ZI VAK TECHNOLOGI ES Multitasker-LC Walk Away UHPLC Analyzer For - - PowerPoint PPT Presentation
ZI VAK TECHNOLOGI ES Multitasker-LC Walk Away UHPLC Analyzer For LC-MS/MS Clinical Diagnostic Market Roche, Siemens,Midray Sciex, Agilent, Thermo Abbott, Beckman Shimadzu, Waters.. Currrent Clinical Diagnosis Clinical with Diagnostic
Immunoassay, ELISA, RIA,FIA Gold Standart Methods Roche, Siemens,Midray Abbott, Beckman Sciex, Agilent, Thermo Shimadzu, Waters..
Currrent Clinical Diagnostic Market Clinical Diagnosis with LC-MS/MS and HPLC
than 40 nmol/L but one or more of the immunoassays gave greater than or equal to 40 nmol/L.
State-of-the-Art Vitamin D Assays: A Comparison of Automated Immunoassays with Liquid Chromatography–Tandem Mass Spectrometry Methods Christopher-John L. Farrell,1,2 Steven Martin,1 Brett McWhinney,3 Isabella Straub,4 Paul Williams,5 and Markus Herrmann1,4* Clinical Chemistry 58:3 531–542 (2012)
Immunoassay, ELISA, RIA,FIA %95-97 Gold Standart Methods %3-5 Roche, Siemens,Midray Abbott, Beckman Sciex, Agilent, Thermo Shimadzu, Waters..
Ready to Use Analysis Kits Automation and Barcode Reading Walk-away HPLC and LC-MS/MS Analysers
Currrent Clinical Diagnostic Market Clinical Diagnosis with LC-MS/MS and HPLC
Advantages Disadvantages
MS/MS methods
High Specificity High Sensitivity Lower Kit Costs Multiplexing Measurements High Throughput Non-Automated Qualified staff required The need of rigorous kit validation Automated Barcode Reading Direct injection from Vacu tube Higher maintenance cost (20 K USD / year) Higher owner capital cost (200 K USD / device)
Immunoassay
Automated No need for qualified staff Validated kits Affordable prices Better traceability (barcode readers, Online LIS connection) Low Specificity Low Sensitivity Higher Kit Costs High Potential for interference
Advantages Disadvantages
Zivak Multitasker Automated LC-MS/MS System
High Specificity High Sensitivity Lower Kit Costs Multiplexing Measurements High Throughput
Non-Automated Qualified staff required The need of rigorous kit validation Automated Barcode Reading Direct injection from Vacutube Online LIS connection Higher maintenance cost (20 K USD / year) Higher owner capital cost (200 K USD / device)
Immunoassay
Automated No need for qualified staff Validated kits Affordable prices Better traceability (barcode readers, Online LIS connection)
Low Specificity Low Sensitivity Higher Kit Costs High Potential for interference
Immunoassay, ELISA, RIA,FIA Gold Standart Methods Roche, Siemens, Midray Abbott, Beckman Sciex, Agilent, Thermo Shimadzu, Waters.. Currrent Clinical Diagnostic Market Clinical Diagnosis with LC-MS/MS and HPLC
OUR VISION – Each LC-MS/MS will need an automated sample prep LC Zivak Multitasker Full Automated Sample Preparation and Injection System
1,5 min analysis time for HbA1c and HbF 6,0 min analysis time for A1c, F, A0, A2, S, C, D, E Variants Real walk-away system with unique modules HB-100 New Design – 2017
World’s only Walk-Away 25-OH Vitamin D2-D3 UHPLC-UV System – April-2016
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Psychoactive Drugs Urine LC-MS/MS Analysis Kit 7 min Amino Acid Biological Fluids LC-MS/MS Analysis Kit 20 min PKU Serum LC-MS/MS Analysis Kit 2 min PKU Dried Blood Spots LC-MS/MS Analysis Kit 2 min Organic Acid Urine LC-MS/MS Analysis Kit 20 min Neonatal Screening Dried Blood Spots LC-MS/MS Analysis Kit 1.5 min Immunosuppressant Whole Blood LC-MS/MS Analysis Kit 2 min VMA HVA 5-HIAA Urine LC-MS/MS Analysis Kit 15 min Catecholamines Urine LC-MS/MS Analysis Kit 16 min Metanephrine Urine LC-MS/MS Analysis Kit 13 min Neurotransmitters in Urine LC-MS/MS Analysis Kit 13 min 25-Hydroxyvitamin D2-D3 Serum LC-MS/MS APCIAnalysis Kit 2 min Total Homocysteine Serum LC-MS/-MS Analysis Kit 2.5 min Hemoglobin A1c Whole Blood HPLC Analysis Kit 1.5 min Hemoglobin Variant Whole Blood HPLC Analysis Kit 6.5 min PKU Serum HPLC Analysis Kit 2 min PKU Dried Blood Spots HPLC Analysis Kit 2 min 25-Hydroxyvitamin D2-D3 Serum HPLC Analysis Kit 6 min Vitamin A-E Serum HPLC Analysis Kit 8 min 25-Hydroxyvitamin D2-D3 Serum VD-200 UHPLC Analysis Kit 3 min
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