Wer kann uns helfen nicht krank zu werden? Auf dem Weg zum - - PowerPoint PPT Presentation

Wer kann uns helfen nicht krank zu werden? Auf dem Weg zum künstlichen Knochen

• U. Wolfram

Institute for Surgical Technology and Biomechanics, University of Bern, Switzerland

May 15, 2015

Global Issues

> ... > climate change > water > environment > disarmament > disease > age

http://www.un.org/en/globalissues/

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Global Issues

> ... > climate change > water > environment > disarmament > disease > age

http://www.un.org/en/globalissues/

2

Global Issues

> ... > climate change > water > environment > disarmament > disease > age

http://www.un.org/en/globalissues/

2

Global Issues

> ... > climate change > water > environment > disarmament > disease > age

http://www.un.org/en/globalissues/

2

Global Issues

> ... > climate change > water > environment > disarmament > disease > age

http://www.un.org/en/globalissues/

2

Global Issues

> ... > climate change > water > environment > disarmament > disease > age

http://www.un.org/en/globalissues/

2

Global Issues

> ... > climate change > water > environment > disarmament > disease > age

http://www.un.org/en/globalissues/

2

Life Expectancy

Male life expectancy (The UNDP Human Development Report 2009) Female life expectancy (The UNDP Human Development Report 2009)

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Life Expectancy

Further Life Expectancy German Population 2014

https://www.destatis.de/bevoelkerungspyramide/

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Population Pyramids

http://populationpyramid.net/

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Osteoporosis

20 40 60 80 100 Menopause Age in Years 1500 1000 500

Bone Mass Over Lifetime

Bone Mass in g Calzium

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Daily Clinical Cases

Images partially adapted from en.wikipedia.org September 17th, 2014.

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Bone as Hierarchical Material

mineral platelets ~ (50 x 25 x 2) nm collagen molecules ~ (300 x 1.5) nm 3-7 μm 50-200 nm non-collageneous proteins Single Lamellae Mineralised Collagen Fibre Mineralised Collagen Fibril Extra-Fibrillar Matrix ~200 μm Haversian channel Organ Level Lamellar Structure Microcracks upper tissue organisation levels lower tissue organisation levels Adapted from Reisinger, A. ILSB Vienna

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Approach

Ŝ11 Ŝ22 Ŝ33 f(S,ρ,M) E Ep Dc Dt

ϵp

ϵ0 ϵp

(1 - Dt)ϵ0 (1 - Dc)ϵ0 σt σc σc* σt* k = σt + σc X ϵ0

Images partially adapted from en.wikipedia.org September 17th, 2014.

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Identify Mechanical Behaviour

T ension Compression Conewise Hardening Conewise Damagable Spring

E Eωp Dωc Dωt

P2 g1 g2 E11 E22 E33 g3 ttt ctt cct tct tcc ccc ttc P2 g1 g2 E11 E22 E33 g3 ttt ctt cct tct tcc ccc ttc

asymmetric, anisotropic damageable stiffness tensor multiple yield surfaces control damaged plasticity Asymmetric Strength Analysis

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Whole Bone Simulation

Courtesy of Dr. Ghislain Maquer.

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Whole Bone Simulation

Courtesy of Dr. Hadi Hosseini.

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Where To Go?

mineral platelets ~ (50 x 25 x 2) nm collagen molecules ~ (300 x 1.5) nm 3-7 μm ~200 μm 50-200 nm non-collageneous proteins Haversian channel Organ Level Lamellar Structure Single Lamellae Mineralised Collagen Fibre Mineralised Collagen Fibril Extra-Fibrillar Matrix Current state of knowledge damaged elasto-plasticity Elasto-plastic and damage mechanisms unknown Microcracks upper tissue organisation levels lower tissue organisation levels Adapted from Reisinger, A. ILSB Vienna

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Where To Go?

In Silico Design of Hierarchical Materials Production Processes Based on In Silico Design In Silico Optimisation of Treatment Strategies and Clinics Related Experiments

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For what? To dance!

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Thank you for your attention!

Nize Nicolai Schäfer „Edinburghpano09“ - selfmade. Licensed under CC BY-SA 3.0 via Wikimedia Commons

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