Flourine-18 Production Using High Intensity Laser-Induced Protons 1 - - PowerPoint PPT Presentation

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Flourine-18 Production Using High Intensity Laser-Induced Protons 1 - - PowerPoint PPT Presentation

Feb 09, 2023 206 likes •366 views

Flourine-18 Production Using High Intensity Laser-Induced Protons 1 , K.W.D Ledingham 3 , P. McKenna 3 , T. McCanny 3 , J M Gillies* 1 , K.W.D Ledingham 3 , P. McKenna 3 , T. McCanny 3 , J M Gillies* S. Shimizu 3 3 , J. Yang , J. Yang 3 3 , L.

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SLIDE 1

Flourine-18 Production Using High Intensity Laser-Induced Protons

J M Gillies* J M Gillies*1

1, K.W.D Ledingham

, K.W.D Ledingham3

3, P. McKenna

, P. McKenna3

3, T. McCanny

, T. McCanny3

3,

,

  • S. Shimizu
  • S. Shimizu3

3, J. Yang

, J. Yang3

3, L. Robson

, L. Robson3

3, J. Bailey

, J. Bailey2

2, G.N. Chimon

, G.N. Chimon1,2

1,2,

, R.J.Clarke R.J.Clarke4

4, P.A. Norreys

, P.A. Norreys4

4,

,

  • J. Zweit
  • J. Zweit1,2

1,2

1 1CR

CR-

  • UK/UMIST Radiochemical Targeting and Imaging, Paterson Institute

UK/UMIST Radiochemical Targeting and Imaging, Paterson Institute for for Cancer Research, Christie Hospital, Manchester M20 4BX, Cancer Research, Christie Hospital, Manchester M20 4BX,

2 2Department of Instrumentation and Analytical Sciences, UMIST, PO

Department of Instrumentation and Analytical Sciences, UMIST, PO Box 88, Box 88, Manchester, M60 1QD , UK. Manchester, M60 1QD , UK.

3 3Department of Physics, University of Strathclyde, Glasgow G4 ONG

Department of Physics, University of Strathclyde, Glasgow G4 ONG, Scotland. , Scotland.

4 4Central Laser Facility, CLCR Rutherford Appleton Laboratory, Chi

Central Laser Facility, CLCR Rutherford Appleton Laboratory, Chilton, lton, Didcot Didcot, , Oxon OX110QX, UK Oxon OX110QX, UK

M a n P E

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SLIDE 2

Positron Emission Tomography Positron Emission Tomography

Normally Cyclotron Produced Isotopes Normally Cyclotron Produced Isotopes

14 14N

N (p,n)

(p,n) 11

11C

C 20 20 mins mins

16 16O(p,

O(p,α α) )13

13N

N 10 10 mins mins

15 15N(p,n)

N(p,n)15

15O

O 2 2 mins mins

18 18O(p,n)

O(p,n)18

18F

F 1.7 hours 1.7 hours

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SLIDE 3

Laser Induced Protons for Isotope Production

slide-4
SLIDE 4

Schematic of the Vulcan Petawatt Laser

slide-5
SLIDE 5

Petawatt with Extensive Nuclear Shielding

slide-6
SLIDE 6

Primary Proton Generation Target Primary Proton Generation Target

  • Aluminium, gold and mylar foil targets (high

conductivity) of various thicknesses acted as the primary target.

  • Primary target irradiated by the laser beam

incident at an angle of 45˚.

  • The

protons emanated from water and hydrocarbon contamination layers

  • n

the primary target surfaces.

slide-7
SLIDE 7

Laser Target Set Laser Target Set-

  • up

up

slide-8
SLIDE 8

Enriched Oxygen Enriched Oxygen-

  • 18 Housing

18 Housing

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SLIDE 9

proton spectra in front of and behind a 10 proton spectra in front of and behind a 10 µ µ Al target. Al target.

The number of protons generated per laser shot at about 300J and 4x1020Wcm-2 was typically 1012.

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SLIDE 10

Laser driven PET isotope production

100KBq F-18 Produced in 1.5mL [18O]H2O enriched water from a single pulse of 750 fs (Isotope confirmed with gamma-ray spectroscopy)

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SLIDE 11

2 2-

  • [

[18

18F]FDG Synthesis Using Laser Induced F

F]FDG Synthesis Using Laser Induced F-

  • 18

18

slide-12
SLIDE 12

Laser driven F-18 isotope production

Vulcan Petawatt

Activity as function of laser intensity. The black hatched area is for typical patient dose for 18F.

slide-13
SLIDE 13

How can we increase the production to From KBq to MBq

  • Increase the energy per pulse to 1kJ or

greater

  • Flux of proton energy
  • Use a table top laser and integrate over

many pulses

  • Investigate targetry
  • collimation
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SLIDE 14

Acknowledgements Acknowledgements

  • Cancer Research-UK
  • University of Manchester
  • UMIST