Understanding the causes of disease & Covid 19 connecting - PowerPoint PPT Presentation

Understanding the causes of disease & Covid 19 – connecting molecular science with health records • Chairs: • John Danesh, University of Cambridge • Adam Butterworth, University of Cambridge • Panellists: • Ewan Harrison, University of Cambridge • Mark Caulfield, Queen Mary University of London • Aroon Hingorani, UCL • Emily Jefferson, University of Dundee This session will start at 11:45 BST. Please use the Q&A function to ask questions to speakers. You are welcome to comment using the chat function, but we cannot guarantee this will be monitored.

Understanding Causes of Diseases: Linking molecular science to e-Health Records at scale • Multi-omics Cohorts Consortium • Microbial carriage Multi-omics cohorts Integrative analyses • Building Empowering Polygenic Score Catalog tools & genomic • Addressing ethnic • ‘Gut Reaction’ Health resources medicine bias in genomic medicine Data Research Hub • Genomic medicine for rare diseases

https://www.cogconsortium.uk Tracking SARS-CoV-2 in the UK Ewan Harrison 25/06/2020

COVID-19 GENOMICS UK (COG-UK) consortium 15 regional sites: 1. Belfast 2. Birmingham 3. Cardiff (PHW) 4. Cambridge 5. Edinburgh 6. Exeter Central sequencing site 7. Glasgow and COG-UK Hub 8. Liverpool 9. Newcastle 10. Nottingham 11. Oxford 12. Portsmouth 13. London (UCL) 14. London (PHE – Colindale) COG-UK Administration 15. Sheffield £20M

Operational structure Electronic health records UK Public Health Agencies Laboratories COG-UK Sequencing hub COG-UK Analysis teams UK Public Health Agencies Laboratories Regional sequencing sites

Sequencing Sequencing technology agnostic https://www.ncbi.nlm.nih.gov/books/NBK554776/figure/article-52171.image.f5/ Open access data

COG-UK - Analytical focus • Introductions and spread • Nosocomial transmission • Tracking variation – diagnostics primer binding sites • Treatments and vaccines – following the emergence of drug resistance and variation in vaccine antigens • Transmission tracking – effects of interventions, outbreaks, contact tracing • Evolutionary analysis • Tracking emergence of viral variants

Ongoing analysis • Determined numbers of introductions and likely source • Emergence of three dominant lineages UK5, UK16 and UK17. • Estimation of R in London • Hospital and care home transmissions • Screening of diagnostic primers Andrew Rambaut • Effect of D614G spike proteins Oliver Pybus mutation Nick Loman Tom Connor Richard Myers David Aanensen Erik Volz

Future s nt International r , Analysis and knowledge exchange Local reporting feeding back to NHS Host Genomics and clinical data linkage National infrastructure Second COVID-19 wave Future pandemics – flu