Applying micro- and nanotechnologies in the health sector: - - PowerPoint PPT Presentation

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Applying micro- and nanotechnologies in the health sector: - - PowerPoint PPT Presentation

Feb 26, 2024 656 likes •822 views

European Technology for Business Ltd Applying micro- and nanotechnologies in the health sector: Opportunities and barriers Denis Hodgins Operations Director ETB ETB Ltd, Codicote Innovation Centre, St Albans Road, Codicote Herts, SG4 8WH

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European Technology for Business Ltd

ETB Ltd, Codicote Innovation Centre, St Albans Road, Codicote Herts, SG4 8WH www.etb.co.uk Phone 01438 822822 Fax 01438 822811 email info@etb.co.uk

Applying micro- and nanotechnologies in the health sector: Opportunities and barriers Denis Hodgins Operations Director ETB

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European Technology for Business Ltd

ETB Ltd, Codicote Innovation Centre, St Albans Road, Codicote Herts, SG4 8WH www.etb.co.uk Phone 01438 822822 Fax 01438 822811 email info@etb.co.uk

Why is MNT needed in the medical field?

  • The body comprises a

number of small

  • rifices, flexible tubes
  • Bacteria often causes

growth on foreign bodies, so size should be minimised and biocompatible coatings are essential

small crystals, 100-200 µm long growing in a valve

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European Technology for Business Ltd

ETB Ltd, Codicote Innovation Centre, St Albans Road, Codicote Herts, SG4 8WH www.etb.co.uk Phone 01438 822822 Fax 01438 822811 email info@etb.co.uk

Example from Healthy Aims - Glaucoma sensor using MNT

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SLIDE 4

European Technology for Business Ltd

ETB Ltd, Codicote Innovation Centre, St Albans Road, Codicote Herts, SG4 8WH www.etb.co.uk Phone 01438 822822 Fax 01438 822811 email info@etb.co.uk

  • Silicon based
  • Direct insertion, no

stylet needed

  • Dense electrode array
  • Potential to integrate

active devices

– Force sensor – Multiplex addressing

Example from Healthy Aims - Modiolus electrode from ITE

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SLIDE 5

European Technology for Business Ltd

ETB Ltd, Codicote Innovation Centre, St Albans Road, Codicote Herts, SG4 8WH www.etb.co.uk Phone 01438 822822 Fax 01438 822811 email info@etb.co.uk

Example from Healthy Aims – Electrodes for retina implant

  • In this application the

electrode structure is very thin (10µm)

  • The electrode tips are

formed as truncated pyramids, spacing around 200µm

  • This improves the

contact to the tissue

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European Technology for Business Ltd

ETB Ltd, Codicote Innovation Centre, St Albans Road, Codicote Herts, SG4 8WH www.etb.co.uk Phone 01438 822822 Fax 01438 822811 email info@etb.co.uk

Example from Healthy Aims – Human body motion using inertial systems

Wireless 3-axis accelerometer Reach and grasp trials for FES trigger Detecting balance

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SLIDE 7

European Technology for Business Ltd

ETB Ltd, Codicote Innovation Centre, St Albans Road, Codicote Herts, SG4 8WH www.etb.co.uk Phone 01438 822822 Fax 01438 822811 email info@etb.co.uk

Example from Healthy Aims – Human body motion

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SLIDE 8

European Technology for Business Ltd

ETB Ltd, Codicote Innovation Centre, St Albans Road, Codicote Herts, SG4 8WH www.etb.co.uk Phone 01438 822822 Fax 01438 822811 email info@etb.co.uk

Assembly, Packaging and encapsulation

  • Any medical device requires:

– Assembly, where size and shape of the components is critical for the final application – Packaging, where the application defines the overall space envelope – Encapsulation, where the application defines the level

  • f biocompatibility required. Implants have the most

stringent requirements.

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SLIDE 9

European Technology for Business Ltd

ETB Ltd, Codicote Innovation Centre, St Albans Road, Codicote Herts, SG4 8WH www.etb.co.uk Phone 01438 822822 Fax 01438 822811 email info@etb.co.uk

Medical devices utilise a range of technologies

These include: MST/ MNT sensors Electronic components – some active, some passive. Implantable energy source. Body Area Network to communicate from in or on the body to base station up to 3m away. Micro-electrodes interfacing to the implantable electronics on non Silicon substrates. Biomaterials

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SLIDE 10

European Technology for Business Ltd

ETB Ltd, Codicote Innovation Centre, St Albans Road, Codicote Herts, SG4 8WH www.etb.co.uk Phone 01438 822822 Fax 01438 822811 email info@etb.co.uk

Exploitation of Medical products requires:

Medical devices manufacturers Medical Systems suppliers Medical Approvals bodies Surgeons and clinical teams from hospitals Medical Service providers e.g Social Services Local medical practices Purchasing teams, e.g NHS in the UK Medical Insurance groups So make sure these are involved early on in the development programme.

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SLIDE 11

European Technology for Business Ltd

ETB Ltd, Codicote Innovation Centre, St Albans Road, Codicote Herts, SG4 8WH www.etb.co.uk Phone 01438 822822 Fax 01438 822811 email info@etb.co.uk

The barriers for medical devices

Before any medical product can be brought to market it must have undergone clinical trials, which requires ethics approval and subsequently CE marking. Medical teams need to work with the R&D groups and

  • manufacturers. All work must be fully documented.

Clinical efficacy may take years and require a number of clinical teams to trial the system. Typical time to market for an implant is 10 years from initial concept. Cost for medical trials, including insurance is high.

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European Technology for Business Ltd

ETB Ltd, Codicote Innovation Centre, St Albans Road, Codicote Herts, SG4 8WH www.etb.co.uk Phone 01438 822822 Fax 01438 822811 email info@etb.co.uk

Types of Partners required for future MNT based medical projects

  • Research Groups in micro and nano technology
  • Biomaterials experts
  • RF communications experts
  • Power sources experts
  • Design teams
  • Medical Device manufacturers
  • Surgeons and clinical teams, including ethics
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European Technology for Business Ltd

ETB Ltd, Codicote Innovation Centre, St Albans Road, Codicote Herts, SG4 8WH www.etb.co.uk Phone 01438 822822 Fax 01438 822811 email info@etb.co.uk

End 2006 End 2008 End 2010 End 2012

Power system for external trigger developed for medical applications Develop implant systems - stand alone, intelligence in large external unit. Expensive niche markets Biomaterials for coatings developed (nano) Micro-electrodes/cables developed to reduce size Sensors developed for external triggering

FES with macro external unit eye, ear shoulder, arm

Develop Biomaterials for sensors,actuators I n t e l l i g e n c e i n t e g r a t e d i n t

  • i

n t e r n a l m

  • d

u l e , c u s t

  • m

s p e c i f i c s i g n a l p r

  • c

e s s i n g

FES with external unit for eye, ear fingers, toes Implants with no external trigger and minimal or no external unit

Reduce power source size, but remain external D e v e l

  • p

m i n i a t u r e s y s t e m s w i t h n e w t r i g g e r m e c h a n i s m s M i c r

  • e

l e c t r

  • n

i c s f

  • r

n e r v e d e t e c t i

  • n

d e v e l

  • p

e d ( b r a i n

  • r
  • t

h e r p a r t s

  • f

t h e b

  • d

y ) New MST internal power system for long term implant New internal sensor developed

Improved functionalit y for active implants produced e.g. heart pacemaker Implants to monitor functions Active implants with only the electrodes and active sensors internally Call for treatment/ alarm trigger system Remote controlled implants

New micro pumps/valves developed I m p l a n t d e v e l

  • p

e d i n p a r a l l e l w i t h s e n s

  • r

s a n d a c t u a t

  • r

s Sensors developed for internal use (e.g. accelerometer, gyro, pressure sensor) D e v e l

  • p

i m p l a n t t

  • w
  • r

k w i t h a l t e r n a t i v e p

  • w

e r / d a t a c

  • u

p l i n g m e t h

  • d

s D a t a / p

  • w

e r c

  • u

p l i n g m e t h

  • d

s d e v e l

  • p

e d t

  • e

l i m i n a t e t h e n e e d

  • f

c a b l e s a n d r e c e i v e r Develop external communication to implants (e.g. RF blue tooth) + links to hospitals/doctors/treatment providers

ROADMAP FOR IMPLANTS AND STIMULATORS 2007 FES, with external systems 2010 FES, with no external systems 2008 Active implants 2007 Monitoring implants 2010 Alarm treatment system 2012 Remote controlled system

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European Technology for Business Ltd

ETB Ltd, Codicote Innovation Centre, St Albans Road, Codicote Herts, SG4 8WH www.etb.co.uk Phone 01438 822822 Fax 01438 822811 email info@etb.co.uk

Summary

  • All intelligent medical systems integrate MNT with a

variety of other technologies.

  • Technology development is driven by medical

applications.

  • Number of technical issues relating specifically to the

application, can only be resolved when working closely with clinical experts.

  • Commercial aspects needs to be considered from the
  • utset of any new medical product development.
  • Examples from the Healthy Aims project detailed on

www.healthyaims.org