Allergy and Hypersensitivity K. J. Goodrum 2006 Types of Immune - PDF document

Types of Immune Hypersensitivity Reactions Allergy and Hypersensitivity K. J. Goodrum 2006 Types of Immune Hypersensitivity Reactions Properties of Inhaled Allergens 1

Penetration of epithelial Barriers by Allergens Early IL-4 response promotes Th2 development that drives B cell class switching to IgE Antigen binding to IgE on mast cells leads to amplification of IgE production Signaling through Stat6 is necessary for Th2 responses. Th2 cells support IgE responses. 2

Mast cell Molecules released upon activation of mast cells activation affects many tissues Toxic granule proteins and inflammatory substances Molecules released upon activation of mast cells released upon activation of eosinophils 3

Toxic granule proteins and inflammatory substances Acute vs. released upon activation of eosinophils late phase inflammatory responses Treatment approaches for IgE-mediated Allergy TH2 mediated chronic inflammation in Asthma 4

Type II Cytotoxic Immune Complex mediated local inflammation such as reaction in Arthus Reaction Serum Sickness: an Immune complex disease 5

Type IV Hypersensitivity Reactions Stages of a Type IV Hypersensitivity Reaction Th1 derived cytokines and Allergic Contact Dermatitis: A type IV reaction chemokines direct Type IV reactions 6

Granulomatous inflammation is a consequence of chronic Type IV reactions Blistering skin lesions on hand of patient with poison ivy contact dermatitis (a type IV reaction) 7