Cell Physiolgy By: Dr. Foadoddini Department of Physiology & - - PowerPoint PPT Presentation

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Cell Physiolgy By: Dr. Foadoddini Department of Physiology & - - PowerPoint PPT Presentation

Sep 24, 2022 695 likes •1.33k views

Cell Physiolgy By: Dr. Foadoddini Department of Physiology & Pharmacology Birjand University of Medical Sciences Dr. Foadoddini Functional Organization of the Human Body and Control of the "Internal Environment" Transport of

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Cell Physiolgy

By: Dr. Foadoddini

Department of Physiology & Pharmacology Birjand University of Medical Sciences

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Functional Organization of the Human Body and Control of the "Internal Environment"

Transport of Substances Through the Cell Membrane

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Negative Feed-back Positive Feed-back Feed-forward (Adaptation) Control mechanisms:

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Membrane Resistance Conductance

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Na+‐K+ ATPase.

ATP ADP

3 Na+

2 K+ Digitalin Digitalin P

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J = -DA dC/dx

Fick law:

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ﻢﻴﺣﺮﻟا ﻦﻤﺣﺮﻟا ﷲا ﻢﺴﺑﻢﻴﺣﺮﻟا ﻦﻤﺣﺮﻟا ﷲا ﻢﺴﺑ

Cell Physiolgy

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Membrane Potentials and Action Potentials

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E Na= +61 mV E K = -94 mV

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Goldman equation:

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Self –Assessment (Bern)

  • 1. With reference to the situation diagrammed

below, which statement is true?

  • A. CI- is in equilibrium.
  • B. K+is in equilibrium.
  • C. There is a net tendency for K+to diffuse

from B to A.

  • D. Work is required to cause K+to flow from B

to A.

B C

  • 2. In the "concentration cell" depicted below,

the membrane is permeable to Cl- but completely impermeable to K+. Which statement is true?

  • A. K+will diffuse from A to B.
  • B. A potential difference EA- EB of +60 mV

will develop.

  • C. Absolutely no Cl- will flow from A to B.
  • D. Both K+and CI- will attain equilibrium.
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TTX TEA

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Other onines Role of Ca

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Threshold / Firing level

Stimulus: Types Amplitude Duration

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Direction of impulse All –or- None Law A Positive-feedback Vicious Cycle Opens the Sodium Channel

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Effect of excess sodium ions accumulate inside the cell membrane. Re-establishing Ionic Gradients After Action Potentials "recharging”

  • f the nerve fiber is an active metabolic process
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Slow Ca-Na voltage channel Latency in K voltage channel Importance of plateau

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Rhythmicity Cardiac m.: heart rate Smooth m.: peristalsis of the intestines CNS: neural event eg: control of breathing. REPETITIVE DISCHARGE Effect of Veratrine

  • r low evel
  • f Ca on N. or M.

permeable enough to sodium ions or calcium to allow automatic membrane depolarization. "resting" membrane potential is only - 60 to -70 mV Hyperpolarization: for a short period thereafter, the membrane becomes excessively permeable to potassium ions

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sphingomyelin. is an excellent electrical insulator that decreases ion flow through the membrane about 5000-fold

saltatory conduction.

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saltatory conduction increases the velocity of nerve transmission requiring little metabolism Repolarization to occur with very little transfer of ions

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Membrane stabilizing factors: Ca Local Anesthesia: procaine, tetracaine

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