Working together for a world free of chemical weapons
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Working together for a world free of chemical weapons www.opcw.org Working together for a world free of chemical weapons At At SA SAB-22 22, The Direct ctor-Genera General request quested ed the Scie ientific tific Ad Adviso visory
Working together for a world free of chemical weapons
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Working together for a world free of chemical weapons
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to Schedule 1, 2 and 3 under the Chemical Weapons Convention should be considered in relation to the Convention, taking into account the SAB’s previous advice on CAS registry numbers (RC-2/DG.1, dated 28 February 2008, in paragraph 3.5 of the Annex).
subject to isotopic labelling, in a manner that would affect its relevance to the schedules of chemicals under the Chemical Weapons Convention; and
to Schedule 1, 2 and 3 under the Chemical Weapons Convention – in light of the SAB’s previous advice on CAS registry numbers (RC-2/DG.1, dated 28 February 2008, in paragraph 3.5 of the Annex); At At SA SAB-22 22, The Direct ctor-Genera General request quested ed the Scie ientific tific Ad Adviso visory Board Board (SA SAB) B) to to:
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to Schedule 1, 2 and 3 under the Chemical Weapons Convention should be considered in relation to the Convention, taking into account the SAB’s previous advice on CAS registry numbers (RC-2/DG.1, dated 28 February 2008, in paragraph 3.5 of the Annex).
subject to isotopic labelling, in a manner that would affect its relevance to the schedules of chemicals under the Chemical Weapons Convention; and
to Schedule 1, 2 and 3 under the Chemical Weapons Convention – in light of the SAB’s previous advice on CAS registry numbers (RC-2/DG.1, dated 28 February 2008, in paragraph 3.5 of the Annex); At At SA SAB-22 22, The Direct ctor-Genera General request quested ed the Scie ientific tific Ad Adviso visory Board Board (SA SAB) B) to to:
Working together for a world free of chemical weapons
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Working together for a world free of chemical weapons
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Working together for a world free of chemical weapons
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Working together for a world free of chemical weapons
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1993 CWC Opened For Signature
Grows by ~15,000/day
> 155,000,000 CAS Numbers Assigned since 1993 (Schedules created)
Working together for a world free of chemical weapons
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Working together for a world free of chemical weapons
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1A(1), ), 1A(2), ), 1A(3) > 1.3 Million
Poss ssibil ilities ities! 2B(4) 4) Limited ed only ly by imaginat ination! ion! Only y 17 chemi micals cals in Schedu dule le 3 Or are there? e?
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1A(1), ), 1A(2), ), 1A(3) > 1.3 Million
Poss ssibil ilities ities! 2B(4) 4) Limited ed only ly by imaginat ination! ion! Only y 17 chemi micals cals in Schedu dule le 3 Or are there? e?
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1993 CWC Opened For Signature
Grows by ~15,000/day
Working together for a world free of chemical weapons
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1993 CWC Opened For Signature
Grows by ~15,000/day
55 in Annex x
emicals (3 are not
Schedu dule led) d)
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Working together for a world free of chemical weapons
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Working together for a world free of chemical weapons
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Working together for a world free of chemical weapons
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Working together for a world free of chemical weapons
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= Atomic Number = Number of Protons Protons = Electrons (neutral atom)
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= Atomic Number = Number of Protons Protons = Electrons (neutral atom)
“H” “D” “T”
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Numbe ber of Neutr trons
Numbe ber of Pro rotons ns
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Numbe ber of Neutr trons
Numbe ber of Pro rotons ns
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Chemi mical bo bonding ing is al all ab about ut electro trons! s!
(isot
s do not
tron
s : c chemis istr try y of isot
me eleme ment is fo for practic ical purp rposes the same me)
= H-C-H (a “C” with 4 “bonds”, H’s are not shown)
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No Assigned CAS Registry Number
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No isot
es indicated ed
for prac actical ical purposes, , we we assume ume a sam ample le indica cated by this is struct cture contains ins all isotopes pes of each ch eleme ement nt in their eir nat atur ural l abundan bundance ce
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Schedule 1A(1) or 2B(4) If CD3 is considered “not Me”, this is unscheduled
= C-H CH3= “Me” =
D7 i-Pr
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Working together for a world free of chemical weapons
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Working together for a world free of chemical weapons
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(R)-3-Qu Quinucl uclidinyl yl benzilat ate CA CAS Number mber 62869-69 69-6 (S)-3-Qu Quinuc uclidi dinyl yl benzi zilat ate CA CAS Number mber 62869-68 68-5
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Not
antiomers Not
antiomers
C( C(S)P( )P(R) LD LD50
50 > 2000 mg/kg
C( C(R)P )P(S) LD LD50
50 99
99 mg/kg Enantiom antiomer ers C( C(R)P )P(R) LD LD50
50 > 5000 mg/kg
C( C(S)P( )P(S) LD LD50
50 38
38 mg/kg Enantiom antiomer ers Diastereome ereomers Differ eren ent t Proper perti ties! es!
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Soman (
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C( C(R)P )P(R) LD LD50
50 > 5000 mg/kg
C( C(S)P( )P(R) LD LD50
50 > 2000 mg/kg
C( C(R)P )P(S) LD LD50
50 99
99 mg/kg C( C(S)P( )P(S) LD LD50
50 38
38 mg/kg
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C( C(R)P )P(R) LD LD50
50 > 5000 mg/k
/kg C( C(S)P( )P(R) LD LD50
50 >
> 2000 2000 mg/k /kg C( C(R)P )P(S) LD LD50
50 99 mg/k
/kg C( C(S)P( )P(S) LD LD50
50 38 mg/k
/kg
H2O H2O
Enantiom antiomer ers
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Presence sence of one e might t indicat cate presen sence ce of the ot
Samp mplin ing g and analys lysis is is possi sible le with appropri
ate e met ethods
pment
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Sulfur lfur Mus ustard tard Replace “H” with “D” on Carbon 2 R or S?
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“HT”
This CA CAS numb mber er is not
Schedu dules les
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CWC Article cle VI, VI, paragr grap aph 2
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Parts ts VI, I, VII VII and nd VIII VIII to to the he Convention’s Anne Annex on
Impl plementation ementation and nd Verif ifica cation tion set set out the relevant vant requ quirem ement ents
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One iss issue ue th that th the SAB AB noted ed in in th the con context xt of
its pr previou ious recomm commenda ndati tion
salts is is th the role
he Che hemical mical Abst Abstracts cts Ser Service ice (CAS) AS) Regis egistr try Numb umber ers indica indicated ed in in th the sc sched edul ules es of
The SAB AB has has come come to to th the vie view th that, at, while while the the CAS AS Reg egistr istry Number mbers ar are a usef useful aid aid to to ide identifica tificatio tion, th they were ere int intended ended as as spec pecif ific ic id identifi entifier ers of
sche hedul uled ed ch chem emicals
There ap appear pears to to be be a questio uestion am among Stat tates es Partie ties ab abou
hether er the hese se nu numbe bers rs ha have a reg regulat lator
alue
The SAB AB wo would uld lik ike to to cau aution tion again against st suc such a view, bec ecau ause se th there ere is is no not nec eces essar sarily ily a one-to to-on
relationship ip be betw twee een CAS CAS Registr egistry Num Number bers an and che hemical ical structures
While th these ese num umber bers ar are us usef eful ul in in the the ide identifica tificatio tion of
emical com
pounds, this this us usef efuln ulnes ess sh shou
ld not lea lead to to th the assum ssumpt ptio ion that hat th they shou hould ld ha have any reg egulat latory po power er with ithin in the the con
xt of
th the Convention
At the he same same ti time, me, it it coul could be be hel elpf pful ul if if th the OPC PCW Declara Declaration tion Handboo dbook were re to to pr provide vide ref refere erence ces to to th the var arious ious CAS AS number numbers th that at ar are relat related ed to to an an entr entry in in th the sche hedul ules es (f (for
ample, for
differe erent isomer isomers of
sche hedu duled led chemi emica cal and nd for mixt xtur ures cont ntainin ining a sche hedu dule led chemi mica cal) l).
RC RC-2/DG DG.1, dated 28 28 Fe February 2008 2008, in in paragraph 3.5 of
Declaration ations Handbook
ferences s and e examples as s suggested
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https://www.opcw.org/our-work/non-proliferation/declarations-adviser/handbook-on-chemicals/
Working together for a world free of chemical weapons
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Working together for a world free of chemical weapons
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SAB Workshop #1: Chemical Forensics 20 – 22 June 2016, Helsinki, Finland (report forthcoming)
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https://www.opcw.org/special-sections/science-technology/science-technology-resources/ Science for Diplomats Chemical Weapons Convention S&T Monitor Science & Technology Resources Social Media Resources for Students and Teachers Fact Sheets Scientific Advisory Board The Hague Ethical Guidelines OPCW Today Capacity Building Programmes Director-General Speeches
Working together for a world free of chemical weapons
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https://www.opcw.org/special-sections/science-technology/science-technology-resources/ Science for Diplomats Chemical Weapons Convention S&T Monitor Science & Technology Resources Social Media Resources for Students and Teachers Fact Sheets Scientific Advisory Board The Hague Ethical Guidelines OPCW Today Capacity Building Programmes Director-General Speeches
Working together for a world free of chemical weapons
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Working together for a world free of chemical weapons
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Working together for a world free of chemical weapons
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SciTech@OPCW.org (email) @OPCW_ST (Twitter) www.opcw.org/special-sections/science-technology/