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MCL31 Dermablate - Er:YAG Laser - Technology Made in Germany For more than 35 years, Asclepion has been operating on the medical laser market. As the company is based in Jena, famous through the world as the global center of the optics


  1. MCL31 Dermablate - Er:YAG Laser -

  2. Technology „Made in Germany“ For more than 35 years, Asclepion has been operating on the medical laser market. As the company is based in Jena, famous through the world as the global center of the optics industry since 1846, the company owes it success to the steady development of new technologies and the active collaboration with researchers from German universities and industries. • More than 35 years experience in the aesthetic laser medicine and surgery • Development, production, service & training center in Jena • TOP100 of the most innovative medium-sized businesses in Germany MCL31 100 1116 EN 2

  3. The sixth generation of the Dermablate series MCL29 Dermablate The first Er:YAG laser for dermatology was introduced in Dermablate D1 Milestones of product introduction of Er:YAG laser 1995 by Asclepion. Now we present the sixth generation for dermatological and aesthetic DermaStar laser medicine – stronger, faster, more efficient, flexible: MCL30 Dermablate MCL31 Dermablate. Dermablate Effect MCL31 100 1116 EN 3

  4. Specifications Laser: Er:YAG, class 4 Wavelength: 2,940 nm Energy: Max. 2.5 J Fluence: Max. 250 J/cm² Pulse duration: 100 – 1000 µs Frequency: 1 – 20 Hz Modes: Ablation, Therm, MicroSpot, Gyn* Spot size Ablation: 1 – 6 mm (Vario) 8 – 12 mm (Vario XL*) Spot size MicroSpot*: 13x13mm with variable skin coverage rate of 10 – 25% Spot size Gyn*: V-Spot with 90 ° reflecting gold-coated mirror V-Spot with 360 ° reflecting gold-coated cone Dimensions: 36 x 60 x 93 cm (W x D x H) Weight: Approx. 75 Kg * Optional * Available with the Juliet upgrade MCL31 100 1116 EN All specifications are subject to change without notice. 4

  5. Clinical success and USPs Clinical success USPs • 1990: first clinical trials by R. Kaufmann et al. • integrated suction system • 1996: MCL29 Dermablate was the first Er:YAG • VarioTEAM technology • MicroSpot technology laser in dermatology introduced by Aesculap- • variable coverage and pulse length Meditec (Asclepion), more than 800 systems • Sub-ablative mode (coagulation mode) worldwide • sterilizable distance holder Germany: The Dermablate has became a • most homogeneous beam profile standard tool for dermatologists in the • thermal mode treatment of a wide range of coetaneous lesions • more than 20 years experience • unbeaten reliability, fast amortization • Footswitch for adjusting the fluence MCL31 100 1116 EN 5

  6. Er:YAG vs. CO 2 Advantages of the Er:YAG laser and handpiece technology Ablativ (VarioTEAM) • precise and safe ablation • very limited thermal damage (necrotic zone 30µm/70µm) • superficial treatments possible as well as deep ablation • reduced risk of scarring and pigmentation changes • many treatments require no anaesthesia • short healing process, little side effects Fractional (MicroSpot) • integrated smoke evacuation • new designed and patented handpiece • automatic suction and lens cleaning • cooling outlets integrated in distance holders • maintenance free • Microlens technology with 169 fractional spots per shot • up to 20 Hz (quickest fractional technology available) MCL31 100 1116 EN 6

  7. Integrated filter system • integrated smoke evacuation • suction directly at the treatment area • activation by footswitch for reduced noise pollution • more powerful smoke evacuation* • up to 50% quieter smoke evacuation (-6dB)* • handpiece with patented TEAM technology ( T otal E vacuation of A blated M aterial) • easy change of filters HEPA filter ( H igh E fficiency P articulate Air filter ) Active coal – filter Pre-filter Triple filter system MCL31 100 1116 EN * compared to the previous model MCL30 Dermablate 7

  8. VarioTEAM handpiece VarioTEAM handpiece (Ablation) with TEAM-Technology (Total Evacuation of Ablated Material)  very effective smoke evacuation  lowest smell nuisance  no assistance necessary  cost reduction  patents: US 6 162 218 DE 197 106 76 with VarioSpot-Technology VarioTEAM handpiece with variable spot size  spot size from 1 to 6 mm adjustable in 1mm steps  spot size from 8 to 12 mm adjustable in 2mm steps  automatic spot size detection  automatic fluence adaption MCL31 100 1116 EN 8

  9. MicroSpot handpiece Laser beam input MicroSpot handpiece (Fractional) with MicroSpot-Technology  use of stable and precise microlens array technology  integrated smoke evacuation (TEAM-Technology)  air cooling adaptable (e.g. cooling from Zimmer) Micro-lens array MicroSpot output  very flexible adjustment of ablation depth through fluence  very flexible adjustment of cover rate through variable coverage of 10 to 25%  controlled thermal effect with selectable pulse duration EPIDERMIS DERMIS MAZ* MAZ* MAZ* MCL31 100 1116 EN * MAZ = Microscopic ablation zone by Dr. Bettina A. Buhren & Dr. Peter A. Gerber, Clinic of Dermatology, Dusseldorf, Germany 9

  10. Beam profile Flat-Top beam profile most homogeneous spot Ablation Fractional MCL31 100 1116 EN 10

  11. Ablation vs. Fractional Classical Skin Resurfacing with VarioTEAM handpiece Almost 100% of the epidermal layer will be completely removed (Depth of ablation is variable). -> accordingly long wound healing Fractional treatment with MicroSpot handpiece Only 10-25% of the epidermal layer will be completely removed (depth of ablation is variable). -> fast wound healing, supported by the untreated skin MCL31 100 1116 EN 11

  12. Ablation vs. Coagulation Ablation vs. Fluence - different mechanism of Er:YAG - Ablation in µm Linear correlation • constant ablation depth of 5 µm per 1 J/cm² (above ablation threshold) • The higher the FLUENCE, the more skin will be removed. Thermal Mode • Specs: 1 J/cm², 20 Hz, N = 5 ...  • coagulation zone up to 400 µm depth (with single impulse up to 40 µm) Fluence in J/cm 2 MCL31 100 1116 EN 12

  13. Ablation vs. Coagulation 30 Coagulation depth µm as function of pulse length µs 25 20 15 10 5 0 0 125 250 375 500 625 750 875 1000  Ablation: increased visibility in the treatment area, thanks to less bleeding  Fractional: thermal effect for skin tightening MCL31 100 1116 EN 13

  14. Ablation vs. Coagulation MicroSpot: Flexibility combined with effectiveness unique results thanks to variability of the cover rate and pulse length Setting E10% N10% N25% C10% W25% Mode Expert Normal Normal Cold Warm Spot number 169 13 x 13 mm 2 Size pattern Energy per pulse (J) 1.6 J 0.8 J 2.0 J 0.6 J 2.0 J Fluence per pulse 10 5 5 4 4 Cover rate 10% 10% 25% 10% 25% Pulse length (µs) 300 300 300 100 1,000 Recommended pulses 2-3 3-4 3-4 4 4 MCL31 100 1116 EN 14

  15. Display Easy to use • clear menu navigation • touch-sensitive display • different background colors selectable Modes Settings Purpose Ablation Fluence, pulse length, Frequency, spot size* Ablation Therm Fluence, pulse number, time between pulses (interval), spot size* Thermal MicroSpot Fluence, pulse length, time between pulses (interval), coverage** Fractional TOOLS Pilot beam brightness, background colors, pulse rate, filter usage etc. Defaults * Spot size is set directly on the handpiece ** Coverage is set directly on the handpiece MCL31 100 1116 EN 15

  16. Design Modern design • elegant • mobile • space saving • ergonomic handpieces • balanced spring articulated mirror arm • articulated mirror arm with a long range (110cm)* • footswitch for adjusting the fluence MCL31 100 1116 EN * Arm about 25% longer than the previous model MCL30 Dermablate 16

  17. Selective absorption 100000 High absorption in water 10000 Low absorption in Desoxy-Hemoglobin 1000 melanin Absorption Coefficient [cm -1 ] Protein Water and hemoglobin 100 Melanin 10 Selective thermolysis 1 (effective targeting and low Oxy-Hemoglobin 0.1 side effects) 0.01 Scattering 0.001 0.0001 100 200 300 400 500 1000 2000 3000 4000 5000 10000 Wavelength [nm] MCL31 100 1116 EN 17

  18. Indications • Removal of dermal and epidermal lesions: epidermal naevi, Keratosis seborrhoeic, warts, naevus cell naevus, hypertrophic scars, acne scars, xanthelasma, rhinophyma, wrinkles, Lentigines, actinic Keratosis, Syringomas • Full skin resurfacing • Soft laser peel • Skin refreshing • Fractional laser therapy Smoothes fine lines, wrinkles and rhytids; perfectly blends uneven pigmentation; minimizes the size of pores; dramatically clears photo-damaged skin; fills in acne scars MCL31 100 1116 EN 18

  19. Indications | Dermablation MCL31 100 1116 EN 19

  20. Indications | Dermal nevus MCL31 100 1116 EN By courtesy of Dr. Said Hilton & Heike Heise, Medical Skin Center, Dr. Hilton & Partners, Dusseldorf, Germany 20

  21. Indications | Epidermal nevus MCL31 100 1116 EN By courtesy of Dr. R. Hartmann, Blaustein, Germany 21

  22. Indications | Fibro adenoma MCL31 100 1116 EN By courtesy of Dr. Klaus-Peter Koch, Harsefeld, Germany 22

  23. Indications | Xanthelasma Parameters: 2 mm Spot, 18 J/cm 2 , 10 Hz MCL31 100 1116 EN By courtesy of Dr. Peter Arne Gerber, Clinic of Dermatology, Dusseldorf, Germany 23

  24. Indications | Xanthelasma Parameters: 2 mm Spot 18 J/cm 2 10 Hz KTP-Laser (532 nm) MCL31 100 1116 EN By courtesy of Dr. Peter Arne Gerber, Clinic of Dermatology, Dusseldorf, Germany 24

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