Trends nds i in Personaliz nalized ed Medicine icine Scot - - PowerPoint PPT Presentation

trends nds i in personaliz nalized ed medicine icine
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Trends nds i in Personaliz nalized ed Medicine icine Scot - - PowerPoint PPT Presentation

Trends nds i in Personaliz nalized ed Medicine icine Scot cott Jenki Jenkins, Ph. h. D. Vice e President ident Dell l Healt lthcar hcare e & Life Sciences nces Time M me Magazine ine Januar January 18, 18, 2010 2010


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Trends nds i in Personaliz nalized ed Medicine icine

Scot cott Jenki Jenkins, Ph.

  • h. D.

Vice e President ident Dell l Healt lthcar hcare e & Life Sciences nces

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Time M me Magazine ine – Januar January 18, 18, 2010 2010

DELL CONFIDENTIAL

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Independent (600K)

Sell to

US US Healthca Healthcare System e System -

10,000+ hospitals, 750,000+ physicians – Employed (150K) Independent(300 Affiliated, 300 Unaffiliated)

Hospita l 1 Hospita l 2 Hospita l 5 Hospita l 4 Hospita l 3

Affiliated (300K)

Hospital Hospital, then Doc

Employed (150k)

Doc

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Private Exchanges – Single Stakeholder

4

Confidential

Primary goals of a private HIE: physic physicia ian attract attractio ion n and ARRA ARRA readin readines ess

Governance a Governance and nd Project Management Office Project Management Office Design, D Design, Deployment, eployment, Hosting and Helpdesk Hosting and Helpdesk Support Support

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Metcalf’ calf’s L Law

DELL CONFIDENTIAL

Metcalfe's law characterizes many of the network effects of communication

technologies and networks such as the

Internet, social networking, and the World Wide Web. It is related to the fact that the number

  • f unique connections in a network of a

number of nodes (n) can be expressed mathematically as the triangular number

n(n − 1)/2, which is proportional to n2

asymptotically.

1 10 66

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DELL CONFIDENTIAL

SINGLE LE M Molecule cule

10 yrs 15 yrs 5 yrs

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Single M ngle Molecul cule

1 Tb - 30 Mins, HG = $20k 2yrs: 10 Tb - 30 Mins, HG =$1k

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DELL CONFIDENTIAL

Patient ient C Centric L c LifeC eCar are

Patient scenario in the future

  • Improve

quality of life

  • Increase life

span

Source: Science, Vol. 207, 17 March 2000

Genotype recorded Secure database

+

Personalized immunization Screening schedule Preventive measures

+

Life Screening based on biomolecular profiling Refined treatment Drugs Developed to target particular disease subtypes on particular genetic background

Baby Hospital Adult

Physician’s office

BioBank

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DELL CONFIDENTIAL

Today ay’s m medicine c icine challenge: llenge: One si ne size doesn’ e doesn’t f fit al all

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SLIDE 10

DELL CONFIDENTIAL

GCCCACCTC GCCCGCCTC

Diagnostics/Biomarkers Drug Metabolism

Governments and academic medical centers building ‘biobank’ repositories of samples and information.

Lar Large ge pat patien ent net netw orks w w ill enabl enable target eted t ed treat atment nts

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What hat is s at at st stake? ake? Top

  • p Globa
  • bal 15

15 Produ

  • ducts

11 Data from IMS HEALTH: http://www.imshealth.com/deployedfiles/imshealth/Global/Content/StaticFile/Top_Line_Data/Global_Top_15_Products.pdf

Note: Lipitor loses patent exclusivity in 2011 – Generic Drugs will be available

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DELL CONFIDENTIAL

Answer: The HIPAA Privacy Rule recognizes that a deceased individual’s protected health information may be relevant to a family member’s health care. The Rule provides two ways for a surviving family member to obtain the protected health information of a deceased relative. First, disclosures of protected health information for treatment purposes—even the treatment of another individual—do not require an authorization; thus, a covered entity may disclose a decedent’s protected health information, w ithout authorization, to the health care provider w ho is treating the surviving relative. How can family members of a deceased individual obtain the deceased individual's protected health information that is relevant to their ow n health care? Second

  • nd,

, a covered ed entity mu must treat a deceas ased ed indiv ividual’ idual’s legall gally author horiz ized ed execut utor

  • r or adminis

nistrator

  • r,

, or a person

  • n w ho is other

erw is ise e legally aut authorized to

  • act

act on

  • n the

he behal behalf of

  • f the

he decea deceased indi ndividual or

  • r

his estate, e, as a personal

  • nal repres

esent entativ ive e w ith h respect ect to protect ected ed healt lth h infor

  • rma

mation ion relevant ant to such ch repres esent entation. ion. Theref efor

  • re,

e, if it is w ithin in the scope e of such ch personal

  • nal repres

esent entativ ive’ e’s aut authority unde under ot

  • ther

her law, the he Rul ule e per permits the he per personal repr presentative to obtain ain the informa mation ion or provide de the appropr

  • pria

iate e author

  • riz

ization ion for its disclos losur ure. e.

HIPAA & & Unint nten ended C ded Consequences equences

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DELL CONFIDENTIAL

Previv ivor

  • r - Cancer Free at 33, but

Weighing a Mastectomy

Source: NY Time, Sep 16, 2007

Personalized Medicine - Biomarkers

  • Family History of Cancer Breast/Ovarian/Colon
  • Mother recovering from Chemotherapy
  • Asymptomatic for pre-cancerous cells
  • Positive for BRAC-1

Diagnostic Monitoring

  • Mammography
  • Breast MRI
  • Breast Ultrasound
  • Ovarian Ultrasound w/CA-128 Blood Test

Preventative Measures

  • Prophylactic oophoectomy
  • Prophylactic Mastecomy
  • Tamoxifen

Search NYTimes Archive 2007 = “previvor” http://www.nytimes.com/2007/09/16/health/16gene.html?_r=1

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Getting t ing the R Right ht S Statin in

DELL CONFIDENTIAL

Dia iagnos nosed: d: High h Choles lester erol

  • l

He e tried ed Les Lescol col tw ice, b but ut it di didn dn’t agree w e w ith h h him.

Novartis CEO Daniel Vasella

Health Blog WSJ's blog on health and the business of health

JANUARY 3, 2008, 9:23 AM ET

“I don’t have them on Lipitor, so I take Lipitor. It’s funny but it’s true.” “I have side effects on our ow n lipid-lowering drug,” he told the Health Blog

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DELL CONFIDENTIAL

Fer Fertility y and and Genet enetic Test ests

Basic Medicine

  • 40 Yr Female
  • Healthy
  • No family history of fertility problems
  • Several Miscarriages
  • Full workup (Slightly High FSH)
  • Specialties have no definitive answers
  • 3 IVF end in Miscarriage

Personalized Medicine in Action

  • New Blood test for Key genetic markers

(was included as an after thought)

  • Tested Positive for PAI - 1

(Plasminogen activator inhibitor-1)

  • Lovenox (Blood thinner) used to

counteract natural mechanism

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What hat Happen appened?

DELL CONFIDENTIAL

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Thank You hank You