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2/27/2017 Disclosures I have no relevant conflicts of interest or financial interests to disclose Ultraviolet Radiation Exposure in Work and Life Giorgia Louise Garrett MD Saturday March 11 th 2017 Occupational and Environmental Respiratory Disease


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Ultraviolet Radiation Exposure in Work and Life

Giorgia Louise Garrett MD Saturday March 11th 2017 Occupational and Environmental Respiratory Disease and Updates in Occupational and Environmental Medicine

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Disclosures

I have no relevant conflicts of interest or financial interests to disclose

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Overview

  • UV radiation
  • The story and biology of skin cancer
  • Cataracts
  • Miscellaneous

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UVA UVB VISIBLE IR 290 320 400 800 2500

Sunlight is the main source of UVR

UVC 100

  • Artificial UVR in the workplace: welding arcs,

germicidal lamps, devices for curing and drying printing ink, plastics, paint, UV lasers, mercury vapor lamps, medical UV therapy machines

  • Artificial UVR used recreationally: tanning beds
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Lim et al., JAAD, 2011

UVR has numerous effects UVR and the skin

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Only UVA and UVB reach the earth’s surface

UVA: ‐ 95% of natural UV radiation ‐ Penetrates deeper ‐ Responsible for photo‐aging UVB: ‐ 10,000 times more carcinogenic than UVA ‐ Promotes vitamin D synthesis

Acute vs. chronic exposure

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Diepgen et al. Dtsch Arztebl Int. 2012

Skin cancer

Non‐melanoma Skin Cancer (NMSC)

  • Most common cancer
  • Incidence rate

100/100,000 person‐year1

  • Mortality rate

~0.5/100,000 person‐year4

Malignant melanoma

  • Common deadly skin cancer
  • Incidence rate 23/100,000

person‐year2

  • Mortality rate 3/100,000

person‐years3

8 1 Madan et al. Lancet 2010 2 National Cancer Institute. Surveillance, Epidemiology, and End Results Program. 2016 3 Glazer et al. JAMA Derm 2016 4 Weinstock et al. JID 2007

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Squamous cell carcinoma

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  • Arise from normal skin or from actinic keratosis
  • 0.5% metastasize (esp. to lips, eyelids, and other mucous

membranes)

Actinic keratosis

  • Rough, reddened plaques
  • n sun exposed skin
  • Pre‐malignant: contain

morphologically cancer cells but invasion is limited to the most superficial part of the dermis

  • ~13% develop into SCC

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Basal cell carcinoma

  • Smooth, shiny

lesion with telangiectasia

  • Nodular or

ulcerated lesion

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  • Rarely metastasizes but

can be locally very destructive

Malignant melanoma

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2/27/2017 4 Is it benign or malignant? The ABCDE tool.

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Risk factors for skin cancer

  • UVR is the most important risk factor for skin

cancer

– Cumulative: SCC – Intermittent: melanoma, BCC

  • 1992: International Agency for Research on

Cancer (IARC) accepted solar UVR as a human carcinogen1

  • Fair skin type, family or personal history of skin

cancer, male gender, southern latitude, age >50 and immunosuppression increase the risk further

  • Behavior related to UV exposure: preventable

14 1 http://www.iarc.fr/

Skin cancer: an occupational disease?

  • 1890, Unna: changes of the skin were observed in

sailors

  • Skin Cancer Foundation: outdoor workers are

twice as likely to contract skin cancer as indoor workers

  • Outdoor: >3 hours/day on a typical work day
  • Long outdoor hours, shifts at 10am‐2pm, working

in altitude, near the equator, and doing repetitive tasks in the same position increases the risk further

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Occupational UV exposure increases the risk of cutaneous SCC

Schmitt et al. BJD. 2011

18 studies Pooled OR 1.77 (95% CI 1.40‐2.22, p<0.001) P for heterogeneity <0.001

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Strength of the association increases with decreasing (more southern) latitude

Schmitt et al. BJD. 2011

*Log‐odds ratio (OR) of the relationship between occupational UV light exposure and SCC †Absolute value of latitude

Occupational UV exposure increases the risk

  • f basal cell carcinoma

Bauer et. al BJD. 2015

23 studies Pooled OR 1.43 (95% CI 1.23‐1.66, p<0.0001) P for heterogeneity=0.0001

What about occupational melanoma?

  • Trakatelli et al., 2016: outdoor workers

chronically exposed to UVR are not at increased risk of melanoma compared to indoor workers

  • Sanlorenzo et al., 2015: airline pilots and crew

cabin have twice the incidence and mortality of melanoma compared to the general population

  • Outdoor workers: head and neck melanoma,

indoor workers: chest or limb melanoma

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Trakatelli et al. BJD. 2016 Sanlorenzo et al. JAMA Derm. 2015

Germany, 2015: skin cancer is a new

  • ccupational disease
  • Cutaneous SCC and multiple AK (>6 within a

12 month period) due to solar UVR established as a new occupational disease

  • BCC, melanoma and all skin cancer caused by

artificial UV radiation are not

  • UK: compensation scheme for war veterans

who served in tropical countries and later developed skin cancer

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Establishing the occupational causation of skin cancer

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Occupational UV exposure is >40 %

  • f recreational UV

exposure at the time of diagnosis (Acarc)

Work activity needs to double the risk of skin cancer

Diepgen et al. JDDG. 2016

Work‐related criteria contributing to

  • ccupational skin cancer
  • The individual has to have worked a substantial part of their

work life outdoors

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  • Greater exposure is attributed to working closer to the

equator or at high altitude

  • If only part of the day was spent working outdoors the
  • ccupational activity has to have been performed for a

longer period of time

Diepgen et al. JDDG. 2016

Clinical requirements for the diagnosis of

  • ccupational skin cancer

Location of tumor On irradiated sites Confirmation of diagnosis SCC: by histopathology Multiple AK: clinical diagnosis*

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  • Clinical criteria must be met:
  • Medical experts, accident insurance, court make a final decision

Signs of chronic UV damage Distribution in occupationally exposed body areas corroborate the diagnosis Fitzpatrick skin phototype Provided with the report, does not form part of the diagnosis Non occupational risk factors These are taken into account: immunosuppression, presence of photosensitizing drugs Additional 40% occupational UV exposure As calculated by the occupational accident insurance Differences with respect to vacation activities Number and location of vacation and leisure activities

  • Other factors included in the report that are taken into account:

Diepgen et al. JDDG. 2016

Occupational skin cancer in the US

  • 5 million outdoor workers in the US
  • UVR: one of the most frequent occupational

carcinogens in American workplaces

  • Not formally recognized, but Howard Maibach

MD has called it occupational for 40 years

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2/27/2017 7 ICNIRP: preventing occupational skin cancer

  • Education on health hazards resulting from the

sun

  • Minimize outdoor work during midday hours in

spring and summer (staggering shifts)

  • Lunch breaks in the shade
  • Clothing: long sleeve, hats
  • Eye protection: wrap around design, UVR

protection

  • Broad spectrum sunscreens (SPF> 30), no sun

beds

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Shade and long sleeves are best sun protection measures

Linos et al., Cancer Causes Control, 2006

Shade and long sleeves increase risk of vitamin D deficiency

Linos et al., Cancer Causes Control, 2006

My advice for patients

Stay in the shade Avoid midday sun Wear a hat Wear long sleeves Use sunscreen (say this last) Take vitamin D in those who ‘look’ deficient

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Tanning beds

  • Indoor tanning beds: increased risk of skin

cancer

  • Melanoma: risk even higher if use begins

before age 35 years1

  • WHO, 2009: tanning beds are carcinogenic to

human beings2

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  • 1. Green. Int J Cancer, 2007
  • 2. Ghissassi et al., Lancet Oncol. 2009

Cataracts

  • UV radiation of wavelength <300nm can damage the

corneal epithelium

  • This is most commonly the result of exposure to the

sun at high altitude or in areas where shorter wavelengths are reflected by bright surfaces (snow, sand, water)

  • Exposure to radiation to a welding arc can cause

welder’s flash burn, a form of keratitis

  • Sudden onset of pain after a latent period of several

hours due to epithelial cell sloughing

  • Treatment: antibiotic ointment, patches until the

epithelium heals

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Miscellaneous

  • UVR acts as an immunosuppressant: used to

treat inflammatory skin conditions such as psoriasis

  • UVR and burns

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Thank You

Occupational Medicine: Paul Blanc, MD Dermatology: Howard Maibach, MD Sarah Arron, MD PhD Eleni Linos, MD MPH

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