen, Biometry of the eye.
Placing the lens on the eye done by MD

1) Open eye : 3 positions (sitting / lying / standing) & Valsalva maneuver 2) Closed eye: 3 positions & Valsalva maneuver

Measurements with TonoPen on second eye at every step in the protocol.
Feedback from patient at the end of session

SLIDE 23

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Our Approach – The Learning Retina Implant

Glasses + Camera Chip (integrated) Pocket Processor Retina Implant Visual Cortex

SLIDE 24

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Upper Limb Implant

Mixed monopolar electrodes
Common anode
Choose up to 6 from 9

stimulation points

SLIDE 25

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Sphincter sensor Progress

SLIDE 26

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Intracranial Pressure Sensor Prototype

Telemetry unit Conducting lead Measuring head External reader/ writer device

SLIDE 27

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Intracranial Pressure Sensor

Application: ICP

Hydrocephalus describes state
f excessive accumulation of

CSF within the fluid system of the head causing high intracranial pressure

Therapy: draining CSF from

the CNS by shunts

– Shunt failure

Approx 40 per 100,000

Individuals have shunts in place

– 125,000 p.a. in USA

www.motiv-medtech.com

SLIDE 28

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Applications: EVAR (2)

Endoleak development can

lead to pressurization and increased risk of rupture

– Continuous surveillance required

Standards of clinical

surveillance

– Contrast media enhanced CT scanning – MRI – Pressure measurement via percutaneous puncture

S ccess of therap

L. A. S

anchez et al. in J Vasc S urg, 26,2; 1997

SLIDE 29

Healthy Aims Project IST-2002-1-001837 . European Technology for Business Ltd, T: +44 1438 822822, F: +44 1438 822811, www.etb.co.uk

Summary at 18 months in Healthy Aims

Technology development driven by medical

applications.

Number of technical and commercial issues.
Call for new partners started in Month 17 for:

– Commercial partner for intra-cranial pressure sensor system – FES applications – Mobile communications.

Copies available on www.healthyaims.org