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SIXTH FRAMEWORK PROGRAMME
Information Society
Technologies
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Healthy Aims A successful FP6 project Presented at the European - - PowerPoint PPT Presentation
Healthy Aims A successful FP6 project Presented at the European - - PowerPoint PPT Presentation
Healthy Aims A successful FP6 project Presented at the European Funding for Life Sciences FP7 event on 20 th February 2007 by: Dr Diana Hodgins Project Co-ordinator Healthy Aims Managing Director European Technology for Business Ltd
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The development and subsequent exploitation
- f new products requires:
Research groups Designers Manufacturers End users
The benefit from ICT research will be realised when it is exploited in new products
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Where ICT fits in the Supply Chain
Smart Systems Integration New ICT Based System ICT Technology Development
Define building blocks Develop system with manufacturers and services Work with end users to exploit new system Ascertain which technologies are required Agree system solution with manufacturers and end users Learn requirements from end users
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How roadmaps can be used
Roadmap defines the systems to be developed. Development of technologies to achieve the systems are defined with timescales. The integration of technologies is clearly specified. All stakeholders, including end users and services are involved in the development of the roadmap, and agree the
- verall objectives .
Example shows the NEXUS roadmap for Medical Implants
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NEXUS Device Roadmap for Medical Implants
2002 2004 2006 2008 2010
2 monitoring implants 3 Active implants e.g. pacemaker 5 Active implants: electrodes/ sensors intern. 8 Remote controlled implants 1 FES with external systems MST sensors for external trigger MST power syst. for ext. trigger Miniaturized µ-electrodes/ cables Biomaterials for coatings 4 FES with external unit Systems with µ-trigger Reduced size power syst. Biomaterials for sensors External communication (e.g. Blue Tooth) + links to hospitals/treatment providers 7 Call for Treatment/ alarm trigg. Wireless data/power coupling MST sensors for int. use e.g. gyro, acceler., pressure 6 FES with no ex- ternal unit new power/data coupling meth. New MST µ-pumps/valves Implant development Wireless data/power transm. µ-electronics for nerve detection New MST internal sensor Internal signal processing Power syst. for long term impl.
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Planning a new ‘Integrated Project’
Core group agree the outline concept, the ‘VISION’ Agree the project co-ordinator. Have a call for partners. Chose a Steering Committee who then chose the consortium. Detail the project aims, and agree with all partners. Plan the proposal preparation as a project, and agree how it will be funded. Agree the plan with all partners, and follow it.
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The Consortium
Needs to be complementary, avoid overlap. The complete Supply chain MUST be present, no gaps. The partners should be world class in their field, and must fit the project. Whilst it needs EU partners, don’t focus on bringing in particular countries, unless they fit the consortium requirements.
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The Healthy Aims Consortium
Research Groups in micro and nano technology Biomaterials experts RF communications experts Power sources experts Design teams Medical Device manufacturers Surgeons and clinical teams, including ethics Partners came from the NEXUS Medical Devices USC and include 6 SMEs from across the EU.
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Healthy Aims partners
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‘Healthy Aims’ Goals
Healthy Aims is an EU FP6 project with the goal to develop a number of intelligent medical implants and diagnostic systems, integrating a range of underpinning micro- and nano- technologies. The medical products undergoing patient trials within the Healthy Aims project provide a benchmark of today’s state-
- f-the-art worldwide.
There are six clinical partners in the project, to help develop the system specifications, guide the development work and carry out clinical trials on prototypes.
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Products being developed within Healthy Aims
Intra-cranial pressure sensor Cochlear implant Bladder and bowel electrical stimulators Sphincter sensor Retina implant Electrical stimulation (FES) for limb motion
telemetry chip passive gauge antenna active gauge
Glaucoma sensor Activity monitor
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Functional Electrical Stimulation (FES)
Epineurium Electrode pair placed close to the nerve Evoked Action Potentials Electromagnetic field 1mm
Motion Sensor Motion Sensor Implant Controller
Sensor system used to determine when the implant should be triggered Wireless communication sends signal to trigger the implant Implanted, encapsulated electronics generate the electric pulse Electric pulse passed into the electrodes which excites the nerve Nerve causes muscle movement in the arm
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MNT developments within Healthy Aims
Examples of electrode developments within Healthy Aims that have been applied to the different implants:
Sphincter Sensor Glaucoma Sensor Strain gauge Cochlear Implant – Modiolus electrode Retina Implant - 3D electrodes 3-axis gyro
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Micro-packaging developments
3D flexible packaging including ASIC thinning down to 50µm and flip chip bonding is one of the successes from the project so far, which is applicable to a range of products:
active gauge
Ref sensor IC Antenna Active sensor
- Glaucoma Sensor
- Retina Implant
- Cochlear Implant
- ICP sensor
Glaucoma sensor
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Communications from in the body
The implant transmitters must have a wireless method for transmitting data to external receivers. The data transfer method is defined by the specific application and in some applications includes power transmission. On the body communication use Bluetooth or Zigbee
13.56 MHz 5 MHz 403 MHz (MICS) IR 27.3 MHz Carrier freq for data ICP sensor Cochlear implant Electrical Stimulation Retina implant Glaucoma sensor Product
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MICS - Communicating data through the body
Losses through the body are an important consideration when designing a new system. The diagram shows the energy loss for the MICS system. The antenna design is critical to the performance.
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Encapsulating Biomaterials and functional interface between electrodes and nerves
- Means of improving the
connection between the electrode and the nerve cells to optimise charge transfer.
- Biocompatible encapsulating
materials to stop water ingress into the implant and prevent leeching of materials from the implant into the body.
Aligning electrically active neurons to the electrode surface Preventing adhesion of non electrically active cells. Silicone rubber Silicone rubber coated with diamond-like carbon (DLC)
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Implantable Rechargeable Battery
Implantable power source for the Cochlear & FES systems First prototypes available
Average current Minimum voltage Dimensions Life time 4000
- No. of charges
Specification Parameter 5mA Average current 3V Minimum voltage 5 x 10 x 22 mm Dimensions 10 years Life time 4000
- No. of charges
Specification Parameter
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Biofuel cell to meet future implant challenges
A biofuel cell requires no charging - hence ideal for implant applications. Suitable for low power implants, like a pacemaker.
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Some Examples of results at end Year 3
Retina implant ICP Sensor and 3D packaging Electrical stimulator for hand and wrist control Activity monitor Sphincter sensor
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FP7 – The way forward
Many Healthy Aims partners are keen to pursue their work in FP7. Some of the examples provided indicate where nanotechnology could be applied to enhance the existing state-of-the-art. Health is a key topic in FP7 and so the potential for a project integrating nanotechnology into medical applications is high.
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Examples of EU citizens we could help
Northern Neonatal Network
Elderly at risk Babies at risk Stroke patients Healthy athletes
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Future FP7 Integrated Projects in MNT
Integrated Projects (IPs) enable complete systems to be realised effectively. The complete Supply chain needs to be present in any system development, and SMEs are an integral and essential part of these. Other technologies need to be integrated with MNT, e.g Biomaterials, wireless comms, in order to produce complete systems. The goals must be agreed from the outset, and this can be achieved using Roadmaps.
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Challenges still facing the clinical research community
The focus of future clinical research activities could aim for:
– the performance of implantable prostheses to be closer to that
- f the human,
– implantable in babies, – Lifetime means from 75+ years.
Medical manufacturers and clinical experts are an essential part of these new development projects to ensure that they meet the clinical need, can be implanted by surgeons and can be manufactured.
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– increase the density of individually addressable electrode arrays. – provide implantable energy sources that last a lifetime. – investigate alternative stimulation locations. – develop alternative methods of providing data communications through the body. – develop new sensors and embedded software solutions that enable new implants and diagnostic systems to function without any input from the user/ patient.
MNT research activities could focus on key areas
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