Achievements 2006-2010 FP6 period EuResist Integrated DataBase - - PowerPoint PPT Presentation

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Achievements 2006-2010 FP6 period EuResist Integrated DataBase EuResist predictive engine Publications/workshops Post FP6 period - 2010 Not-profit organisation (GEIE) Inclusion of data from new scientific partners Data

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Achievements 2006-2010

FP6 period

EuResist Integrated DataBase
EuResist predictive engine
Publications/workshops

Post FP6 period - 2010

Not-profit organisation (GEIE)
Inclusion of data from new scientific partners
Data transfer to a substantial number of third parties
Publications/workshops/scientific meetings
Translation into Russian
Update of the EIDB and the EuResist predictive engine, Nov 2010
Prediction of response without genotypic resistance data

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New EuResist Network web site www.euresist.org

Private area: usual functions (blackboard, documents storage etc) plus WIKI for collaborative document writing Links to main EuResist tools

EuResist Prediction engine: www.engine.euresist.org
EuResist Satellite DB: www.satellite.euresist.org
EuResist for CHAIN:

http://www.euresist.org/web/guest/chain

Achievements/planned activities from 2011 and onwards

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Improved data catchment

EuResist Satellite DB
InfCare HIV

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International activities

ENEAA EDCTP project

– Kenya, Tanzania, Ethiopia

PLANTA project

– Central America

Other affiliated projects

– DOTARV: Vietnam – HIVIND: India – Eastern promises: Russia (n=3)

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ENEAA EDCTP

EDCTP networking action "Integrated training activities and IT

infrastructures to improve capacities in eastern African area«

Objective: to strengthen the capacities of the involved partners and

countries to deal with the emerging issue of resistance to anti-HIV drugs. – To upgrade lab infrastructure; – To upgrade IT infrastructure; – To train people at the involved sites; – To merge the data into the EuResist Integrated DB (EIDB) and realise a resistance prediction engine able to support doctors in (East) Africa, based on the specific (East) African situation.

Partners are: Karolinska Institute, Area Vasta Toscana (M. Toti - M.

Zazzi), Muhimbili Hospital (Tanzania – F. Mugusi – M. Bakari), Addis Ababa Univ. (Ethiopia, D Fekade – A Wonderwossen), Worlds friends Onlus - Neema Mamy Hospital (Kenya, G. F. Morino – N. Washington – M. Mwau), and EuResist as subcontractor and co- financing.

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PLANTA

The "Pediatric Latino-American Network for Treatment of Aids“ is

developing a web based storage and analysis system of data of children with HIV/AIDS, common to all countries in Central America

Started in July 2010, PLANTA is based on intergovermental

agreement of all the involved countries

PLANTA is funded by the Italian Cooperation for Development,

under the direction of the Italian Latin American Institut (IILA) and in partnership with the Paediatric European Network for the treatment

f AIDS (PENTA).
Coordinated by G. Donia (IILA) and G. Castelli Gattinara for the

scientific side (Osp. Pediatrico Bambino Gesù – Planta) it involves: COSTA RICA, EL SALVADOR, GUATEMALA, HONDURAS, NICARAGUA, PANAMA

INFORMA is technical partner

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2011- onwards

Include new anti-HIV drugs
Evaluate the potential use of HIV predictive engines in the

regulatory situation (European Medicines Agency)

Involve new international partners and expand the database
Knowledge transfer, capacity building
Prediction of drug combination without resistance

sequences

Prediction in therapy naive individuals
Hepatitis