Treat Your Building as a Patient: Environmental Reduction of Bacteria Through Continuous Visible Light Disinfection
What is Indigo ‐ Clean TM ? • An overhead light fixture which continuously and safely disinfects the environment using visible light Mixed ‐ White Indigo ‐ Only Indigo Disinfection Mode = White Disinfection Mode = Increased Disinfection Only Ambient White Light + Disinfection 2
What is Visible Light Disinfection?
Indigo ‐ Clean Safety Summary
How Does Indigo ‐ Clean Work? 1. Continuous, automatic, safe system creates hostile 2. Environment creates Reactive Oxygen Species environment for bacteria within bacteria causing inactivation = 3. Pathogen inactivation breaks the 4. Measured bacterial reduction* environmental chain of infection 5 *Maclean M., et. al. Environmental decontamination of a hospital isolation room using high ‐ intensity narrow ‐ spectrum light, J. Hosp. Infection Vol. 76, pp. 247 ‐ 251 (2010)
Potential Healthcare Applications OR Sterile Oncology Processing Patient Rooms Bone Waiting Marrow Areas Transplant Wound Triage/ Care Trauma Clinics 6
Why Indigo ‐ Clean in the OR?
Indigo ‐ Clean In An Operating Room Airborne Pathogens Variety of Surfaces Hard to Reach 8
Types of Visible Light Disinfection Indigo ‐ Only Mixed White • Use of complimentary colors • Disinfection only allows for ambient lighting applications 9
Clinical Implementation of Indigo ‐ Clean TM • Overhead light fixtures which continuously and safely disinfect the environment using visible light Wall switch can be used to select desired mode OR Occupancy/ Vacancy control can automatically switch Mixed White Indigo ‐ Only between modes White Disinfection Mode = Indigo Disinfection Mode = 10 Ambient White Light + Disinfection Increased Disinfection Only
Indigo ‐ Clean Operating Room Solutions 2’x4’ ‐ M4SEDIC24 2’x2’ ‐ M4SEDIC22 1’x4’ ‐ M4SEDIC14 11
Indigo ‐ Clean Application: Operating Rooms • Apply standard IES lighting guidelines to determine number of fixtures per room and layout: 1:1 Replacement ~625 sq. ft. ~625 sq. ft. ~625 sq. ft. 12
Demonstrated Laboratory Susceptibility to Visible Light Disinfection Gram-Positive Bacteria • Clostridium perfringens • Staphylococcus epidermidis (CONS) • Staphylococcus hyicus (CONS) ESKAPE Pathogens • Streptococcus pyogenes • Enterococcus faecalis • Listeria monocytogenes • Mycobacterium terrae • Staphylococcal Aureus* • Corynebacterium striatum (including MRSA) 1 Gram-Negative Bacteria • Klebsiella pneumoniae • Proteus vulgaris • Escherichia coli (E. coli) • Acinetobacter baumannii • Campylobacter jejuni • Pseudomonas aeruginosa • Salmonella enteritidis • Shigella sonnei • Enterobacter species • Serratia spp Yeast & Filamentous Fungi • Aspergillus niger • Candida albicans • Saccharomyces cerevisiae *= Demonstrated clinical susceptibility Bacterial Endospores to presumptive S. Aureus & MRSA • Clostridium difficile • Bacillus cereus 1 Maclean M., et. al. Environmental decontamination of a hospital isolation room using high ‐ intensity narrow ‐ spectrum light, J. Hosp. Infection Vol. 76, pp. 247 ‐ 251 (2010)
Glasgow Royal Infirmary: Intensive Care Unit (Initial Studies) 2 Whole Room Results Surface-Specific Results Lights Off Lights On 76% reduction 86% reduction Significant reduction of total bacterial contamination Bacterial reduction on a range of surfaces before on surfaces around the room (2-day use) and after use of the Visible Light Disinfection All reductions in bacterial contamination were achieved over and above standard cleaning and infection control practices 2 Maclean M., et. al. Continuous decontamination of an intensive care isolation room during patient occupancy using 405nm light technology. Journal of Infection Prevention, 14(5); 176 ‐ 181 (2013)
Froedtert & The Medical College of Wisconsin Froedtert Hospital • GI Diagnostic Waiting Area • Easier to show a reduction due to high amount of bacteria • Proximity to procedure rooms • Approximately 450 ft. 2 (Equivalent to small OR) • Results consistent with previously published patient room results • Additional studies underway
Clinical Results for Indigo ‐ Clean TM • Inactivation of S. aureus in Waiting Room “In Phase 2 of the trial, where the lighting deployment was optimized across the room, we were able to 70%+ Decrease improve the bacterial reduction to more than 70%.” ‐ Dr. Nathan Ledeboer, Associate Professor of Pathology, Medical College of Wisconsin 16
Clinical and Commercial Success! • State ‐ of ‐ the ‐ art facilities in Las Vegas and other unannounced locations “Even the lights will get • Henderson Hospital ‐ into the safety prevention Universal Health with special indigo lighting Services Inc. built into the ceilings that will kill bacteria” 17
Thank Thank You!!! ou!!! For more information, visit www.indigo ‐ clean.com or www.kenall.com 18
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