accelerated photodynamic cancer therapy planning with
play

Accelerated Photodynamic Cancer Therapy Planning with FullMonte Jeffrey Cassidy, PhD Candidate University of Toronto (Canada) #OpenPOWERSummit Photodynamic Therapy (PDT) for Cancer Photosensitizer Light Exposure (drug) (fluence J/cm 2 )

0 downloads 10 Views 1,43 MB Size Report
  1. Accelerated Photodynamic Cancer Therapy Planning with FullMonte Jeffrey Cassidy, PhD Candidate University of Toronto (Canada) #OpenPOWERSummit

  2. Photodynamic Therapy (PDT) for Cancer Photosensitizer Light Exposure (drug) (fluence J/cm 2 ) Multiple FDA- approved drugs � Surface illumination, Topical, IV, or oral Implanted fibre, or intraoperative Tissue Oxygen Cells killed Normally present in tissue Join the conversation at #OpenPOWERSummit 2

  3. Photodynamic Therapy (PDT) for Cancer ▪ Benefits ▪ Very low systemic toxicity ▪ Repeatable ▪ Highly targeted ▪ Simple, inexpensive delivery ▪ Single-shot, possibly outpatient basis � ▪ Challenges ▪ Variable outcomes ▪ Compute-intensive to model � � Join the conversation at #OpenPOWERSummit 3

  4. Photodynamic Therapy (PDT) for Cancer ▪ Current use ▪ Skin (basal-cell carcinoma, actinic keratosis) ▪ Superficial oral cavity � ▪ Trials ▪ Prostate ▪ Bladder ▪ Head & neck Brain ▪ � Bladder model � Join the conversation at #OpenPOWERSummit 4

  5. PDT Treatment planning � ▪ Many sims required � ▪ Many free parameters � ▪ Properties variable ▪ Minutes per sim on CPU � � Simulate Image Delineate Define dose Approve planning Propose plan organs parameters plan volume Image courtesy Robert Weersink, Princess Margaret Cancer Centre Join the conversation at #OpenPOWERSummit 5

  6. PDT Treatment planning Join the conversation at #OpenPOWERSummit 6

  7. FullMonte simulation kernel Monte Carlo simulation traces photons through tetrahedral mesh Launch Draw Region Hop Interface step lookup Drop Exit Spin Dead “Digimouse” open-source mouse atlas (standard pre-clinical model) Join the conversation at #OpenPOWERSummit 7

  8. 
 FullMonte simulation kernel � � � Launch � � � ▪ Altera Stratix V FPGA Draw Region Hop Interface step lookup � ▪ Flow stages <-> hardware modules Drop Exit � ▪ Queues at join points � 1 step/clk @ 250 MHz ▪ Spin Dead � Join the conversation at #OpenPOWERSummit 8

  9. Preliminary Results *Prototype x86-hosted system, limited (48k) mesh size Performance FPGA* 4 FPGA + server Metric 1 instance @ 4 inst/FPGA (<25% area) (projected) Throughput / node 4x 64x Throughput / $capital 0.95x 3.6x Throughput / W 67x 41x Intel Sandy Bridge (32nm) i7-2600K 3.6 GHz 4-core HT gcc –O3, multithreaded, hand-tuned SSE4 Price $1200 (excl. GPU & monitor) � Altera Stratix V (28nm) at F max =280MHz Quartus II PowerPlay power estimation 4.5W single instance Price $5000 (Nallatech 385 list price) � Join the conversation at #OpenPOWERSummit 9

  10. OpenPOWER/CAPI Scale-up CAPI platform: � ▪ Enables large meshes (no more 64k limit) ▪ On-chip cache for most frequently accessed ▪ Host serves long tail via CAPI � ▪ Maintains power & performance advantage � ▪ Provides support code (host & FPGA side) � ▪ Supports fast host-accelerator communication � � Join the conversation at #OpenPOWERSummit 10 � �

  11. OpenPOWER/CAPI Scale-up Digimouse (lung tumour) 1 Static LRU Hybrid Oracle 0.75 FPGA memory Miss Rate capacity 0.5 � Misses served by CAPI 0.25 0 1 2 4 8 16 32 64 128 256 512 1k 2k 4k 8k 16k 32k 64k Cache Size (elements) 1 Join the conversation at #OpenPOWERSummit 11

  12. OpenPOWER/CAPI Scale-up Simple hybrid cache Digimouse (lung tumour) � 4 Static LRU Hybrid ▪ L1 4-el. LRU Miss Rate (relative to Oracle=1.0) ▪ L2 N-el. static 3 ▪ Most frequent ▪ Banked 2 Host-managed ▪ � 1 -32% misses vs. pure LRU and simpler to implement 0 64k 1 2 4 8 16 32 64 128 256 512 1k 2k 4k 8k 16k 32k � Cache Size (elements) +60% vs. clairvoyant (perfect prediction) 3 Join the conversation at #OpenPOWERSummit 12 2

  13. & BlueLink � ▪ Designed with Bluespec SystemVerilog (BSV) ▪ Atomic rules for complex concurrency ▪ High performance Strong typing, good IP library, fast sim ▪ � ▪ Created open-source BSV library BlueLink ▪ Interface to IBM CAPI hardware & sim env. ▪ Simplified module interface ▪ IP for host <-> FPGA xfer to reg/MLAB/ BRAM ▪ Examples � github.com/jeffreycassidy/bluelink (work in progress) � Join the conversation at #OpenPOWERSummit 13 �

  14. Summary MC photon transport simulation on tetrahedral mesh � ▪ Performance per Watt -> FPGA ▪ Fixed-point (18b) arithmetic ▪ Spatial dataflow pipeline ▪ Inexpensive, effective custom caching � ▪ Tight host-FPGA coupling -> OpenPOWER CAPI ▪ Large meshes (>> FPGA on-chip mem.) ▪ Host mem. serves infrequent items ▪ Host-managed static cache set � >40x more performance/W vs CPU � Join the conversation at #OpenPOWERSummit 14 �

  15. Acknowledgements PhD Supervisors Prof. Vaughn Betz, Univ. Toronto ECE Prof. Lothar Lilge, Princess Margaret Cancer Centre � Funding IBM, Altera, CIHR, NSERC � In-Kind Support IBM, SOSCIP , Altera, Bluespec � Discussion Robert Weersink, PMCC Henry Wong, U Toronto Join the conversation at #OpenPOWERSummit 15

Recommend Documents


photodynamic therapy in the management of periorbital
PHOTODYNAMIC THERAPY IN THE MANAGEMENT

PHOTODYNAMIC THERAPY IN THE MANAGEMENT OF PERIORBITAL SKIN CANCER Jerjes W,

dr richard fuller
Dr Richard Fuller (Click or use arrow

Sonodynamic Photodynamic Therapy Dr Richard Fuller (Click or use arrow keys to

invion
INVION Transforming Photodynamic

INVION Transforming Photodynamic Therapy: for novel & effective

photodynamic therapy in the management of basal cell
PHOTODYNAMIC THERAPY IN THE MANAGEMENT

PHOTODYNAMIC THERAPY IN THE MANAGEMENT OF BASAL CELL CARCINOMA: RETROSPECTIVE

critical review surgical site infections subjected to
Critical review Surgical site

Trauma & Orthopaedics Page 1 of 8 Critical review Surgical site

critic al r eview spinal metastasis subjected to
Critic al r eview Spinal metastasis

Trauma & Orthopaedics Page 1 of 7 Critic al r eview Spinal metastasis

antiproton cancer therapy ad 4 ace 4 ace antiproton
Antiproton Cancer Therapy AD- -4/ACE

Antiproton Cancer Therapy AD- -4/ACE 4/ACE Antiproton Cancer Therapy AD

duration of adjuvant therapy for colon cancer
Duration of Adjuvant Therapy for Colon

Duration of Adjuvant Therapy for Colon Cancer Anthony F. Shields, M.D., Ph.D.

tailored adjuvant systemic therapy for breast cancer
TAILORED ADJUVANT SYSTEMIC THERAPY FOR

TAILORED ADJUVANT SYSTEMIC THERAPY FOR BREAST CANCER THERAPY FOR BREAST

chimeric antigen receptor car t cell therapy a cure for
Chimeric Antigen Receptor (CAR) T Cell

Chimeric Antigen Receptor (CAR) T Cell Therapy: A Cure for Cancer? Michael

better safe
BETTER SAFE WELCOAS ONLINE BULLETIN

H E A LT H B U L L E T I N S BETTER SAFE WELCOAS ONLINE BULLETIN FOR YOUR FA

a skin gazers eye to wound care and skin lesions
A SKIN GAZERS EYE TO WOUND CARE AND

A SKIN GAZERS EYE TO WOUND CARE AND SKIN LESIONS BY: LAURA JANE HOLSEY, DO

work place carcinogens
Work Place Carcinogens Solar Radiation

Work Place Carcinogens Solar Radiation and Skin Cancer November 2013 Dr Mark

creating an environment in
Creating an environment in which

Creating an environment in Creating an environment in which cancer cannot

lesson plan muscular system 1
Lesson Plan: Muscular System 1 5

Lesson Plan: Muscular System 1 5 minutes: Breath of Arrival and Attendance

feedback from prac
Feedback from PRAC March 2020 An

Feedback from PRAC March 2020 An agency of the European Union

next science limited investor presentation
Next Science Limited Investor

Innovations powered by technology Next Science Limited Investor Presentation

er yag laser technology made in germany
- Er:YAG Laser - Technology Made in

MCL31 Dermablate - Er:YAG Laser - Technology Made in Germany For more than

skin cancer surface shape based classification
Skin Cancer Surface Shape Based

Skin Cancer Surface Shape Based Classification Steven McDonagh March 10, 2008

q2 2017 update
Q2 2017 UPDATE Robert Tessarolo,

Q2 2017 UPDATE Robert Tessarolo, President & CEO Stephen Lemieux, CFO