Victor Babes Victor Babes National Institute National Institute - - PowerPoint PPT Presentation

Team 3 Team 3 TRANSLATIONAL MEDICAL RESEARCH IN CANCER TRANSLATIONAL MEDICAL RESEARCH IN CANCER

“ “Victor Babes Victor Babes” ” National Institute National Institute’ ’s s DIAGNOSIS CENTER DIAGNOSIS CENTER

Translation of high-level tests and technologies in medical practice Improving survival and life quality for cancer patients

Research results translated to the Research results translated to the Diagnosis Center Diagnosis Center

New New immunohistochemical immunohistochemical algorithms algorithms for cancer diagnosis; for cancer diagnosis; In situ In situ hybridization for Epstein Barr virus in undifferentiated hybridization for Epstein Barr virus in undifferentiated carcinoma of carcinoma of nasopharynx nasopharynx and Hodgkin lymphoma; and Hodgkin lymphoma; C Chromogen hromogen (CISH) (CISH) in situ in situ hybridization for Her hybridization for Her-

• 2/neu gene

2/neu gene amplification in breast and gastric carcinoma; amplification in breast and gastric carcinoma; Fluorescent Fluorescent ( (FISH FISH) ) in situ in situ hybridization for hybridization for bcl bcl 2 translocation in 2 translocation in follicular follicular malignant lymphoma; malignant lymphoma; FISH for gene fusion in Ewing sarcoma; FISH for gene fusion in Ewing sarcoma; Molecular detection of K Molecular detection of K-

• ras

ras gene mutation in colon carcinoma; gene mutation in colon carcinoma; FISH for FISH for ALK gene mutation ALK gene mutation in in anaplastic anaplastic malignant lymphoma malignant lymphoma and in and in bronchopulmonary bronchopulmonary adenocarcinoma adenocarcinoma (in preparation) (in preparation); ; c c-

• kit gene mutation detection in

kit gene mutation detection in GISTs GISTs (in preparation) (in preparation); ; EGFR gene mutation EGFR gene mutation in in lung lung adenocarcinoma adenocarcinoma (in preparation). (in preparation).

68850 79191 85500 98100 97200 100800

20000 40000 60000 80000 100000 120000 2007 2008 2009 2010 2011 2012

Number of tests (2007-2012)

7650 8799 9500 10900 10800 11200

2000 4000 6000 8000 10000 12000

Number of investigated patients

2012 2011 2010 2009 2008 2007

25 CONTRACTS for medical services

DIAGNOSIS CENTER Ultrastructural Ultrastructural pathology pathology

HISTOPATHOLOGY HISTOPATHOLOGY IMMUNOHISTOCHEMISTRY IMMUNOHISTOCHEMISTRY MOLECULAR DIAGNOSIS MOLECULAR DIAGNOSIS

Medical genetics Medical genetics Immunology Immunology R a d i

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i

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• g

y R a d i

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y

• Medical institutes and clinical hospitals at national level
• Ambulatories and surgeries

15 15 19 22 25 25

5 10 15 20 25 2007 2008 2009 2010 2011 2012

Numbers of Contracts (2007-2013)