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Alternative Use of Silicon Edoardo Charbon TU Delft Alex Dommann - PowerPoint PPT Presentation

Alternative Use of Silicon Edoardo Charbon TU Delft Alex Dommann EMPA Pantelis Georgiou Imperial College London Bruno Murari ST Microelectronics Roland Thewes TU Berlin Chair: Giovanni De Micheli, EPFL Edoardo Charbon TU Delft


  1. Alternative Use of Silicon Edoardo Charbon TU Delft Alex Dommann EMPA Pantelis Georgiou Imperial College London Bruno Murari ST Microelectronics Roland Thewes TU Berlin Chair: Giovanni De Micheli, EPFL

  2. Edoardo Charbon TU Delft

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  17. Alex Dommann EMPA

  18. Pantelis Georgiou Imperial College London

  19. Bio-ins io-inspir pired ed Semiconduct emiconductor ors for or Healt Healthcar hcare e Dr. . Pant antelis elis Geor Georgiou giou (pantelis@imperial.ac.uk) Centre for Bio-inspired Technology, Institute of Biomedical Engineering, Department of Electrical and Electronic Engineering Alt lter erna nativ ive e us uses es of of Silicon ilicon Sympos mposium ium on on Emer merging ging trends ends in in Elect lectronics onics 2 nd nd December ecember 2014 2014

  20. Can we leverage on $1 trillion investment in Microelectronics to create more affordable healthcare? CMOS Opportunities Needs of Modern Healthcare • Scalable • Health services originally • Repeatable designed to manage acute • Low cost illness (i.e. infections and • Miniaturization injury) • System Integration • Today, however 70-78% of • Dedicated performance health budget expenditure is (low noise, low power) on Chronic Disease! Personalised Healthcare • Technology from Hospital to the Home - New Wave Lifestyle • Medical devices towards consumer devices Page 21 21 B23,#2&6%#&C(%?(3/+(#21&^2$43%)%79 &&&&&&&&&&&&&&&&&&&&&&&&& &&&&&&&a#;&`"3,2)(/&'2%#7(%0 & & & &&

  21. DNA Testing Today Min. 2 weeks Healthcare Application • Point-of-Care Diagnostics • Sequencing Technology SNP Chip of the Future DNA Testing at Imperial: No Lab 15 – 20 mins To read your DNA Source: DNA electronics website (www.DNAe.co.uk) Page 22 22 B23,#2&6%#&C(%?(3/+(#21&^2$43%)%79 &&&&&&&&&&&&&&&&&&&&&&&&& &&&&&&&a#;&`"3,2)(/&'2%#7(%0 & & & &&

  22. Combined DNA Amplification and Detection in CMOS CMOS is cheap, integration is expensive, how do we break Ion-Sensitive Field this barrier of co-design? Effect Transistor Features • Fully unmodified CMOS • Detect Hydrogen ions using Ion-sensitive Field Effect Transistors. • Can use heating to amplify DNA through PCR (polymerase chain reaction) • Use a reference chamber to do differential measurement and cancel out chemical drift. C.Toumazou, et al.,“Simultaneous dna amplification and detection using a pH-sensing semiconductor system,” Nature methods, 2013. 23 B23,#2&6%#&C(%?(3/+(#21&^2$43%)%79 &&&&&&&&&&&&&&&&&&&&&&&&& &&&&&&&a#;&`"3,2)(/&'2%#7(%0 & & & &&

  23. Semiconductor DNA sequencing • Moores law has already found its way to DNA sequencing using ISFETs! Source: ion Torrent website (www.iontorrent.com) Page 24 24 B23,#2&6%#&C(%?(3/+(#21&^2$43%)%79 &&&&&&&&&&&&&&&&&&&&&&&&& &&&&&&&a#;&`"3,2)(/&'2%#7(%0 & & & &&

  24. Whole Genome Sequencing Costs The $100 Genome? • Rapidly reducing costs! • When is Moore enough? • Challenges: • Things difficult to detect at smaller volumes • Noise, mismatch • Reliability of sensors • Micro-fluidic integration • Data Bandwidth • Bio-informatics, Big data How can we scale CMOS sensors and fluidics reliably to exploit Moore? Wetterstrand KA. DNA Sequencing Costs: Data from the NHGRI Genome Sequencing Program (GSP) Page 25 25 B23,#2&6%#&C(%?(3/+(#21&^2$43%)%79 &&&&&&&&&&&&&&&&&&&&&&&&& &&&&&&&a#;&`"3,2)(/&'2%#7(%0 & & & &&

  25. Diabetes Current Treatment Glucose measurement Insulin injection Artificial Pancreas • Insulin injection solves the problem Sub-optimal treatment in the short term . • Diabetics still spend a large amount of time in the hyper-glyceamia • Leading cause of blindness, kidney failure, heart disease, neurogenic disease. Page 26 26 B23,#2&6%#&C(%?(3/+(#21&^2$43%)%79 &&&&&&&&&&&&&&&&&&&&&&&&& &&&&&&&a#;&`"3,2)(/&'2%#7(%0 & & & &&

  26. Can we use a Bio-inspired Approach? Novel Medical Devices Pancreatic Beta Cells Microchips Semiconductor technology Therapy Miniature, Low-power Biology Low-cost The Pancreas Page 27 27 B23,#2&6%#&C(%?(3/+(#21&^2$43%)%79 &&&&&&&&&&&&&&&&&&&&&&&&& &&&&&&&a#;&`"3,2)(/&'2%#7(%0 & & & &&

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