Victor Babes Victor Babes National Institute National Institute - PowerPoint PPT Presentation

Team 3 Team 3 TRANSLATIONAL MEDICAL RESEARCH IN CANCER TRANSLATIONAL MEDICAL RESEARCH IN CANCER “Victor Babes Victor Babes” ” National Institute National Institute’ ’s s “ DIAGNOSIS CENTER DIAGNOSIS CENTER Translation of high-level tests and technologies in medical practice Improving survival and life quality for cancer patients

Research results translated to the Research results translated to the Diagnosis Center Diagnosis Center New immunohistochemical immunohistochemical algorithms algorithms for cancer diagnosis; for cancer diagnosis; New In situ hybridization for Epstein Barr virus in undifferentiated In situ hybridization for Epstein Barr virus in undifferentiated carcinoma of nasopharynx nasopharynx and Hodgkin lymphoma; and Hodgkin lymphoma; carcinoma of (CISH) in situ in situ hybridization for Her Chromogen hromogen (CISH) hybridization for Her- -2/neu gene 2/neu gene C amplification in breast and gastric carcinoma; amplification in breast and gastric carcinoma; ) in situ in situ hybridization for Fluorescent Fluorescent ( (FISH FISH) hybridization for bcl bcl 2 translocation in 2 translocation in follicular malignant lymphoma; malignant lymphoma; follicular FISH for gene fusion in Ewing sarcoma; FISH for gene fusion in Ewing sarcoma; Molecular detection of K- -ras ras gene mutation in colon carcinoma; gene mutation in colon carcinoma; Molecular detection of K FISH for FISH for ALK gene mutation ALK gene mutation in in anaplastic anaplastic malignant lymphoma malignant lymphoma and in bronchopulmonary bronchopulmonary adenocarcinoma adenocarcinoma (in preparation) (in preparation); ; and in c- -kit gene mutation detection in kit gene mutation detection in GISTs GISTs (in preparation) (in preparation); ; c EGFR gene mutation in in lung lung adenocarcinoma adenocarcinoma (in preparation). (in preparation). EGFR gene mutation

Number of tests (2007-2012) 100800 2012 97200 2011 98100 2010 85500 2009 79191 2008 68850 2007 0 20000 40000 60000 80000 100000 120000

Number of investigated patients 11200 10800 2012 10900 2011 2010 9500 2009 2008 8799 2007 7650 0 2000 4000 6000 8000 10000 12000

HISTOPATHOLOGY HISTOPATHOLOGY IMMUNOHISTOCHEMISTRY IMMUNOHISTOCHEMISTRY MOLECULAR DIAGNOSIS MOLECULAR DIAGNOSIS Ultrastructural Ultrastructural DIAGNOSIS Medical genetics Medical genetics pathology pathology CENTER y y Immunology Immunology g g o o 25 CONTRACTS l l o o i i b b o o for medical services i i d d a a R R

Numbers of Contracts (2007-2013) 25 25 25 22 19 20 15 15 15 10 5 0 2007 2008 2009 2010 2011 2012 • Medical institutes and clinical hospitals at national level • Ambulatories and surgeries